Colorectal Cancer Awareness in TN: Risk Factors, Screening, Outreach

Keith D. Gray, M.D.

Assistant Professor of Surgery Division of Surgical Oncology The University of Tennessee Medical Center

CRC Facts

• 2008, 150K new cases and 50K deaths • Lifetime risk of developing colon cancer is 1 in 19 • 2 nd leading cause of cancer death among men and women combined • Death rate has been decreasing over last 20 years, due to earlier screening and better imaging and treatment

Uncontrollable Risk Factors for Developing Colorectal Cancer

• Age – 50 or older • Family history of cancer of the colon or rectum • Personal history of cancer of the colon, rectum, ovary, endometrium or breast • History of polyps of the colon • Inflammatory bowel disease – ulcerative colitis or Crohn’s disease • Hereditary conditions

Controllable Risk Factors for Developing Colorectal Cancer

• Obesity • Physical inactivity • Cigarette smoking • Diet high in red or processed meat • Heavy alcohol consumption • Inadequate screening

•50-75% of cancers can be prevented by lifestyle and dietary changes

CRC Burden in TN

TN = 52.3 (50.5, 54.2)

CRC Burden in TN

TN = 18.9 (17.8 -20)

Disparate CRC Outcomes

TN Risk Profile (2007)

• 13.5% (12.4%) below poverty – 15 th – Median per capita income = $13,282 in Central Appalachia, lowest in the nation • 24.1% (19.6%) < HS education – 7 th – 9.6% < 9 th grade education (5 th) • 31.5% sedentary – 2 nd • 67.4% obese (BMI>25) – 4 th – High fat diets, physical inactivity • 26.4% (16.3% - 32.5%) consume 5+ fruits/veges per day • 24.3% currently smoke (5 th )

TN Screening Report (2006)

•

FOBT (>50)

– Last 2yrs: 25.6% (12.1 – 26.6%) – Last 1yr: 15.7% (6.6 – 22.5%) •

Colonoscopy (>50)

– Ever: 56.2% (49.8 – 69.2%) – <10yrs: 53.4% (46.6 – 66.4%) – <5yrs: 49.9% (40.6 – 60.9%)

Establishment of CRC Screening Guidelines

• ACS established CRC early detection guidelines in 1980 – 1997 – 1 st update – 2000 – 2 nd update • 1995-2000 Medline data • Colorectal Cancer Advisory Committee – 2003 - technology update • Immunochemical FOBT (iFOBT) added as acceptable screening method – 2006 - ACS and US Multi-Society Task Force issued a joint guideline update for postpolypectomy and postcolorectal cancer resection surveillance • Follow-up intervals were often too short, increasing cost and potential patient risk – 2008 - Virtual Colonoscopy accepted as screening tool Eddy D. CA Cancer J Clin 1980;30:193-240 Smith RA, et al. CA Cancer J Clin 2001:51:38-75 Mysliwiec PA, et al. Ann Intern Med 2004;141:264-271 Ko CW, et al. Gastrointest Endosc 2007;65:648-56

CRC Screening Methods

• – – –

Fecal Occult Blood Test (FOBT

) 2 samples from each of 3 consecutive stool samples at home Avoid NSAIDS (7d), Vit C sources (3d), red meat (3d) – • • Stool sample from DRE is inadequate!

Low sensitivity (< 5%) as bleeding often intermittent and blood may not be present in entire stool Sole method of FOBT in up to 33% of PCP’s Nadel MR, et al. Ann Intern Med 2005;142:86 94 • • Advantages Cheap, private, no bowel prep Clinical trials show 33% reduction in CRC mortality with proper use; these results may not be realized in community settings because common use of in-office tests and inappropriate follow-up of positive results Nadel MR, et al. Ann Intern Med 2005;142:86-94 Smith RA, et al. CA Cancer J Clin 2001:51:38-75

Fecal Immunochemical Test (FIT)

• Mono/polyclonal antibody detect intact globin protein portion of human Hgb – Specific for globin in LGI tract since globin won’t survive passage through UGI tract • No cross-reactivity with non-human Hgb or foods • Smith A, et al (

Cancer

cancer and 43% for high risk adenomas in 2000+ patients – Similar findings by 2006) demonstrated sensitivity of 87% for

InSure

• ACS statement:

“in comparison with guaiac-based test for the detection of occult blood, immunochemical test are more patient-friendly, and are likely to be equal or better in sensitivity and specificity.”

• Less commonly used Levin B, et al. CA Cancer J Clin 2003;53:44-55 Smith A, et al. Cancer 2007;107:2152-2159

Endoscopy v. DCBE

• DCBE – Instilling of barium and air to define colonic mucosa – Less sensitive for subcentimeter lesions – Often used with near-obstructing lesions • Flexible Sigmoidoscopy – Veterans Affairs Cooperative Study Group; 3121 patients • Exam to splenic flexure detects majority of CRC’s but misses >50% of proximal colon cancers Lieberman DA, NEJM 2000;20-162-168 – No need for sedation – Best is combined with FOBT/FIT • Colonoscopy – Gold standard when cecum is reached – Risk of perforation – All Roads Lead to Colonoscopy!

ACS recommendations for CRC screening in average-risk, asymptomatic people

Test

FOBT or FIT* Stool DNA Test Flex Sig* FOBT + Flex Sig* DCBE* CT colonography Colonoscopy

Frequency ( starting at age 50)

Annually Interval uncertain Q 5 years Annual FOBT/FIT and Flex Sig q 5 years q 5 years q 5 years q 10 years

*

All positive test should be followed up with colonoscopy. DCBE +/- Flex sig is a suitable alternative.

Individuals at “increased risk” of developing CRC

• 2x average risk in this population; accounts for 15-20% of colon cancers • Who’s at increased risk?

– h/o of AP/CRC in any 1 st degree relative <60, or >2 1 st degree relatives with h/o AP/CRC of any age (w/o hereditary syndrome) • Colonoscopy at age 40 or 10 years before youngest case • Repeat q 5-10 years, pending findings – h/o polypectomy and/or resection of CRC

Postpolypectomy Surveillance Colonoscopy Recommendations - 2006 Update

• • • • • – – Small rectal hyperplastic polyps nl colonoscopy, 10-year f/u Hyperplastic polyposis syndrome should be screened more frequently – <2 small tubular adenomas with LGD 5-10 years – – 3-10 adenomas, any >1cm, any with villous features or HGD 3 year f/u if completely removed Subsequent 5 year f/u if nl or above – > 10 adenomas f/u <3 years and consider familial syndrome – – Piecemeal removal of sessile adenomas Repeat endoscopy in 2-6 months After complete removal confirmed, subsequent surveillance based on judgment Winawer SJ, et al. CA Cancer J Clin 2006;56:143-159

Postcancer Resection Surveillance Colonoscopy Recommendations - 2006 Update

• • • – High quality perioperative colonoscopy • Consider CT colonography or DCBE for obstructing lesions Consider colonoscopy 3-6 mo post-op lesions to clear synchronous – – Colonoscopy within 1 year of perioperative clearance 3-year f/u if this exam nl, then 5 year f/u if 3-year exam nl For abnormal findings, stratify by risk – Consider q3-6 month proctoscopy after LAR x 2-3 years Independent of surveillance colonoscopies for metachronous disease

ACS recommendations for CRC screening among people at “high risk” Risk Category

FH of FAP FH of HNPCC Inflammatory Bowel Disease

Age to Begin

Puberty 21 8 years after pancolitis or 12 15 years after left colitis

Recommendation Comment

Early endoscopic surveillance and genetic counseling/testing Colonoscopy & genetic counseling/testing Colectomy for (+) genetic testing If genetics (+) or unavailable, colonoscopy; q1-2 years until 40, then annually Colonoscopy with biopsies of dysplasia q1-2 years Prophylactic colectomy for persistent dysplasia Adapted from Smith RA, et al. CA Cancer J Clin 2001:51:38-75

Emerging Technology

• •

CT (“virtual”) colonography

– May be used in cases of failed or incomplete colonoscopy or in cases of obstructing cancer – Accepted as a screening tool – Medicare will not pay for it – High rate of false positives – Need colonoscopy if positive

Stool DNA mutation testing

– Uses multicomponent DNA-based stool assay targeting point mutations at hot spots on colon oncogenes (i.e.

K-ras, APC

, and

p53

genes) – Single stool sample needed, DNA shed continuously – Multicenter study by Colorectal Cancer Study Group in average risk patients: • Fecal DNA panel v. FOBT • Fecal DNA more sensitive in detecting adenomas and cancer, equal specificity – Not yet accepted as a screening tool • Large stool collection kits; requires entire stool sample • Expensive >$400/test; additional markers increases cost

Outreach Efforts (CRC)

• 2006 = 5, 2007 = 9; 2008 = 5; 2009 = 6

– CRC and skin outreach are least developed programs

• Colonoscopies:

– 2006 = 4945; 2008 = 5756

• 225 new CRC diagnosed 2006 – 2008

– No change in stage distribution

Key Points

• Colon cancer is common in the U.S.

• Prevention and early detection save lives.

• Everyone over 50 should undergo colon cancer screening as part of annual exam.

• Education improves screening.

Improving CRC Outcomes

• Be familiar with CRC screening guidelines • Meet people where they are with outreach • Target underserved areas • Continue to advocate for CRC screening legislation • Emphasize prevention/healthy habits • Use patient educators, “testimonials”