Transcript EDCTP Activities

European HIV/AIDS programmes:
EDCTP as a model of Europe-Africa
partnership
19 July 2011
IAS 2011
Rome, Italy
Charles S Mgone
EDCTP Executive Director
About EDCTP
• Partnership between European member states,
European Commission and Africa in collaboration
with like minded organisations in fighting diseases of
poverty – HIV/AIDS, malaria and tuberculosis
• This is realised by funding clinical trials and research
capacity to accelerate development of intervention
tools including drugs, vaccines, microbicides and
diagnostics against these diseases
The partnership
EDCTP-EEIG member states
•
•
•
•
•
•
•
•
•
•
Austria
Belgium
Denmark
France
Germany
Greece
Ireland
Italy
Luxembourg
Netherlands
Norway
Portugal
Spain
• Sweden
• Switzerland
• United Kingdom
•
•
•
Sub-Saharan African countries
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Benin
• Malawi
Botswana
• Mali
Burkina Faso
• Mozambique
Cameroon
• Namibia
Congo
• Nigeria
Cote d’Ivoire
• Rwanda
Democratic Republic of Congo • Senegal
Ethiopia
• South Africa
Gabon
• Sudan
Ghana
• Tanzania
Guinea
• The Gambia
Guinea-Bissau
• Togo
Guinea-Conakry
• Uganda
Kenya
• Zambia
Liberia
• Zimbabwe
Madagascar
Strengthening of clinical trials
capacity and the enabling
environment
2
1
3
6
4
5
EDCTP Regional Networks
for Clinical Trials
Western Africa: WANETAM
Website: www.wanetam.org
Project Coordinator: Prof. Soleymane Mboup
•
•
•
•
Burkina Faso
The Gambia
Ghana
Guinea-Bissau
•Mali
• Nigeria
• Senegal
• United States
Central Africa: CANTAM
Website: www.cantam.org
Project Coordinator: Prof. Francine Ntoumi
• Cameroon
• Congo, Republic of the
• Gabon
• France
• Germany
Eastern Africa: EACCR
Website: www.eaccr.org
Project Coordinator: Dr Pontiano Kaleebu
•
•
•
•
•
Kenya
Sudan
Ethiopia
Tanzania
Uganda
•
•
•
•
Germany
Sweden
United Kingdom
United States
Southern Africa: TESA
Website: www.tesafrica.org
Project Coordinator: Dr Alexander Pym
•
•
•
•
•
Botswana
Malawi
Mozambique
South Africa
Zambia
•
•
•
•
•
Zimbabwe
France
Germany
Netherlands
United Kingdom
Funded projects including clinical
trials 2003-2011
EDCTP has funded 174 projects in 29 African countries
including 56 clinical trials on HIV/AIDS, malaria and TB
HIV/AIDS
26 clinical trials
108.30 M €
Tuberculosis
18 clinical trials
103.33 M €
Malaria
12 clinical trials
69.63 M €
• Treatments
• Vaccines
• Microbicides
13
9
4
• Treatments
• Vaccines
• Diagnostics
7
7
4
• Treatments
• Vaccines
10
2
HIV/AIDS treatment and
prevention trials
• Evaluation of paediatric formulations: fixed drug
combinations/scored dispersible tablets
• Evaluation of second-line treatment
• HIV/TB co-infections
• Prevention of Mother to Child Transmission of HIV
(PMTCT)
HIV preventive vaccine trials
• Capacity building in preparation for
HIV vaccine trials- Joint EDCTP/BMGF
grant
• DNA+MVA-CMDR (rgp 140/GLA-AF) phase I/II
clinical trial (TaMoVac + AfrEVacc) in healthy young
adults
• DNA + MVA-HIVA phase I/II in healthy infants born
to HIV1 and HIV2 uninfected and infected mothers
Microbicide trials
• Site preparation/capacity strengthening
• Establishment of cohorts
• Characterisation of novel safety markers
• PRO 2000 vaginal gel phase III clinical trial
EDCTP-II
• Consolidation of the current focus on clinical trials
• Phase II and III clinical trials
• Expansion to phase I and IV clinical trials
• Health services/optimisation studies
• Neglected Tropical Diseases including co-morbidities
• Open collaborative projects with other developing
countries beyond sub-Saharan Africa
Thank you
http://www.edctp.org