Transcript ICAAC 2011 K948

BSAC
Bacteraemia
Resistance Surveillance
Update 2013
Rosy Reynolds, Shazad Mushtaq, David Livermore
on behalf of
The BSAC Standing Committee on Resistance Surveillance
FIS, Harrogate, 24-26th Nov 2014
[email protected]
BSAC Resistance Surveillance Project
Bacteraemia
2012
Yearly targets (since 2010)*:
• 560 S. aureus, E. coli
• 280 CoNS, enterococci, S.
pneumoniae, other α/non-haemolytic
streptococci, β- streptococci;
Klebsiella, Enterobacter, Serratia,
Proteeae, Pseudomonas.
• Central laboratory testing
UK & Ireland
40 laboratories
(25 up to 2009)
PHE, London
• BSAC agar dilution MICs &
BSAC/EUCAST breakpoints.
(All 250 from 2001; E.coli & S. aureus 500 in 2008, 2009.)
www.bsacsurv.org
ACKNOWLEDGEMENTS
BSAC Bacteraemia Resistance Surveillance Programme
Central Laboratory
PHE Colindale
• Shazad Mushtaq
• David Livermore
... and many others
Collecting Laboratories
•
40, UK & Ireland – see
website
Sponsors 2009-2013
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Astellas
AstraZeneca
Basilea
Cempra
Cerexa / Forest
Cubist
J&J / Janssen-Cilag
Melinta (associate)
Novartis
Pfizer
Gram-positives
Methicillin-resistance in staphylococci 2001-13
Bacteraemia, UK and Ireland, N = 7325
100
90
80
70
60
50
40
30
20
10
BSAC Resistance
Surveillance Project
www.bsacsurv.org
S. aureus
CoNS
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
0
Methicillin-resistance in staphylococci 2009-13
Bacteraemia, UK and Ireland, N = 3605
100
90
80
70
60
50
40
30
20
10
BSAC Resistance
Surveillance Project
www.bsacsurv.org
S. aureus
CoNS
2013
2012
2011
2010
2009
0
Non-susceptibility in staphylococci 2013
Bacteraemia, UK and Ireland, N = 736
100
460 MSSA
62 MRSA
63 MSCoNS
151 MRCoNS
90
80
70
60
50
40
30
20
10
BSAC Resistance Surveillance Project
TET
ERY
CIP
TET
ERY
CIP
TET
ERY
CIP
TET
ERY
CIP
0
Non-susceptibility in staphylococci 2013
Bacteraemia, UK and Ireland, N = 736
522 S. aureus
30
214 CoNS
25
20
15
10
BSAC Resistance Surveillance Project
BPR
TGC
0
LZD
TEC
0
VAN
0
BPR
TGC
0
LZD
TEC
VAN
0
0
5
Species of enterococci 2001-13
Bacteraemia, UK and Ireland, N = 3042
BSAC Resistance
Surveillance Project
www.bsacsurv.org
E. faecium
other species
E. faecalis
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
100
90
80
70
60
50
40
30
20
10
0
Non-susceptibility in Enterococci 2013
Bacteraemia, UK and Ireland, N = 248
100
136 E. faecalis
112 E. faecium
90
80
70
60
50
40
30
20
TGC
0
LZD
TEC
VAN
GEN
IPM
AMP
0
TGC
LZD
0
BSAC Resistance Surveillance Project
TEC
VAN
GEN
0
IPM
AMP
0
0
10
Non-susceptibility in S. pneumoniae 2001-13
Bacteraemia, UK and Ireland, N = 2959
30
25
20
15
10
5
BSAC Resistance
Surveillance Project
www.bsacsurv.org
PEN-NS
FQ-R
ERY-R
MULTI-R
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
0
TET-R
Gram-negatives
Non-susceptibility in E. coli 2001-13
Bacteraemia, UK and Ireland, N = 4776
40
30
20
10
BSAC Resistance
Surveillance Project
www.bsacsurv.org
Ciprofloxacin
ESBL
Gentamicin
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
0
Non-susceptibility in E. coli 2009-13
Bacteraemia, UK and Ireland, N = 2581
40
30
20
10
BSAC Resistance
Surveillance Project
www.bsacsurv.org
Ciprofloxacin
ESBL
Gentamicin
2013
2012
2011
2010
2009
0
Non-susceptibility in Enterobacteriaceae 2013
539 E. coli
266 Klebsiella 207 Enterobacter
152 Serratia
246 Proteeae
BSAC Resistance Surveillance Project
N/A
N/A
CTX
TZP
IPM
CIP
GEN
CST
CTX
TZP
IPM 0
CIP
GEN
CST N/A
CTX
TZP
IPM
CIP
GEN
CST
CTX
TZP
IPM
CIP
GEN
CST
CTX
TZP
IPM 0
CIP
GEN
CST
0
5
10
15
20
25
30
Bacteraemia, UK and Ireland, N = 1410
Non-susceptibility in P. aeruginosa 2013
Bacteraemia, UK and Ireland, N = 233
20
15
10
5
N/A
N/A
C/T
BPR
0
0
CAZ
TZP
IPM
BSAC Resistance Surveillance Project
CIP
GEN
CST
SUMMARY
MRSA
Non-susceptibility in E. coli
Bacteraemia, UK and Ireland, N = 2528
Bacteraemia, UK and Ireland, N = 2581
40
30
30
MRSA
BSAC Resistance Surveillance Project
CIP
ERY
ESBL
BSAC Resistance Surveillance Project
CIP
2013
2009
2013
2012
0
2011
0
2010
10
2009
10
2012
20
2011
20
2010
Isolates, %
40
GEN
More data at…
www.bsacsurv.org
Non-susceptibility in Serratia 2001-13
Bacteraemia, UK and Ireland, N = 1382
BSAC Resistance
Surveillance Project
www.bsacsurv.org
Ciprofloxacin
cefotaxime
Gentamicin
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
100
90
80
70
60
50
40
30
20
10
0
Species of Proteeae 2001-13
Bacteraemia, UK and Ireland, N = 2840
BSAC Resistance
Surveillance Project
www.bsacsurv.org
M. morganii
other species
P. mirabilis
2013
2012
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001
100
90
80
70
60
50
40
30
20
10
0