Transcript SURGICAL TREATMENT OF FOCAL LIVER MASSES
SURGICAL TREATMENT OF FOCAL LIVER MASSES
Department of General and Transplant Surgery Medical University of Lódź P. HOGENDORF
HISTORICAL PERSPECTIVE
1654 Francis Glisson – anatomy of th blood vessels of the liver 1716 Berta – first described partial hepatectomy (stab wound, resection of portion of protruding liver) 1908
J. Hogarth Pringle – Pringle's manoeuvre 1957 – Couinaud - descriptions of the segmental nature of liver anatomy 1950's operative mortality rate – 20 % !
1980's operative mortality rate – less than 5 %
Prometheus and Caucasian Eagle
PYOGENIC ABSCESS
Incidence 22/100.000 hospital admissions
11 cases per million / year
male-to-female ratio is approximately 1.5 to 1
Potential routes of hepatic exposure to bacteria:
biliary tree,
portal vein,
hepatic artery,
nearby focus of infection,
trauma
Pathology and Microbiology:
¾ involve
right lobe of the liver ½ of hepatic abscesses are solitary
10% to 20% are sterile abscesses
40 % are polymicrobial
Most common: E. coli & K. pneumoniae S. aureus, E. species, S. viridans, and Bacterioides species
Presenting symptoms of hepatic abscess:
fever,
jaundice (25%),
right upper quadrant pain and tenderness (40-70%)
hepatomegaly all of the above presentation is present only 10% fever, chills, and abdominal pain are the most common
nonspecific symptoms (malaise, vomiting, diarrhea, cough, dyspnea, peritonitis secondary to rupture)
Leukocytosis 70% to 90%
Abnormalities of LFTs
Hypoalbuminemia
mild elevations of the prothrombin
ALP is mildly elevated in 80% total bilirubin is elevated 20% to 50%
Transaminases are mildly elevated about 60%
The sensitivity of ultrasound in diagnosing hepatic abscess is 80% to 95%.
The sensitivity of CT in diagnosing hepatic abscess is 95% to 100%.
MRI does not appear to have any distinct advantage over CT in diagnosing hepatic abscess.
CT: necrtic mass with gas formation in right lobe liver
Differential Diagnosis
differentiating pyogenic abscess from other cystic infective diseases of the liver is important –
amebic abscess
echinococcal cysts differences in intreatment
simple cyst
Polycystic Liver Disease
TREATMENT
percutaneous catheter drainage has become the treatment of choice for most patients
percutaneous aspiration without the placement of a drain
liver resection
broad-spectrum antibiotics covering gram-negative and gram-positive organisms and anaerobes:
ampicillin + an aminoglycoside + metronidazole third-generation cephalosporin with metronidazole carbapenems
mortality from 10% to 20%
Amebic Abscess
WHO estimated that 40 to 50 million people suffer from amebic colitis or amebic liver abscess worldwide 40,000 to 100,000 deaths each year
E. histolytica
other E. species nonpathogenic
Clinical Features
20 to 40 y old patient who has traveled to an endemic area male-to-female ratio: > 10:1 fever, chills, anorexia, right upper quadrant pain, and tenderness and hepatomegaly. 1/3 patients have diarrhea despite an obligatory colonic infection. jaundice is a rare presentation. weight loss and myalgias the abdominal pain is typically constant, dull, and localized to the right upper quadrant.
symptoms and tenderness may be epigastric or left sided if the abscess is located in the left pleuritic or shoulder pain can occur if there is irritation of the diaphragm.
Laboratory tests
moderate leukocytosis
anemia is common.
mild abnormalities of LFTs including albumin, prothrombin time, ALP, AST, and bilirubin levels are typical
antiamebic antibodies that are present in 90% to 95% of patients.
the EIA has a reported sensitivity of 99% and specificity greater than 90% in patients with hepatic abscess.
Radiologic studies
US has a reported accuracy of approximately 90% when combined with a typical historyand clinical presentation
CT is probably more sensitive than US, helpful in differentiating amebic from pyogenic abscess
Nuclear medicine studies such as gallium scanning or technetium 99m liver scans
Treatment
Metronidazole (750 mg orally 3x per day for 10 days) curative in over 90% clinical improvement is usually seen within 3 days
The mortality for all patients with amebic liver abscess is 2% to 4% When an abscess ruptures the mortality is reported to be from 6% to as high as 50%.
Differential diagnosis of amebic and pyogenic abscess
Hydatid Cyst
zoonosis that occurs primarily in sheep-grazing areas of the world
endemic in Mediterranean countries, the Middle East, the Far East, South America, Australia, New Zealand, and East Africa
the dog is a definitive host
no human-to-human transmission
E. granulosus
E. multilocularis and E. oligartus
¾ of hydatid cysts are located in the right liver ¾ are singular
Echinococcus alveolaris
Dogs are the definitive host of
E. granulosus,
in which the adult tapeworm is attached to the villi of the ileum. Eggs are passed (up to thousands of ova daily) and deposited with the dog’s feces. Sheep are the usual intermediate host, but humans are an accidental intermediate host. Humans are an end stage to theparasite. In the human duodenum, the parasitic embryo releases an oncosphere containing hooklets that penetrate the mucosa, allowing access to the bloodstream. Inthe blood, the oncosphere reaches the liver (most commonly) or lungs, where the parasite develops its larval stage known as the hydatid cyst
The most common presenting symptoms are:
abdominal pain, dyspepsia, and vomiting. hepatomegaly is the most frequent sign
jaundice - 8%
fever - 8%
rupture of the cyst into the biliary tree or bronchial tree or free rupture into the peritoneal, pleural, or pericardial cavities can occur.
Free ruptures can result in disseminated echinococcosis and/or a potentially fatal anaphylactic reaction.
Treatment
primarily surgical
albendazole or mebendazole is effective in 20% to 30% of patients
but in elderly patients with small, asymptomatic, calcified cysts,conservative management is appropriate
chemotherapy should generally be considered for widely disseminated disease or patients with poor surgical risk
Recurrence rates after surgical treatment is less than 5 % in experienced centers
NEOPLASMS
Solid Benign Neoplasms
Liver cell adenoma (LCA)
Hemangioma
Focal Nodular Hyperplasia
Other Benign Tumors
Liver Cell Adenoma predominantly found in young women aged 20 40
upper abdominal pain is common relatively rare chronic oral contraceptive use dramatically increases the incidence of this tumor female-to-male ratio is approximately 11:1
dramatic presentations with free intraperitoneal rupture and bleeding can occur quantifying the risk of rupture is difficult but it has been estimated to be as high as 30% to 50% and may be related to size usually singular (multiple in 12% to 30%)
malignant transformation into HCC AFP level is normal
Liver Cell Adenoma
CT
well-circumscribed heterogeneous mass.
MRI
a well-demarcated mass containing fat or hemorrhage
primarily surgical treatment of symptomatic LCA (limited resections can be performed) acute hemorrhage need emergent operation
Liver Cell Adenoma
Histology of hepatic adenoma arranged in plates that are two to three cells thick, separated by sinusoids Macroscopic aspect of liver adenoma with large intralesional hemorrhage
Focal nodular hyperplasia (FNH)
second most common benign tumor of the liver
FNH is usually a small (<5cm) nodular mass
central fibrous scar with radiating septa - 85 %
etiology is not known
persistent symptomatic FNH or an enlarging mass should be considered for resection
physical examination is usually unrevealing, and mild abnormalities of LFT may be found.
AFP level is normal
rupture, bleeding, and infarction are exceedingly rare
No malignant transformations
Contrast medium –enhanced CT MRI
Focal nodular hyperplasia (FNH)
Contrast medium –enhanced CT: A delayed scan showed a non-enhancing scar with subtle enhancement of the capsule of the tumor MRI: on T2W image, mass appeared hypointense whereas the scar was hyperintense.
Focal nodular hyperplasia (FNH)
Focal nodular hyperplasia with characteristic central fibrous region (arrow) and radiating fibrous cords Histology of a central stellate scar in FNH demonstrating thick-walled vessels (arrow) of a large arterial malformation surrounded by fibrous tissue
Hemangioma
the most common benign tumor of the liver Female-to-male 3:1 mean age of about 45 usually singular Usually less than 5 cm in diameter occur equally in the right and left liver > 5 cm are called arbitrarily “giant” hemangioma Large compressive masses may cause vague upper abdominal symptoms.
Spontaneous rupture of liver hemangiomas is exceedingly rare.
An associated syndrome of thrombocytopenia and consumptive coagulopathy known as Kasabach-Merritt syndrome is rare but well described LFTs and tumor markers are normal
Hemangioma
Cut section of two large hepatic hemangiomas showing central fibrosis and hyalin changes (arrows)
Hemangioma
Radiological investigations: # Single-photon emission computed tomography (SPECT) # MRI # CT scan of the liver # Hepatic angiogram Post-contrast MR imaging of the liver demonstrating nodular peripheral enhancement of the right hepatic lobe lesion. First image demonstrates completely hypointense rounded lesion, which shows peripheral enhancement in the subsequent phases. This enhancement pattern is typical for liver venous malformations ("cavernous hemangiomas")
Other Benign Tumors
Nodular regenerative hyperplasia (NRH)
Mesenchymal hamartomas (Mhs)
Lipomas
Leiomyomas
Myxomas
Schwannomas
Lymphangiomas
Teratomas
Primary Solid Malignant Neoplasms Hepatocellular Carcinoma
most common primary
risk factors: HBV infection, HCV
malignancy of the liver over 1 million deaths annually worldwide clearly related to the incidence of hepatitis B virus (HBV) infection
infection, cirrhosis, smoking, alcohol abuse,
age, chronic exposure to carcinogens such as aflatoxin, nitrites, hydrocarbons, solvents, pesticides, and vinyl chloride etc.
The highest incidence of disease (greater than 10 to 20 per 100,000) is found in Southeast Asia and tropical Africa
inherited metabolic liver diseases such as hereditary hemochromatosis, a1 -antitrypsin deficiency, Wilson’s disease the lowest incidence (1 –3 per 100,000) is found in Australia, North America, and Europe.
macronodular cirrhosis
CLINICAL PRESENTATION
right upper quadrant abdominal pain, weight loss, a palpable mass nonspecific symptoms: anorexia, nausea, lethargy hepatic decompensation Usually men 50-60 years of age Rare presentations: rupture with the sudden onset of abdominal pain followed by hypovolemic shock secondary to intraperitoneal bleeding hepatic vein occlusion (Budd-Chiari syndrome) obstructive jaundice, hemobilia, or fever of unknown origin paraneoplastic syndrome, most commonly hypercalcemia, hypoglycemia, and erythrocytosis HCC largely metastasizes to the lung, bone, and peritoneum ,
Cut section of a liver from a patient with Budd Chiari syndrome demonstrating thrombus formation in a large hepatic vein (arrow)
DIAGNOSIS
Radiologic investigation:
CT MRI US Contrast medium – enhanced CT and MRI
Laboratory tests:
AFP level greater than 20 ng/mL in 75 % of HCC
Other:
percutaneous needle biopsies only in non resectable cases
Hepatocellular Carcinoma
Cut surface of a hepatocellular carcinoma without a capsule, infiltrating the liver parenchyma Cut section of a HCC with a mosaic pattern containing fat, solid nodules, necroses, fibrosis and cystic areas
Hepatocellular Carcinoma
Grade 1 HCC may be difficult to distinguish from liver-cell adenomas and atypical hyperplastic nodules Histological aspect of a well differentiated HCC showing bile production (arrows)
Treatment
First step: to stage the tumor
Second step: assessment of liver function
Third step: treatment plan
Liver resection is considered the treatment of choice for HCC
Other successful treatments: - ablative techniques, - embolization techniques, - liver
Chemotherapy Hormonal therapy Immunotherapy
Treatment (2)
Patients with advanced cirrhosis (Child’s B and C) and early stage HCC should be considered for transplant, whereas those with Child’s A cirrhosis have similar results with transplant and resection and should probably undergo resection.
Problems: lack of
organ donors and need for chronic immunosuppression
Long-term survival rates in recent years have ranged from 25% to 75% .
Cholangiocarcinoma
uncommon neoplasm
1 to 2 per 100,000 in the United States
can develop anywhere along the biliary tree
40-60 % involve the biliary confluence (Klatskin’s tumor) risk factors:
primary sclerosing cholangitis,
choledochal cyst disease,
recurrent pyogenic cholangitis.
The clinical presentation of IHC is similar to that of HCC.
If completely resected, 3-year survival rates range from 16% to 61% and 5-year survival rates range from 24% to 44%.
Other Primary Malignant Neoplasms
Hepatoblastoma
Sarcomas Non Hodgkin’s lymphoma
Malignant germ cell tumors
Primary hepatic lymphoma
neuroendocrine tumors
Epithelioid hemangioendothelioma
Hodgkin’s disease
Metastatic Tumors
The most common malignant tumors of the liver are metastatic lesions:
colorectal cancer
tumors of the lung,
prostate,
breast,
pancreas,
stomach,
kidney,
cervix and ovary
liver is a common site of metastases from gastrointestinal tumors
metastatic colorectal cancer isolated in the liver can be resected with the
potential for long-term survival and cure
Colorectal liver metastases
There are over 50,000 cases of colorectal liver metastases a year in the United States Diagnosis
imaging studies (contrast-enhanced-CT, triphasic technique)
LFTs
CEA levels Colonoscopy – rule out local recurrence or metachronous lesions.
Hepatic resections for colorectal liver metastases
is still associated with significant morbidity rates of 30% to 50%
complications are most commonly bleeding, bile leak, abscess, and other generalized cardiorespiratory complications.
Adjuvant systemic chemotherapy after liver resection for metastatic colorectal cancer
hepatic arterial infusion (HAI) chemotherapy.
After resections five-year survival rates range from 25% to 37%, and mortality in experienced centers is consistently less than 5%
Incision
HEPATIC RESECTION
Nomenclature for Major Anatomic Hepatic Resection