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ALLTECH 37+™ Survey : North American Corn Harvest 2014 Dr. Max F. Hawkins & Dr. Alexandra Weaver Alltech’s Mycotoxin Management Team Main molds and mycotoxins Field Origin Storage Origin Fusarium Aspergillus Penicillium Deoxynivalenol Zearalenone T-2 Toxin Fumonisin Moniliformin Nivalenol Fusaric Acid Aflatoxin Ochratoxin Sterigmatocystin Fumitremorgens Fumigaclavines Fumitoxins Gliotoxin Ochratoxin PR Toxin Patulin Penicillic Acid Citrinin Penitrem Cyclopiazonic acid Mycotoxins – What are they ? Compounds produced by certain mold species • • • • 400+ Invisible Stable Toxic effects Why do mycotoxins flourish? • Agronomy • Climate: Rainfall, temperature • Plant stress: Disease, insects, birds, weather damage Analytical Services Lab of Alltech Published method Broad spectrum of feed materials 37+ mycotoxins, simultaneous analysis DON-3-Glucose Fusaric Acid Storage – Penicillium and Aspergillus Providing risk assessment Sample type Corn Silage Mold Mycotoxins Concentration (ppb) Aspergillus Aflatoxins Bl l Total Aflatoxins n Och1atoxins 5 6 OrllerAspergillus To\ins Fusarium Trichothecenes B 1,750 Trichothecenes A 614 Futnonisins 1,390 Zearalenones 1,457 Penicillium & Misc. Penicillium Toxins 307 Pythomyces Ergot Alkaloids 683 37+ Mycotoxin Risk Assessme nt Aflat oxins B l . ·- J Tot al Aflatoxins Ochratoxins Ot her Aspe r gillus Toxins :::J _"::J Trichoth ece nes B - Trichoth e ce nesA "I Fumonisins Zearalenone s ] Pen icillium Toxins Ergot Alkaloids =:J . Risk equivalent quantity (REQ) WHAT IS THE REQ? •An evaluation of the total toxicity of a given mycotoxin mixture based on the amount of individual mycotoxins in reference to Aflatoxin Bl REQtotal =ctox 1 X REF tox 1 + ctox 2 X REF tox 2 + ...+ ctox n X Myco t oxin Risk Assessment caution Advised Low Risk High Risk Aflatoxin (Bl ) ::::::=:::::.=.J Afl atoxi ns(Bl B2+Gl 2 ) Ochratoxins (A-B) Type B - richothecenes• Type ATrichotrecenes · Fumonisins(Bl+B2 B3) .llllliiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii ====== ZearalenoneGr0\4) Fusari cAci d Otl'er Penid Ui\Sn Mycaoxirli· · · Other Aspergillus Mycaoxirli" • • • Ergot >oxi ns REQ(RiskEquival entQuantity) i!!!!i! :::::::;:::::::::= = = : = : ;==ii!!!!!!!!!!!!!!!!!!ll REF tox n North American Corn 2014 North American Corn 2014: Risk to Layers and Breeders Low Medium High What do mycotoxins cost layer producers? Change from Control, % 80 60 40 20 0 0 1000 2000 3000 4000 5000 -20 -40 -60 ↓1.7 eggs/wk REQ, ppb Total Eggs Produced FCR ↑0.38 FCR ↓$0.14/hen/wk What could you save with ALLTECH MYCOTOXIN MANAGEMENT? Layers Addition of MYCOSORB to mycotoxin treatments +1.4 eggs/wk -0.09 FCR Net return improved $0.11/hen/wk (Product cost of $0.006/bird/wk) ROI 2.46:1 2014 North American Corn Percent of 2014 Corn at Low, Medium, or High Risk REQ to Broilers Highest Risk REQ = 859 High Risk REQ ≥ 100 Estimated ADG Loss -5.26% Low 48.9% Medium 33.3% Moderate Risk REQ = 75 Estimated ADG Loss -5.18% Estimated ADG Loss -7.58% High 17.8% Low Risk REQ ≤ 35 Estimated ADG Loss -5.06% Summary Risk assessment • Opportunity to link mycotoxin risk to animal performance through use of ALLTECH 37+ REQ • Provides a holistic approach for analysis, reporting, and controlling multiple mycotoxin contamination as well as understanding the impacts of mycotoxins on animals Your flock is your business. Protecting it is ours.