Transcript Document

UH
CogSci Projects for Spring 2005.
Inter- and Intra-Individual Gating
Differences.
Ben H.Jansen
Department of Electrical and Computer Engineering, and Center for NeuroEngineering and Cognitive Science, University of Houston, Texas
[email protected]
Collaborators: Nashaat N Boutros, MD, Dept. Psychiatry, Yale U;
Lingli Hu, Bharat Bonala, Karthik Sundaresan, Prashant Kota, Hitesh Doshi,
Vijay Grandhi, Gopal Agarwal, Ruben Jacob, Anant Hegde, Darshan Iyer,
Violet Garoosi
Supported by NIH/NIMH R01 MH58784, NSF/REU and UH-GEAR
Sensory Gating
P50
8
Gating: ability to
suppress irrelevant
stimuli
Double Stimulus
Paradigm:
P200
mV
6
S1
S2
4
2
0
-100
-2
-50
0
50
100
200
250
300
ms
-4
-6
150
stim
N100
– Two identical tone
bursts 0.5 s apart
– S1 response larger than
S2
Gating Deficits in Schizophrenia?
8
mV
6
4
S1
8
NC
SZ
6
mV
2
0
-100 -50
-2
0
-100 -50
-2
-4
-6
50
NC
SZ
4
2
0
S2
100 150 200 250 300
ms
-4
-6
0
50
100 150 200 250 300
ms
Paradigms and Data Set
•
•
•
•
S1
16 normal subjects, 17 schizophrenia patients.
Max. 4 sessions/subject
Cz-linked ears, Artifacts removed
Paradigms:
• Double Clicks:
8.0s
0.5s
• A: identical
S1 S2
S1 S 2
S1 S2
• B, C: non-identical
• Trains:
8.0s
/
•
F,
G:
S
=…=S
=S
1
5
6
S … S S
… S S
5
6
1
5
6
S1 and S2 Grand Average Amplitudes:
Paradigms
mV
A
B
C
F
G
NC
P200
N100
SZ
P50
S1
S2
S1
S2
S1
S2
Gating in Normal Controls
S1
S2
5
5
A
0
-5
0
100
200
300
400
F
0
100
200
300
400
200
300
400
48
56
83
71
60
51
56
53
63
47
48
90
56
58
500
0
100
200
300
400
500
5
G
0
0
100
200
300
400
0
-5
500
5
0
100
200
300
400
500
5
B
0
0
100
200
300
400
0
-5
500
5
0
100
200
300
400
500
5
C
0
-5
100
0
-5
500
5
-5
0
65
5
0
-5
0
-5
500
5
-5
P50 N100 P200
0
100
200
300
400
500
75
0
-5
83
0
100
200
300
400
500
56
55
58
58
Gating in Schizophrenia
S1
S2
5
5
A
0
-5
5
0
100
200
300
400
5
F
0
100
200
300
400
G
0
100
200
300
400
200
300
400
0
100
200
300
591
62
57
831
74
72
69
73
127
82
90
80
72
73
91
85
80
102
99
87
500
400
500
0
-5
500
5
0
100
200
300
400
500
5
B
0
0
100
200
300
400
0
-5
500
5
0
100
200
300
400
500
5
C
0
-5
100
64
5
0
-5
0
0
-5
500
5
-5
0
-5
500
0
-5
P50 N100 P200
0
100
200
300
400
500
0
-5
0
100
200
300
400
500
1Red
means greater than NC
AUDITORY P300
Bharat Bonala, Prashant Kota, Karthik Sunderasan, Nashaat N
Boutros, and Ben H Jansen
Differences between normal and
schizophrenia subjects.
Brain-Machine Interface.
P300 and the Odd-Ball Paradigm
2 sec
F F F R F F R F R F
F Frequent/Non-Target stimulus
R Rare/Target stimulus
P300: response to a relevant, infrequently
occurring stimulus.
Normal Controls have larger P300 than
Schizophrenia Patients
Using the BMI
A
B
C
D
E
F
G
H
I
J
K
L
HUNGRY
M
N
O
P
Q
R
THIRSTY
LIGHT ON
S
T
U
V
W
X
LIGHT OFF
Y
Z
1
2
3
4
5
6
7
8
9
--
Spelling Machine
Donchin et al, IEEE-T-BME, 2000