Transcript BORDETELLA

BORDETELLA
K.V.PRAVEEN CHANDER
Important species
• Bordetella pertussis - Bordet-Gengou
bacillus
• Bordetella parapertussis
• Bordetlla bronchiseptica - ancestral form
• Bordetella avium
-causes
respiratory disease in turkeys
Virulence
Steele, R.W. Pertussis: Is Eradication Achievable. Pediatric Annals. Aug 2004. 33(8):525-534
Adhesions
• Filamentous hemagglutinin
• Pertactin
• Fimbriae
http://www.rivm.nl/infectieziektenbulletin/bul1306/kinkhoest.jpg
http://www.my-pharm.ac.jp/~yishibas/research/Pertussis1.jpg
Toxins
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Pertussis Toxin
Adenylate Cyclase Toxin
Tracheal cytotoxin
Dermonecrotic toxin
Heat-labile toxin
www.ibl.fr/u447/u447.htm
Pertactin
• Outer membrane protein antigen present
in all virulent strains
• Included in acellular pertussis vaccine
Bordetella parapertussis
• Infrequent, cause of whooping cough
• Disease is mild
• Pertussis vaccine do not give protection
Bordetella bronchiseptica
• Peritrichate flagella
• Antigenetically related to pertussis and
abortus
• Occurs naturally in the respiratory tract of
several sps of animals
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