Transcript A Look at the Diet

Excess Oxalate Warning
Foods that Enhance Oxalate Excretion
 Wheat Bran
 Avoid excesses of these in green drinks if prone to
 Beets*
kidney stones.
 Calcium inhibits absorption.
 Chocolate

 Nuts
 Tea
 36 patients with recurring oxalate kidney stones
were supplemented with 200 mg Mg and 10 mg B6
for 5 years. 30 had no recurrence or decreased
stone formation.
 Spinach*
 Swiss Chard*
 Strawberries
 Rhubarb
Massey, Linda K., et al., Effect of dietary oxalate and calcium on urinary
oxalate and risk of formation of calcium oxalate kidney stones, Journal of the
American Dietetic Association, August 1993; 93(8):901-906.

Gershoff, Stanley, et al., Effect of daily MgO and vitamin B6 administration to
patients with recurring calcium oxalate kidney stones, Am J Clin Nut, May
1967; 20(5):393-399.
Organic
vs
Commercial Agriculture
Polyphenols vs. Flavonoids
Polyphenols (8,000+)





Flavonoids (4,000 +)
Phenolic acids
Stilbenes
Tannins
Diferuloylmethanes
Flavonoids (4,000+)
 Anthocyanins
 Flavonols
 Flavanones
 Flavonols
 Flavones
 Isovlavones
 All flavonoids are polyphenols but not all polyphenols are flavonoids.
Flavonoids are the largest family of polyphenolic compounds. The names
are often used interchangeably.
Suggested Biological Effects of Polyphenols
 Antimutagenicity
 Antibacterial
 Anticarcinogenicity
 Antiviral
 Antiaging
 Anti-inflammatory
 Antiallergic
 Antithrombotic
Velioglu, Y.S., et al., Antioxidant activity and total phenolics in selected fruits, vegetables, and grain
products, J. Agric. Food Chem., 1998;46:4113-4117.
Polyphenol Loss with Conventional Farming
 “All organic peach
 Organic grapes were shown to
have 2 times the levels of
polyphenols found in
conventional produce. “This
increase…may contribute
effectively to disease resistance
in organic farming…” (ie. less
pesticide use)
samples showed a highly
significant (P>0.01)
increase in polyphenols
compared with
conventional peaches.”

Carbonaro, Marina and Mattera, Maria,
Polyphenoloxidase activity and polyphenol
levels in organically and conventionally
grown peach and pear, Food Chemistry,
March 2001; 72(4):419-424.

Nunez-Delicado, Estrella, et al., Effect of organic farming
practices on the level of latent polyphenol oxidase in
grapes, Journal of Food Science, 2005;70(1). Web
Publication.
Total Phenolics
 “…the total phenolic (TP) content of marionberries,
strawberries, and corn grown by sustainable,
organic, or conventional cultural practices were
measured…Statistically higher levels of TPs were
consistently found in organically and sustainably
grown foods as compared to those produced by
conventional agricultural practices.

Asami, Danny K., et al., Comparison of the Total Phenolic and Ascorbic Acid
Content of Freeze-Dried and Air-Dried Marionberry, Strawberry, and Corn
Grown Using Conventional, Organic, and Sustainable Agricultural Practices,
Journal of Agriculture and Food Chemistry, Jan 25, 2003;51:1237-1241.
Flavonoids in Tomatoes
 Ten-year mean levels of quercetin and
kaempferol in organic tomatoes were
79 and 97% higher than those in
conventioal tomatoes, respectively.
The levels of flavonoids increased over
time in samples from organic
treatments, whereas the levels of
flavonoids did not vary significantly in
conventional treatments.

Barrett, Diane M., et al., Ten-year comparison of the
influence of organic and conventional crop management
practices on the content of flavonoids in tomatoes, J.
Agric. Food Chem., 2007;55:6154-6159.
Carpal Tunnel Syndrome
A pinched nerve in the wrist which causes numbness,
tingling and other symptoms in the hand and arm.
Carpal Tunnel Syndrome
 Karl Folkers and John
Ellis identified a
deficiency of vitamin B6.
Improvement takes
place in 10-12 weeks
when adequate B6 and
co-factors (including B2)
are supplied (generally
about 50 mg.).
B Complex Deficiency
General Causes
B6 antagonists
 Genetic and epigenetic defects --
 Food coloring (Yellow #5)
At least 5 metabolic abnormalities
that respond to vitamin B6
supplements have been reported.
 Competitive antimetabolites —
bind more tightly to the receptor
site than the vitamin.
 Noncompetitive antimetabolites -can not be driven away by the
vitamin.
 Acquired Dependency
 Herbicides
 Plant growth regulators (growth




inhibitor on potatoes & onions &
ripening agents)
Prescription medications (birth
control pill)
Hydrazines (rocket fuel, smoking,
medications for TB, depression,
high blood pressure)
PCB’s
Overheated vegetable oils
Mauve Factor or HPL
HPL or Mauve Factor
 Correlates with emotional and oxidative
HPL is unstable
outside the body and
destroyed by light.
stress
 Associated with intestinal permeability.
Prednisone provokes.
 Antibiotics reduce suggesting bacterial
overgrowth is involved in its production or
the production of a precursor.
 Zinc and vitamin B6 reduce urinary
excretion

McGinnis, W.R., et al., Discerning the Mauve Factor, Part 1,
Altern Ther Health Med, Mar-Apr 2008;14(2):40-50. (Part 2 MayJune)
Mauve Factor: HPL
Schizophrenics
 Acute first admission: 90%
 Acute first and readmissions: 75%
 Treated still ill: 50%
 Treated and well: 0%
Now identified as HPL (hydroxyhemopyrrolin-2-one)
 Misidentified in the literature as kryptopyrrole
 Inversely associated with vitamin B6 and zinc levels in red
blood cells
 Causes abnormal perception

McGinnis, W.R., et al., Discerning the Mauve Factor, Part 1, Altern Ther Health
Med., Mar-Apr 2008;14(2):40-50.
Neurobehavioral Disorders associated with Elevated HPL
 Down syndrome 71%
 Adult sudden deviance criminal



Signs of B6 and Zinc Deficiency
Poor dream recall, morning
nausea or anorexia
White spots on nails, stretch
marks





behavior 71%
Youth violent offenders 33%
Manic depression 47-50%
Non-schizophrenic depression
12-46%
Autism 46-48%
Epilepsy 44%
ADHD 40-47%
Alcoholism 20-84%
Substance abuse 75%
Vitamin D
and
Brain Function
Vitamin D and Brain Development
 “…vitamin D acts as a
neurosteroid with direct
effects on brain
development.”

Eyles, D.W., et al., Developmental vitamin D
deficiency causes abnormal brain
development, Psychoneuroendocrinology,
2009;345:5247-5257.
B Complex and Folic Acid
Folic Acid Detoxification of Arsenic & Alcohol
Infertility & Heart Disease
Omega-3 and Diabetes
Omega-3 in Diabetes and Obesity
 Derivatives of omega-3 fatty
acids are important
regulators of inflammation
in obesity and diabetes.
These compounds
prevented and even
reversed the effects of
diabetes in obese mice.

Hammock, Bruce D., et al., Inhibition of soluble
epoxide hydrolase modulates inflammation and
autophagy in obese adipose tissue and liver: Role
for omega-3 epoxides, PNAS. Cristina LópezVicario, doi: 10.1073/pnas.1422590112
Cancer Research
Omega-3 & Cancer
 A product of metabolized DHA, an omega-
3 fat, helps combat cancer by cutting off
the supply of oxygen and nutrients that fuel
tumor growth and the spread of the
disease. The product is called epoxy
docosapaentaenoic acid and it blocks
angiogenesis. A metabolite of arachidonic
acid had the opposite effect.

University of California - Davis Health System. "Fatty acid
metabolite shows promise against cancer in mice." ScienceDaily.
ScienceDaily, 2 April 2013.
<www.sciencedaily.com/releases/2013/04/130402143944.htm>.
Soy and Cancer
 “Soybeans are a unique source of the isoflavone
Tyrosine kinases
stuck in the “on”
position
(promoting
unregulated cell
growth) are a
necessary step in
the development
of cancer.
genistein, which possesses weak estrogenic activity
and has been shown to act in animal models as an
antiestrogen. Genistein is also a specific inhibitor of
protein tyrosine kinases; it also inhibits DNA
topoisomerases and other critical enzymes involved
in signal transduction. In vitro, genistein suppresses
the growth of a wide range of cancer cells…”
 “Protective effects were observed for both hormone
and nonhormone-related cancers.”


Messina, Mark J., et al., Soy intake and cancer risk: A review of the in vitro and
in vivo data, Nutrition and Cancer, 1994;21(2):113-131.
http://en.wikipedia.org/wiki/Tyrosine_kinase
Lunasin
Prostate and breast cancers are 4-10
times more common in the U.S. than in
southeast Asia. Rates become identical
within one generation of moving to the
U.S.
“In spite of its cancer-preventative
properties, lunasin does not affect the
growth rate of normal and established
cell lines…lunasin selectively kills cells
being transformed or newly
transformed… leading to cell death.”
De Lumen, Ben O., Lunasin: A Cancer-Preventive Soy Peptide,
Nutrition Reviews, January 2005; 63(1):16-21.
Lunasin
“One of the properties of an
ideal cancer-preventive
agent is that it can be taken
orally.…Pilot studies (of
lunasin) showed that about
35% of the oral dose is
absorbed and ends up in the
various tissues of mice and
rats 6 hours after
administration…”
De Lumen, Ben O., Lunasin: A CancerPreventive Soy Peptide, Nutrition Reviews,
January 2005; 63(1):16-21.
Phytonutrients and Cancer
Allium & Cruciferous
 “As a first step towards the identification of foods
endowed with the most potent chemopreventive
activities, we evaluated the inhibitory effects of
extracts isolated from 34 vegetables on the
proliferation of 8 different tumour cell lines. The
extracts from cruciferous vegetables as well as
those from vegetables of the genus Allium
inhibited the proliferation of all tested cancer cell
lines whereas extracts from vegetables most
commonly consumed in Western countries were
much less effective. The antiproliferative effect of
vegetables was specific to cells of cancerous origin
and was found to be largely independent of their
antioxidant properties.”
Brain and Lung Cancer
Prostate & Pancreatic Cancer
Brain and Kidney Cancer
Breast and Stomach Cancer
Two Powerful Supplements
Parkinson’s Disease
The Detoxification Connection
 Parkinson’s is more common in those with a history of
exposure to agricultural and other toxic chemicals.
 There also appears to be a defect in the ability to
detoxify these substances.

Tanner, C.M., “Liver Abnormalities in Parkinson’s disease,” Geriatrics 46 (1):60-63, 1991.
 Since the late 1980s, a steady stream of studies from
around the world has shown again and again that a
common thread among victims of Parkinson's is a
history of exposure to insecticides and herbicides. Most
recently a study showed that exposure to industrial
solvents is linked to Parkinson's.


J.M. Gorell, "The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living,"
NEUROLOGY Vol. 50, No. 5 (May 1998), pgs. 1346-1350.
A. Smargiassi and others, "A case-control study of occupational and environmental risk factors for Parkinson's disease in
the Emilia-Romagna region of Italy," NEUROTOXICOLOGY Vol. 19, Nos. 4-5 (August-October 1998), pgs. 709-712.
The Detoxification Connection
 In 1976 Barry Kidston, a 23-year-old chemistry
student, synthesized MPPP (an opioid) contaminated
with MPTP. He self-injected and began experiencing
symptoms of Parkinson’s 3 days later. Autopsy 18
months later showed destruction of the substantia
nigra (part of the brain).

http://en.wikipedia.org/wiki/MPTP
 In the 1980’s a recreational drug (meperidine)
similar in chemical structure to several pesticides and
herbicides was shown to cause symptoms of
Parkinson’s in young people.

J.W. Langston and others, "Chronic Parkinsonism in humans due to a product of
meperidine-analog synthesis," SCIENCE Vol. 219, No. 4587 (February 25,
1983), pgs. 979-980.
Folic Acid Protects
National Institute on Aging (NIA) Study
 Mice on a low intake of folic acid had an 8-fold increase
in homocysteine
 Exposure to MPTP, a chemical that causes Parkinson’s
created symptoms of the disease in deficient mice.
 Mice on a diet with adequate folic acid were resistant to
the chemical.
 Folic acid protects adult nerve cells from age related
disease.
 Injection of homocysteine directly into the brain
increased symptoms dramatically.
 Folic acid deficiency by itself did not cause Parkinson’slike problems.
Abstract January 2002
The ability of folate deficiency and elevated
homocysteine levels to sensitize dopaminergic
neurons to environmental toxins suggests a
mechanism whereby dietary folate may influence
risk for PD.
Wenzhen Duan, Bruce Ladenheim , Roy G. Cutler, Inna I. Kruman,
Jean Lud Cadet and Mark P. Mattson, “Dietary folate deficiency and
elevated homocysteine levels endanger dopaminergic neurons in models
of Parkinson's disease,” Journal of Neurochemistry, Vol. 80, No. 1,
January 2002 101-110
Riboflavin
 Researchers in Brazil found that 31 Parkinson’s patients they
tested were deficient in riboflavin (vitamin B2). Supplementation
of 19 of these for 6 months with 30 milligrams of vitamin B2 3
times a day improved functional motor capacity from 44% of
normal to 71% of normal. Patients were also instructed to
discontinue eating red meat, which releases hemin, a potential
neurotoxin, during the process of digestion.

Coimbra, C. G., et al, High doses of riboflavin and the elimination of dietary red meat promote the
recovery of some motor functions in Parkinson’s disease patients, Braziliean Journal of Medical and
Biological Research, 2003; 36(10):1409-1417.
Key Supplements for Prevention of Parkinson’s
Prostate Problems
Prostatic Hyperplasia
Definitions: Hyperplasia-increase in the number of cells. Hypertrophyincrease in the size of the cells.
BPH: Benign Prostatic Hyperplasia
 10% of men in their 20’s and
30’s
 50% of men under 60.
 90% of men over 80
 Prostrate surgery is the 2nd
most common surgery in
America after cataract
surgery.

Firshein, Richard, The Nutraceutical
Revolution, New York: Penguin Putnam,
1998, 299-302.
Nature of the Problem
 The prostate surrounds the first inch of the
urethra, the thin tube that carries the urine to the
bladder.
 The prostate often becomes enlarged or swollen as
men age. Symptoms: frequent urination, urinary
frequency, burning while urinating, dribbling.

http://commons.wikimedia.org/wiki/File:Hypertrophy_of_the_interuretal_fold_of_a_bladder_Wellcome_L0061771.jpg
Complications
 Kidney damage
 Kidney stones
 Urinary retention
 Insomnia
Causes of BPH
 BPH is associated with metabolic
syndrome. “The findings generate a
hypothesis of a causal relationship
between high insulin levels and the
development of BPH.”
 Associated factors: diabetes, obesity, high
insulin, low HDL levels.

Hammarsten, J., et al., Components of the metabolic syndromerisk factors for the development of benign prostatic hyperplasia,
Prostate Cancer and Prostatic Diseases, 1998;1(3):157-162.
Causes of BPH: Bisphenol A
 Bisphenol A (an estrogenic plastic ingredient) at low
doses induced the prostate of rats to proliferate and
aggravated testosterone-induced benign
hyperplasia.
 Adverse effects of low-dose estrogenic chemicals
(bisphenol A, octylphenol, diethylstilbestrol)
“include oviduct rupture, an enlarged prostate,
feminization of males and reduced sperm quality.”


Wu, Jian-Hui, et al., Oral exposure to low-dose bisphenol A aggravates
testosterone-induced benign hyperplasia prostate in rats, Toxicology and
Industrial Health, October 2011; 27(9):810-819.
Weltje, Lennart, et al., Reproductive stimulation by low doses of
xenoestrogens contrasts with the view of hormesis as an adaptive response,
Human and Experimental Toxicology, 2005;24:431-437.
Causes of BPH
 BPA increases the
estradiol/testosterone ratio and
aromatase. Aromatase is a key
enzyme involved in estrogen
synthesis.

Castro B, Sánchez P, Torres JM, Preda O, del Moral RG, et al. (2013)
Bisphenol A Exposure during Adulthood Alters Expression of Aromatase
and 5α-Reductase Isozymes in Rat Prostate. PLoS ONE 8(2): e55905.
doi:10.1371/journal.pone.0055905
Causes of BPH:DHT
 Persistent bacterial infection.
 Transformation of testosterone to DHT
(dihydrotestosterone) by other
hormones (that rise as men age. The
enzyme 5-alpha-reductase converts
testosterone to DHT. DHT is 10 times
stronger than testosterone because it
clings to the androgen receptor longer.
 Castrated boys do not develop BPH.
Medical Treatments
Drugs
Surgery
 α-adrenergic blocking agents or
 TURP: trans-urethral
alpha blockers. These drugs are
muscle relaxants (terazosin,
alfuzosin, tamsulosin, silodosin)
 5 α-reductase inhibitors block
DHT formation. Finasteride &
dutasteride, are pharmaceutical
to treatments for BPH.
 Aromatase inhibitors: Block
production of estrogen.
(Atamestane)
resection of the prostate (2nd
most common surgery in
America). Involves boring a
hole through the enlarged
prostate.
 Prostatectomy: Removal of
the prostate.
Natural 5-alpha Reductase Inhibitors
 Zinc
 St. John’s wort
 Vitamin B2
 GLA
 Beta-sitosterol
 Alpha-linolenic acid
 Polyphenols
 Curcumin
 Green tea catechins
 Chinese Knotweed
 Saw Palmetto (Dual
inhibition activity)
 Reishi mushroom







(flax oil)
MCT (coconut oil)
Peppermint
Sage
Hops
Genistein and
daidzein (soy)
Resveratrol
https://en.wikipedia.org/wiki/5alpha-reductase_inhibitor
Supplements
• Zinc
• B Complex
• Tre-en-en
• Tre
• Flavonoid
Complex
• Masculine Herbal
• NeoLife Shake
(soy)
Natural inhibitors of Aromatase
 Zinc
 Vitamin E
 Catechin
 Chalcones
 Apigenin
 Eriodictyol
 Isoliquiritigenin
 Mangostin
 Myosmine
 Nicotine
 Resveratrol

https://en.wikipedia.org/wiki/Aromatase
Exercise and BPH
 There is a strong inverse
relationship between exercise and
the development of BPH and lower
urinary tract symptoms.

Sea, J., et al., Review of exercise and the risk of benign
prostatic hyperplasia, The Physician and Sportsmedicine,
2009;37(4):75-83.
Backward Pressure on Venous System
 “We found that in all BPH patients, the
Gat, Y., et al., Reversal of benign prostate
hyperplasia by selective occlusion of impaired
venous drainage in the male reproductive system:
novel mechanism, new treatment, Andrologia,
2008;40:273-281.
one-way valves in the…spermatic veins
are destroyed…causing elevated
hydrostatic pressure, some 6-fold
greater than normal…we found that
free testosterone levels in this blood are
markedly elevated, with a concentration
of some 130-fold above serum level.”
 The pressure causes prostate cells to
swell and the testosterone causes the
number of cells to increase. Elimination
of the back pressure caused rapid
regression of symptoms.
Back Pressure on Venous System
 Destruction of the
one way valves in the
veins reaches 75% at
the age of 70.
Impaired venous flow here
builds pressure and hormone
levels in prostate tissue.
Aggravated by lack of
exercise, weight gain, and
weak connective tissue.
Prostate
Home Treatment Tips
 Practice double voiding
 Avoid caffeine and
alcohol which increase
urination
 Antihistamines,
decongestants, and
allergy pills make
urination difficult.
Migraine
Migraine
 12 of 21 children with migraine and
bedwetting problems improved on an
elimination diet. 8 relapsed after
reintroduction of the offending foods.

Garlic and acidophilus
suppress.

Egger, J., M.D., et al, "Effect of Diet Treatment on
Enuresis in Children With Migraine or Hyperkinetic
Behavior", Clinical Pediatrics, May 1992;302-307.
 50% of migraine sufferers improved
with elimination of specific foods
although prick tests and blood IgE
levels were normal.

 Candida albicans overgrowth.
Nattero, Giovanni, et al, "Dietary Migraine as Adverse
Reactions", Cephalalgia, 1989; 9(10):193-194.
Heuser, Gunnar, M.D., Ph.D., et al, "Candida
Albicans and Migraine Headaches: A
Possible Link", Journal of the Advancement
in Medicine, Fall 1992;5(3):177-187.
 Melatonin supplementation
reduced frequency.

Peres MFP, Zukerman E, et al, "Melatonin, 3
mg, Is Effective for Migraine Prevention,"
Neurology, August 2004;63(2 of 2):757.
Sleep Quality and Melatonin
 Ear plugs and eye
masks significantly
elevated melatonin
in the intensive care
unit (ICU).
Melatonin is a
simple derivative of
tryptophan.

"Melatonin: Hormone of Darkness",
Editorial, British Medical Journal,
1993;307.
Migraine and Mitochondrial Energy
 Red blood cell magnesium levels are
 Case report of 2 individuals who
low in migraine sufferers.
Supplementation produces benefits.

Gallai, Virgilio, et al, "Red Blood Cell Magnesium Levels in
Migraine Patients", Cephalalgia, 1993;13:94-98.
were able to relieve migraine pain by
taking 500 mg of niacin.

 49 patients with migraine were given
400 mg B2 before breakfast for 3
months. Headache scores improved
by 68%.

Prousky JE, Sykes E, "Two Case Reports on the
Treatment of Acute Migraine With Niacin: Its
Hypothetical Mechanism of Action Upon CalcitoninGene Related Peptide and Platelets," J Orthomol Med,
2003;18(2):108-110.
 About 75% of young migraine
sufferers were deficient in CoQ10.
Supplementation reduced frequency
and severity.
Schoenen, J., et al., High-dose riboflavin as a
prophylactic treatment of migraine: Results of an
open pilot study, Cephalalgia , October 1994 ;
14(5):328-329

Hershey AD, Powers SW, et al, "Coenzyme Q10
Deficiency and Response to Supplementation in
Pediatric and Adolescent Migraine," Headache, 2007;
47(1): 73-80.
Migraine
 Scientists from the Genomics Research
Centre (GRC) at Griffith University in
Brisbane investigated giving 52 migraine
sufferers supplements that lower
homocysteine (B6 [25 mg], B12 [400 mcg]
and folic acid [2 mg]). These levels are at
least 10X RDA levels. Homocysteine levels
were reduced by 39%. Reduction in migraine
disability went from 60% at the start of the
study to 30% after 6 months.

Lea, Rod, et al., The effects of supplementation and MTHFR
(C677T) genotype on homocysteine-lowering and migraine
disability, Pharmacogenetics and Genomics, June 2009;
19(6):422-428.
 Other supplements involved in methylation:
TMG (betaine), zinc, vitamin B2)
The End