Transcript Sarcoidosis - University of California, Irvine

Sarcoidosis
Bryan Imayanagita
10/22/10
UCI T-RAP
Background
Besnier-Boeck disease
 Abnormal collection of inflammatory
granulomas
 20-40 years year old. Scandinavian,
blacks
 Commonly affects lungs

Pathophysiology
Exact cause unknown
 accumulation of monocytes, macrophages
and activated T-lymphocytes
 Macrophage increase inflammation while
immune response suppressed
 Genetic Factors: BTNL-2 gene (possibility)

Symptoms
Signs often vague and hard to distinguish
 Fatigue, aches, pains, rashes
 Enlarged lymph nodes
 Mimics cancer
 Can be asymptomatic

Diagnosis
Process of elimination
 CT, chest X-ray, PET scan to exclude in
pulmonary cases
 Differential diagnosis: metastatic disease,
lymphoma, septic emboli, etc
 Women: association with
hypo/hyperthyroidism

Stage IV Sarcoidosis
Treatment
30-70% don’t require treatment
 Corticosteroids (prednisone)
 Follow up: EKG, liver, calcium tests

Prognosis
Can remit spontaneously or become
chronic
 Half cured in 12-36 months. Most in 5
years
 heart problems
 Higher cancer risks

Sources
http://www.merck.com/mmhe/sec04/ch050
/ch050e.html
 http://www.nhlbi.nih.gov/health/dci/Disease
s/sarc/sar_signsandsymptoms.html
 http://www.medicinenet.com/sarcoidosis/ar
ticle.htm
