Opportunities for Biomedical Computing and Informatics Research Funding at NIH

Zohara Cohen, PhD

Program Director NIBIB, NIH, DHHS

KOrean Computer Scientists and Engineers Association in America (KOCSEA) Technical Symposium

October 26, 2008

NIH Mission and Structure

NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability.

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NIA

NIH Structure

OD NIAAA NIAID NIAMS NIBIB NICHD NIDCD NIDCR NIDDK NIDA NIEHS NIGMS NIMH NINDS NINR NCI NEI NCCAM NCMHD NCRR NHGRI NHLBI CC CSR NLM FIC CIT

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NIBIB Mission

The mission of the National Institute of Biomedical Imaging and Bioengineering is to improve health by leading the development and accelerating the application of biomedical technologies. NIBIB is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care.

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

www.nibib.nih.gov

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Current NIBIB Portfolio Areas

• Biomaterials • Biomedical Informatics • Biosensors • Drug & Gene Delivery Systems • Image-Guided Interventions • Image Processing and Display • Magnetic Resonance Imaging and Spectroscopy • Mathematical Modeling, Simulation, and Analysis • Medical Devices and Implant Science • Micro-Biomechanics • Micro- and Nano-Systems; Platform Technologies • Molecular Imaging • Nanotechnology • Nuclear Medicine • Optical Imaging and Spectroscopy • Rehabilitation Engineering • Sensors • Surgical Tools, Techniques, and Systems • Telehealth • Tissue Engineering • Ultrasound: Diagnostic and Interventional • X-ray, Electron, and Ion Beam National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Biomedical Information Science and Technology Initiative (BISTI)

• established in May 2000 to serve as the focus of biomedical computing issues at the NIH • a consortium of representatives from each of the NIH institutes and centers • mission: – make optimal use of computer science and technology to address problems in biology and medicine – foster new basic understandings, collaborations, and transdisciplinary initiatives between the computational and biomedical sciences • coordinates research grants, training opportunities, and scientific symposia associated with biomedical computing

http://bisti.nih.gov/

BISTI FOA’s

• Innovations in Biomedical Computational Science and Technology (R01) - PAR-07-344 • Exploratory Innovations in Biomedical Computational Science and Technology (R21) - PAR-06-411 • Innovations in Biomedical Computational Science and Technology Initiative (SBIR [R43/R44]) - PAR-07-160 • Innovations in Biomedical Computational Science and Technology Initiative (STTR [R41/R42]) - PAR-07-161 • Continued Development and Maintenance of Software (R01) - PAR-08-010

http://bisti.nih.gov/

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

National Centers for Biomedical Computing (NCBCs)

• BISTI • Roadmap NCBC’s • Blueprint for Neuroscience • IMAG • CTSA Informatics Coordinating Committee • NanoHealth Enterprise • PhysioNet Resource • Osteoarthritis Initiative • caBIG Imaging Informatics Workspace

www.ncbcs.org

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NCBC Related FOA’s

• Collaborations with National Centers for Biomedical Computing (R01) - PAR-07-249 • Exploratory Collaborations with National Centers for Biomedical Computing (R21) - PAR-07-250 National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Interagency Modeling and Analysis Group

Multiscale Modeling

• spans scales from molecular to population • encompasses concepts of space, time and state space • expected to impact the understanding of biological processes • further the predictive capability in biomedical systems

Genes mRNA Proteins Lipids Carbohydrates Cell structure -function Tissue structure -function Organ structure -function Clinical medicine … 30,000+ genes 100,000+ proteins 200+ cell types 4 tissue types 12 organ systems 1 body

Courtesy of Peter Hunter

www.nibib.nih.gov/Research/MultiScaleModeling

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

IMAG Wiki http://www.imagwiki.org/mediawiki 10 Working Groups National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

• • • • • • • • • •

IMAG Multiscale Modeling (MSM) Consortium Working Groups

WG1 Filament Dynamics and Simulation (FDS) WG2 Cardiac and Skeletal Muscle Physiology WG3 Macro-To-Micro Scale Imaging and Transport in Human Systems WG4 Cell Level Modeling WG5 High Performance Computing, Computational Issues and Algorithms WG6 Tissue Mechanics WG7 Multiscale Imaging WG8 – Theoretical Methods WG9 – Nano-modeling WG10 – Model Sharing

Multiscale Modeling of the Physiome and the NIH vision for the 21st Century Grace C.Y. Peng, PhD April 10-11, 2008

International Physiome Symposium 2008 Toward Holistic Medicine: Physiome and Oriental Medicine Seoul, Korea

Please Populate Korea Page

Promoting Global Cooperation and Awareness

http://www.imagwiki.org/mediawiki National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

IMAG-Related FOA

12 NIH participating institutes 3 years, 9 receipt dates

PAR 08-023 Objectives

• To develop multiscale models that link at least two biological scales of modeling and accurately predict biomedical and behavioral processes in health and disease states • To develop predictive , multiscale models that link to higher levels of the physiome . Models must link to at least one scale beyond molecular interactions at the cellular level (e.g. to cell-cell, cell environment interactions, as listed above) • To develop predictive, multiscale models that are physiologically mechanistic and have translational potential or clinical applicability • To bring together modeling and biomedical expertise to collaborate on building multiscale model(s) • To validate and test models with standard datasets • To develop models that can be explicitly shared with other modelers

NIH Blueprint for Neuroscience Research

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Neuroimaging Tools and Resources Clearinghouse (NITRC)

Goal: Provide an independent clearinghouse for neuroimaging tools, vocabularies and datasets that promotes adoption and evolution of these resources by providing access, advice, and forums for input and discussion for both developers and the widespread user community.

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

www.nitrc.org

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

NITRC-Related FOAs

NIH Blueprint provides supplemental funding to support enhancement of existing neuroimaging informatics tools and resources to improve interoperability, adoptability, dissemination, and usability.

• Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination (R03) – PAR-07-417 • Notice of Availability of Administrative Supplements for Neuroimaging Informatics Software Enhancement for Improved Interoperability and Dissemination - NOT-EB 08-002 National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

BIRN: Biomedical Informatics Research Network

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BIRN and caBIG Related FOA’s

• Sharing Data and Tools: Federation using the BIRN and caBIG Infrastructures (R01) – PAR-07-426 • Data Ontologies for Biomedical Research (R01) – PAR-07-425 National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Biotechnology Resource Centers: a NCRR and NIBIB Program

Other Active NIH FOA’s with Relevance to Biomedical Computing and Informatics

• Bioengineering Research Partnerships (R01) - PAR-07-352 • Bioengineering Research Grants (R01) - PA-07-279 • NLM Express Research Grants in Biomedical Informatics (R01) - PAR-08-080 http://grants.nih.gov/grants/guide/ National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

Thank You!

Zohara Cohen

[email protected]

National Institute of Biomedical Imaging & Bioengineering, NIH, DHHS

The Future Paradigm: The 4 P’s

Transform Medicine from Curative to Preemptive

Predictive Personalized Preemptive Participatory