Transcript Использование математического анализа

SYSTEM INDIVIDUAL MONITORING
OF FUNCTIONAL AND ADAPTIVE
HUMAN RESERVES
Konstantin Apykhtin, Ph.D., M.D., Institute for Occupational Health of NAMS of Ukraine, Kyiv
Vladimir Petrukhin, Prof., Dr. ; Sabir Shaykhlislamov, Anton Danshin, AlexeyZapara, Moscow
Institute of Physics and Technology, Department of Control and Applied Mathematics
• According to the WHO Constitution, "Health is a
state of complete physical, mental and social wellbeing and not merely the absence of disease or
infirmity“ (1946).
• Health is primarily a state of the organism, which is
characterized by the relation of structure and
function, as well as the ability of regulatory systems
to maintain a constant internal environment
(homeostasis). (Nikolay N. Zajko, Prof., Dr. Med.,
Soviet pathophysiologist, 1908-1991).
• The disease is a disruption of the normal functioning
of the body when exposed to damaging agents,
resulting in a decrease of its adaptive capabilities
(Nikolay N. Zajko).
• The disease is a dynamic state of an organism
characterized by disruption of normal flow of life
processes, resulting in reduced biological and social
abilities of a person.
Health
?
Disease
Health
Prenosological
changes
Disease
The levels of the
organization
Temporary
Informational
Energy
Functional
Structural
Biorhythms, coherence
phase processes
in time
Neuro-humoral
regulation.
The hormone-receptor
and synaptic
interaction.
ATP synthesis in
mitochondria,
the reactions of
glycolysis.
The functioning of
the organs and
systems of the
body
Cell organelles,
components,
membranes, structural
proteins, enzymes, DNA
The sequence of development of pathological process
Temporary level
Informational level
Energy level
Functional level
Structural level
1
2
3
4
5
The time of occurrence of violations
Prenosological approach
• Proposed by Soviet scientists Roman M. Baevsky,
Vasily V. Parin and other (1966).
• Based on the analysis of subtle changes in the
temporal organization of control actions of the
nervous and endocrine systems on chronotropic
function of the sinus node of the heart.
• Assumes a three-level hierarchical model of heart
rhythm control.
Levels:
III.
II.
subcortical
sympathetic
ergotrop nerve
centers
baroreflex center of
the medulla
oblongata
Reaction time:
Spectral domain:
25 – 300 sec
VLF
6 – 25 sec
LF
truncus
sympathicus
I.
n.n.
vagus
2.5 – 6 sec
HF
sequence of P-P (or R-R)
HRV
ECG
R-R
Rhytmogramm (graph of R-R intervals)
Our body works according to the following rules:
• Normally, when the workload or everyday activity demands do not exceed
the capacity of CVS (e.g. rest or light intensity work), the heart is regulated
predominantly by autonomic level.
• When the workload becomes higher, the organism starts to involve
baroreflex level of regulation.
• When the workload becomes too high or external conditions become too
severe, the organism starts to involve sympathetic ergotropic and humoral
level.
• So, the higher intensity of work or adaptation, the higher level of
regulation is involved.
• Each higher level of regulation inhibits activity of lower levels.
• The state of stress is characterized by increased heart rate (HR), increased
sympathetic tone of ANS, increased blood pressure.
• State of relaxation is characterized by decrease of HR, increase of
parasympathetic tone (synonym – vagal tone) of ANS.
Stress-index of Roman M. Baevsky
N
Amplitude of mode (AMo)
n
SI = AMo (%) / (2*Mo*Δ RR)
AMo (%) = n / N * 100%
[Mo] = sec
n
RR min
[ВР] = sec
RR max
0,05 sec
Mode
(Mo)
Range (Δ RR)
RR
Rest : ≈ 50 - 120
Sleep : < 50
Stress : 200 - 1000
Miocardial infarction : 1000 - 2000
Indexes of vagal tone
R-R(i)
R-R(i+1)
RMSSD =
HRV = 20*ln (RMSSD)
Used in USA
CardioMood
website
www.cardiomood.com
CardioMood project: the team
Bluetooth
Site
www.home.cardiomood.com
Bluetooth
System requirements and
compatibility
• Smartphone or tablet requirements:
– OS: Android 4.3+
– Bluetooth: 4.0 Low Energy
• Heart rate sensor:
– Bluetooth Smart (e.g. Polar H7)
HRV Expert for Android
http://bit.do/hrv-expert
Recording screen
History
Report includes time and frequency domain parameters, histogram analysis and
Poincare plot
All calculated values as well as raw data can be exported to a text file
User home page
• All data from smartphone is
synchronized with website
• Profound analysis of RRintervals with HRV methods
• Data export to Excel tables
• User groups and roles
(users and doctors
accounts on
home.cardiomood.com and
doctor.cardiomood.com
respectively)
HRV analysis
• Artifacts filtration
• Different analysis
epochs
• Analysis of selected
area
• Over 20 calculated
HRV parameters
• Data export and
printing
Key features
 Flexible measurement duration limits
 Comprehensive report
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Time-domain parameters (SDNN, RMSSD, pNN50, etc)
Frequency-domain parameters (VLF, LF, HF, etc)
Histogram analysis
Poincare plot analysis
 Artifacts and ectopic beat elimination
 Raw-data export
 Remote real-time monitoring (Internet required)
 Cloud synchronization
Evolution of the modes of transmission of emotions
carrier pigeons
Evolution of the modes of transmission of emotions
Telegraph
Evolution of the modes of transmission of emotions
telephone
cell phone
Evolution of the modes of transmission of emotions
Evolution of the modes of transmission of emotions
CardioMood