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An Overview of the Research Institute 2012-13 Prof Alicia El Haj Director, Institute for Science & Technology in Medicine, Keele University Keele University www.keele.ac.uk A campus-based university located in the West Midlands of England, offering dual-honours degrees and research in science, social science and humanities. Founded as a University College in 1949, it received its Royal Charter in 1962. Research Institute for Science & Technology in Medicine (ISTM) A multidisciplinary Institute formed in 2006 to underpin the new Medical School established between Keele and Manchester Universities Keele Medical School ISTM brings together dispersed clinical and laboratory-based researchers from different departments and cultures. School of Life Sciences University Hospital of North Staffordshire (PFI development) Guy Hilton Research Centre RJ&AH Orthopaedic Hospital Facilitating Biomedical Research ISTM brings together clinicians and bio-scientists across four hospital sites and the Keele campus: • University Hospital of North Staffordshire, Hartshill, Stoke-onTrent • The Haywood Hospital, Burslem, Stoke-on-Trent • Robert Jones & Agnes Hunt Orthopaedic Hospital, Oswestry • Leighton Hospital, Crewe • School of Medicine • School of Pharmacy • School of Health & Rehabilitation • School of Life Sciences • School of Computing & Mathematics • School of Chemistry & Physics ISTM Away Day 2012 Translational Research “bench to bedside” Industrial Partnership Industrial Partnership Potential Clinical application Clinical Trial Basic science Cell biology/ Physics/ Biological Chemistry Bioengineering/ Imaging/ In vitro/ In vivo modelling ISTM - Current Staff • 88 full members: – – – – Professors: 27 Readers, Senior Lecturers, Clinical Lecturers: 40 Lecturers: 18 Research Fellows: 3 • >25 NHS clinicians run clinical trials through ISTM • 9 affiliated members from other Keele RI’s • Key chair appointments of senior clinical/non clinical academics to expand capacity • A large percentage of career-young researchers in the Medical and Pharmacy Schools ISTM - Directors Director Prof Alicia El Haj Deputy Director Prof Paul Eggleston Clinical co-Director Prof Simon Davies Director of Postgraduate Studies Prof Trevor Greenhough ISTM – Scientific themes 2012 review of groupings underway • Bioengineering & Therapeutics • Clinical & Diagnostic Science • Infection, Inflammation & Immunity (incorporating CAEP, the Centre for Applied Entomology & Parasitology) • Neuroscience & Human Metabolism Bioengineering & Therapeutics Theme leaders: Prof Alicia El Haj Prof James Richardson Cellular phenomena and cellular therapies for clinical applications e.g. • Autologous treatments, e.g. knee cartilage • Surgical repair, e.g. biomagnetic cell targeting • Magnetism and magnetic materials techniques for biomedical applications, e.g. in the brain. ISTM is a European Centre of Excellence in Tissue Engineering. Clinical & Diagnostic Science Theme leaders: Prof Gwyn Williams Prof Simon Davies Interaction between bioscientists, engineers, physicists, chemists and clinicians e.g. • Molecular epidemiology and tumorigenesis • Apoptosis (programmed cell death) • Structural biology of the innate immune response • Rheumatic and inflammatory diseases • Breath analysis – monitoring and diagnosis ISTM has a dedicated Human Genomics facility Infection, Inflammation & Immunity Incorporating the Centre for Applied Entomology and Parasitology (CAEP) Theme leader: Prof Gordon Hamilton Molecular approaches to control of insect vector-borne disease • • • • Malaria, mosquitoes and man Leishmania, sandflies and man Chemical ecology of insect communication Fish parasitology & comparative immunology CAEP is an internationally recognised centre with links to North and South America, Africa, Asia and Europe. Neuroscience & Human Metabolism Theme leaders: Dr David Furness Prof Clive Hawkins Multidisciplinary studies of neuroscience, neurological and metabolic disorders • Cellular and tissue engineering to restore damaged areas of the nervous system • Clinical studies of multiple sclerosis and stroke • Sensory neurobiology and plasticity • Cardiovascular disease and its treatment ISTM - Activity Metrics • • • • Manages ~185 live research grants and trials Receives £5m / year income, incl £3.8m in grants Applies for ~150 new research grants / year Outputs ~280 peer-reviewed publications / year • RAE2008: 90% of staff rated of international quality in UoA 25 General Engineering • REF2014: UoA 15 General Engineering UoA 3 Allied Health Professions UoA 5 Biological Sciences Potentially 50-60 academics submitted ISTM Current Major Funding Sources Grant income forecast : ~ £4.5 million + Income (£ million) 5 4 3 2 1% 7% 25% 9% 2% 5% 0% 0% 31% 14% ISTM Research grant income sources 2011/12 RC Charity 1 C Govt L Auth P Corp Industry 0 Health 2008/09 2009/10 2010/11 2011/12 2012/13 Financial Year (Aug-July) HEFCE QR core funding (RAE2008) All other research grants combined UK Charity grants UK Research Council grants EU govt Overseas Other EU other ISTM – Training Researchers • • • • Mentoring early-career lecturers and fellows Research fellows transition to independence ~35 research assistants and technical staff Support : eg Keele ACORN studentships, 3ME Initiative, MRC Centenary Awards, HEFCE Capital Equipment funds International links to ISTM • • • • • China, Malaysia, Brazil, India, Saudi Arabia Masters level PhD / MPhil Researcher exchanges Funded programmes – eg MRC African Leaders grant, HYANJI SCAFFOLD, NEMO, MagNETicFUN, Fellowships ISTM - Enterprise Activities • Industrial collaborations, eg: – MRC and BBSRC CASE studentships – European joint projects involving SMEs • Contract research with UK / European industry: – 3M Healthcare Abbott Laboratories AstraZeneca Biogen Bose Corporation - Enduratec Bristol Myers Squibb Cellon SA ConMed Cordis Endovascular GlaxoSmithKline GW Pharma Merck Sharp & Dohme Novartis Oxitec PepTcell Pfizer Smith & Nephew Surgicraft Syngenta Teva Weleda AG Wella AG Wyeth Research Zimmer • Licensing of IP • Spin off companies from ISTM: – NanoTherics Mica Biosystems Nuovoprobe ISTM web pages and contacts: www.keele.ac.uk/istm/ Director: Prof Alicia El Haj +44 (0)1782 554605 [email protected] RI Manager: Mark Smith +44 (0)1782 555234 [email protected] PA to Director: Paula Marsh +44 (0)1782 554253 [email protected] Facililties & Administration Manager: Jeanette Forrester +44 (0)1782 675380 [email protected]