Transcript Granulation - Queen's University
Granulation
Is done to: improve flow properties of the mix improve compression properties of the mix prevent segregation of components in powder mix reduce production of toxic dust reduce possibility of ‘cake’ formation increase convenience of transport CHEE 440 1 B. Amsden
Wet Granulation
particle bonding mechanisms adhesion and cohesion forces in immobile liquid films interfacial forces in mobile liquid films B. Amsden solid bridges attractive forces between solid particles CHEE 440 2
Wet Granulation
Wet granulation equipment: high shear granulator B. Amsden CHEE 440 3
Wet Granulation
low shear granulator
Wet Granulation
fluidized bed granulator V M g p 150 M 3 1 M s 2 D p 2 u t V M M s 2 3 M B. Amsden CHEE 440 5
Wet Granulation
spray granulation D s r 0.4
L nr 2 0.6
0.2
L L p 2 0.1
B. Amsden CHEE 440 6
Wet Granulation
pelletizers B. Amsden CHEE 440 7
Dry Granulation
B. Amsden CHEE 440 8