Transcript Document

Your first mentored grant proposal:
The National Institutes of Health
F and K proposals
Alison K. Hall, Ph.D.
Case School of Medicine
Office of Graduate Education
Committee on National Needs for Biomedical and
Behavioral Scientists, a unit of the National
Research Council, the operating arm of the National
Academy of Sciences.
Estimates that there are some 52,000 postdocs in
the country (2001)
3/4 in life sciences, half from foreign countries
Postdoctoral trainess at Case SOM, Spring 2005
Total SOM
Male
Female
Postdoc
Scholar
30
18
12
Postdoc
Fellow
81
48
33
Research
Associate*
277
160
117
Senior
Research
Associate*
57
33
24
Many are planning independent careers
Postdocs are at a critical juncture in training
productive
self-reliant
about to embark on independent careers
Often write a grant to seek financial support and
recognition for their research
Why do you want a mentored grant?
1. Makes the relationship with the PI explicit
2. Benefits associated with grant
3. Looks good on your resume
4. Great learning experience
5. Not ready for the R01…
Where do you start?
Communicate
your PI, potential mentors/committee
your chairperson
the Office of Research
Are you ready?
pilot data
time to focus
appointment status
deadlines
Do you qualify?
Not every Institute has these mechanisms
Restricted to US citizens, permanent residents
The F32 NRSA
individuals seeking posdoctoral research training
in the basic and clinical sciences
F32->RO1
set stipend scale and supplement
The F32 NRSA
February 4, 2005
Stipends for Kirschstein-NRSA awards 2005
Postdoctoral
Years of Experience:
0
$ 35,568
1
$ 37,476
2
$ 41,796
3
$ 43,428
4
$ 45,048
5
$ 46,992
6
$ 48,852
7 or more
$ 51,036
Program announcements
http://grants.nih.gov/training/nrsa.htm
Institutional Allowance $5,500 Research supplies,
health insurance, travel to mtgs
The F32 NRSA is a reasonable goal:
Success rates on Individual Postdoc Fellowship applications
2002 Number
reviewed
MD 202
PHD 1,336
all
1,538
number
awarded
total cost
success
awarded 1000s rate*
91
516
607
4,602
20,813
25,415
45
38.6
39.5
Percentage that receive funding in a year
(a resubmission is only counted the first time)
http://grants.nih.gov/grants/award/training/F32MDPHD9502.HTM
Prepare the Application: read the instructions!!
start early, seek internal reviewers
a. Candidate (grades, GREs, etc)
a. US citizen or permanent resident
b. Doctoral degree (many ok)
b. Sponsor and Training Environment
c. Research Proposal
a. Up to 3 yrs
c. Training Potential
d. Vertebrate Animals, Human Subjects etc.
e. 3 times per year, usu Feb1, June1, Oct 1
The A1 or A2. You may have to resubmit…
http://grants.nih.gov/training/nrsa.htm
The F32 NRSA success is about 30%
http://grants.nih.gov/training/data/tf_trends/sld006.htm
Postdoctoral trainees are funded by many Institutes
http://grants.nih.gov/training/data/tf_trends/sld006.htm
Case has few F awards
Predoctoral (Graduate Students!)
1F30NS050913-01
5F30ES011931-03
1F31HD049326-01
1F31MH073296-01
1F31NR009344-01
5F31HD041926-03
1F31MH074241-01
5F31NR007943-04
Assistive Device Control With Brain Surface Signals
Initiation of Experimental Colitis by Commensal Flora
Upper Extremity Control Using Reinforcement Learning
Molecular Genetics of the Serotonin System
Dance and Physical Activity in African American Women
PREDOCTORAL FELLOWSHIP FOR STUDENTS WITH DISABILITIES
ERK2 Specific Function of the CNS
Kangaroo Care Effects on post/cath stabilization
1F32GM074554-01 Creation of designer biogenic amine receptors
1F32AG024031-01A1 Mechanisms of Abeta-Stimulated ROS in Microglia
5F32EB003363-02 Group Theory Applied to rf Coil Design
Postdoctoral
http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen
Grantwriting Resources
Grantpersonship: An Instruction Manual
http://www.pitt.edu/~survival
NIMH Grant Application Process
http://www.nimh.nih.gov/researchFunding/grantprocess.cfm
http://www.nimh.nih.gov/researchFunding/training.cfm
FASEB Grantsmanship Training Program
https://ns2.faseb.org/careerutilities/grantprg.htm
Grant Application Writer’s Handbook, Reif-Lehrer
The K08
For clinically trained persons to pursue research careers
in basic or clinical sciences.
Must apply within 3 years of clinical
Training (residency +1 year of clinical fellowship)
Mentored Clinical Scientist Development Award
K08->K02-> R01
up to $85,000 salary up to $50,000 costs per year
up to five years, non-renewable
The K08
Prepare the Application: read the instructions!!
a.
b.
c.
d.
e.
f.
g.
h.
Candidate
Research Plan
Career Development Plan/ Training Plan
Environment/ Institutional support
Mentor*
Vertebrate Animals, Human Subjects etc.
The A1 or A2. You may have to resubmit…
(The summary statement)
The K08
1. Candidate**
2. Basic Science Mentor/co Mentor:
1. Good working relationship
2. Often funded by NIH
3. Expert in this area
4. Experienced trainer
**some Institutes require faculty appointment (eg Instructor)
The K08
3. Career Development Plan (very important)
•
Focused and relevant
•
New techniques, new area, could be funded
•
Present at meetings, review grants, external
courses
•
Update didactics
•
Create an oversight committee familiar with
research, career goals, meet six mos for feedback
4. Research Plan
•
Provide preliminary data to support rationale,
approach. Focus!
•
Include study of Research Ethics, animals etc.
The K08
http://grants.nih.gov/grants/guide/pa-files
See supplementary info at each institute
Insure protected time
-Do not assume that 75% means anything
except 75% of your total working hours
-These estimates are carefully reviewed
essential that your chair state this
not contingent on receipt of the grant
-50% Neurosurgery
What happens to your application after it leaves the mailbox?
Scientific Review Group in Center for Scientific Review
Study section review
supplements
Scores and percentiles
Summary sheet
Inside the NIH Grant Review Process
39 min video NIH Center for Scientific Review
Includes R01/K08/ R03
Download proposals
http://www.drg.nih.gov/Video/video.asp#docs
View the video on the web
http://www.drg.nih.gov/Video/Video.asp
Helpful Hints for an NLHBI K08 Application
http://www.nhlbi.nih.gov/funding/training/redbook/hints.htm
K08 awards at Case
1K08HL073240-01A1Medullary GABAergic Neurons in Neonatal Reflex Apnea
5K08AI001581-05
CD8+ T CELLS AND MYCOPLASMA TUBERCULOSIS
5K08CA084337-06 ERBB2 KINASE SIGNALING IN COLON CARCINOGENESIS
5K08DK059488-04 The Role of TGF-alpha in the Pathogenesis of ARPKD
5K08DK002699-05 QUANTITATIVE EXPRESSION LIBRARIES TO IDENTIFY ESRD GENES
5K08MH068584-02 Youth Subjective Experience of Psychotropic Treatment
5K08HL004299-05 PULMONARY IMMUNE DEFENCES AGAINST M. BOVIS-BCG INFECTION
5K08AI054652-02
Innate immune responses in lymphatic filariasis
1K08HD047431-01 Metabolic Requirements for Oogenesis and Embryogenesis
5K08AI051565-03
Immunologic Studies of Endemic Burkitt's Lymphoma
5K08NS046486-02 Systemic perinatal insults disrupt neurodevelopment
5K08NS041594-03 The Role of PPAR Agonists in Inflammation and stroke
http://crisp.cit.nih.gov/crisp/crisp_query.generate_screen