Transcript Motic Digital Pathology Solution 数字病理与远程会诊系统

MOTIC VM600 Virtual Microscope
Development of Motic’s New Model;
Features & Improvements, Model
Strategy, and Model Competition
Motic International Dealer Meeting
March 2009
Topics Covered
1. Motic VM Introduction: Hardware & Softwares
2. Application solutions:
a. Clinical Diagnosis/
b. Consultation, Research
c. Education
3. VM System Operation & software
4. Competitive Analysis
Motic Products Solution
www.moticpathology.com
VM600-4：Digital Slide Scanner
1、DPCC（ Digital Pathology Consultation &
Communication Platform ）
www.motic.com/dssweb
2、DSS（ Digital Slide Server System ）
VM：Digital Slide View software
Motic VM Components (Hardware & Scanning software))
4
Scanning Process Demo：
Scanning
Digital Slide View Demo
Motic Pro 285 CCD
1. Motic 285A：
2/3 " , 1360 x 1024, 6.45m x 6.45m
MCAM285 Technical Data
Item
Sensor Size
MCAM285
2/3"CCD
Resolution
1.4 mega pixels, 1360 X 1024 pixels
Pixel Size
6.45m x 6.45m
Frame Rate
15 fps / second
Shutter
Electronic
Dynamic Range
>44db S/N
Scanning System
Progressive
Minimum Illumination
USB Interface
Voltage
Operating Current
Power Consumption
≈3Lux
USB2.0(480Mbit/sec
DC 5V± 5%
≈260mA
≈1.3W
Operating Temperature
0℃-50℃
Storage Temperature
0℃-60℃
Relative Humidity
40%-80%
OS recommended
WINDOWS2000 / WINXP / VISTA
Scanning Speed
Objective: 20x；
Specimen：10mmx10mm；
Scanning Method: Standard；
Speed：About 4 min
VM600 Stage Configuration
•X - 272mm；Y - 196mm；Z - 93mm ;
•Travel range of 80mm by 24mm
•Stage Accuracy:
1.5625um for x/y –axis,;
0.015um for z-axis;
•Relocation Accuracy: <1um
Motic VM600 Recommended PC
Specifications
Workstation System:
•Windows XP Professional
•Intel Core(TM) 2 processors
•4GB RAM
•300GB disk storage
•22 “ Monitor(or larger Optional)
Motic VM Scanning Methodology
1. High Precision
Auto –Focus every Image , high quality
2. Standard ：
Build Scanning model , good quality with faster
scanning speeds
3. ROI（Region of Interest）:
Scan whole slide with low magnification(2x or 4x)
first, then scan ROI with higher magnification . Small
Digital slide Size(<10M), useful and convenient for
pathology or educational applications (Motic only
feature)
4.Multilayer Focus:
Multilayer focus and amalgamation each tiled
image . Very high quality ,especially for thick glass
slide (but may be too slow for most applications)
Multilayer Focus Scanning
Multi-Layer Amalgamation
Traditional Pathology Workflow
Surgery Center
Pathology Center
Living
specimen
Freezes
Tissue
Tissue
specimen
Pathology Education
Fix, Dehydrate,
Embedding….
Histoprocessing
Slide
Staining
Pathology Diagnosis
Pathologist Center
Slides
Digital Pathology Solution: Adjusting Standard
Workflows
Surgery Center
Pathology Center
Living
specimen
Freezes
Tissue
Tissue
specimen
Fix, Dehydrate,
Embedding….
Histoprocessing
Slide
Staining
Education
Image Analysis
Workflow Management
Pathology Diagnosis
&Analysis
Remote-Consultation
Digital
Slides
Pathologist Center
Slide
Future Digital Pathology Directions
•Information Workflow, including Digital Slides…
• Integrated Patient records (HIS/PACS…)
•Education & Clinical
•Remote-Consultation
•Image analysis
MOTIC’s Digital Development Makes the
VM600 The Next Logical Progression …
Microscope
Micro+Camera
Digital Pathology
VM Application Solutions
VM600 Digital Slide Applications
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Educational (Cell Morphology, Histology, Pathology, etc.)
Digital Slides Classroom Teaching
Remote Teaching and Learning
Virtual (Web) Teaching Lab for Images view and conference
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Clinical Diagnosis(Pathology)
Digital Images Data and workflow Management
Remote Consultation
Digital Slides Conference
Aided Diagnosis
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Research
Digital Slides Data
TMA
Image analysis
Pharmaceuticals
VM Educational Applications
Digital slides Education System for Pathology and
Histology Teaching
Classroom Teaching
1. Digital Slides reduce concerns about slide making,
loss, breakage or fading;
2. Archive and share critical slides;
3. Built-in Digital Slide information management to
reduce teacher prep time for course development and
dedicate more time to viewing
Digital slides Testing
1. Manage digital slides to create a test library as an
effective means for distributing testing materials;
2. Auto testing
Digital Slides gallery( Web view)
1. Anywhere , anytime access via internet on web, Prelearning and Review ;
2. Improving the teaching level and learning effectively;
Motic Digital Slides Server Software System(DSS)
Lan/Internet
IE View
DSS Server
Web-Based
IE View
Motic VM
workstation
Motic Digital Slides Server System(DSS)
Web-Based
View by
annotation ,
convenient for
teaching and
learning
Incorporating VM600 with Motic Net as
an effective teaching tool..
Education (VM600 with Motic Net)
For Pathology Diagnosis
(Secondary) & Consultation
Motic VM Feature:
Observe slide by Motic VM whiling or
after scanning the slide ,it is the best way
for beginning of diagnosing training
Digital Pathology Consultation & digital slide
Communication Platform
Remote Experts
DPCC Platform
LAN or Internet
（ADSL）
LAN or Internet
（ADSL）
Motic VM
Remote Consultation
Center
Consultation station
On business or at home
Motic DPCC Platform Web Address
http://www.moticpathology.com
Digital Pathology Information Workflow
Motic VM
Digital Slides
Remote Consultation
Conference
Internet)
Report
Competitive Analysis
Market Sector Competitors
1. Zeiss Mirax
2. Olympus Bliss HD or .slide
3. Aperio
4. Hamamatsu NDP
5. Nikon Coolscope
6. Claro
7. DMetrix
……
Zeiss
Mirax DESK(1-slide)
Mirax MIDI(12-slide)
Mirax SCAN(300-slide)
Objective: Plan-Apochromat 20x/0.8
Scan camera:
SONY DFW-X710 or others
(1/3“inch, 1024 x 768 pixels, cell size
4.65 x 4.65 µm )
Zeiss (3DHISTECH,Hungarian company)
MIRAX Viewer - the virtual microscope
MIRAX MFM - fluorescent slide viewer
MIRAX TMA - a powerful tool for high throughput tissue microarray evaluation
IH-Lab - software for fast evaluation of immunohistochemistry stained samples
HistoQuant - quantitative and qualitative analysis application
MIRAX E-School - teaching material authoring tool with exam module
MIRAX 3D - an application for 3-dimensional reconstruction of serial slides
E-Consult – teleconsultation software
MIRAX DB - database program for efficient data management
ToxicoPath-LIS - application for the management and administration of
toxicopathology research
Olympus
Dot slide(1-slide/50-slide)
Objectives : 2x PLAPON, 10x, 20x, 40x UPLSAPO, optional, e.g. 100x oil
Illumination: brightfield with 100 W halogen lamp house, optional: fluorescence, polarisation
Digital CCD camera: 2/3” CCD camera, 6.45 μm x 6.45 μm pixel size
Software functions and modules
.View images locally, zoom, crop and rotate images
.Net Image Server software for remote access to virtual slides with dotSlide software
.Conferencing module for simultaneous and synchronised viewing of virtual slides, conference
access control and user management, minute taking tool, chat function
.TMA module to acquire individual images of TMA cores
Bacus: Bacus Laboratories,inc., a whollyowned subsidiary of Olympus America .
Founded in 1994, is a leader and innovator
in the field of VM.
Hamamastu
NDP: 210-slide
Objective lens: 20X, NA 0.7
CCD:
TDI sensor,4096 x 64 pixel , Line scanning
Software: Developed by other company
Distributed now in the
USA through the
Olympus network,
approx cost $120K
Aperio
120-slide
1 -slide
5-slide
1-slide(Oil)
Objective lens:
PLAN-APO 20x / 0.75
CCD: Line 3-CCD, 1040 x
1 pixel
Nikon
CoolScope
CCD:2/3-inch.
(total number of pixels: 5.24-mega pixels;
effective 5.07-mega pixels)
Dmetrix
.Objective : Array Micro lens (80)
.The fastest scanning system
Claro(Japan)
Toco: 1-slide
VS0201AS1 : 20-slide
VS0801AS1: 80-slide
Objective: Carl Zeiss Aplan 20x, 40x
Camera: 1/2 CMOS (1280 x 1024) or 1/2 IT CCD' (1280 x 960)
Clarient/Trestle/Dako
Clarient: formed in 1996 to develop and market the ACIS(R) Automated
Cellular Imaging System, in cancer diagnostics
Sells Its ACIS Instrument Business to Carl Zeiss for $12.5
Million
Following the acquisition of Trestle and of Clarient's equipment business,
Carl Zeiss has become the leading provider of solutions for telepathology,
digital slides and computer- supported diagnostics with more than 500
installed systems.
In marketing a clinical version of the system, Carl Zeiss
MicroImaging said it is collaborating with the Danish diagnostics
company Dako, a manufacturer of reagents for tissue-based cancer
diagnosis.
Motic’s Strategic Positioning:
1. Natural Digital progression for Motic into Virtual slide making market
2. Offer “single-source” complete and easy integrated with VM hardware
and software
3.
4. Package Applications by combining VM Digital slide with Motic Net
5. Highest Resolution Sony CCD
6. Different scanning methods; ROI slide for remote consultation
7. Value-Alternative to customer
Motic: Value-Based alternative to easy and efficient
digital slide creation and integration!