Granulation

Is done to:       improve flow properties of the mix improve compression properties of the mix prevent segregation of components in powder mix reduce production of toxic dust reduce possibility of ‘cake’ formation increase convenience of transport CHEE 440 1 B. Amsden

Wet Granulation

particle bonding mechanisms  adhesion and cohesion forces in immobile liquid films  interfacial forces in mobile liquid films B. Amsden  solid bridges  attractive forces between solid particles CHEE 440 2

Wet Granulation

Wet granulation equipment:  high shear granulator B. Amsden CHEE 440 3

Wet Granulation

 low shear granulator

Wet Granulation

fluidized bed granulator V M  g   p    150   M 3 1   M  s 2 D p 2 u t V M     M  s 2  3 M  B. Amsden CHEE 440 5

Wet Granulation

 spray granulation D s r  0.4

    L nr 2  0.6

       0.2

   L L p  2   0.1

B. Amsden CHEE 440 6

Wet Granulation

 pelletizers B. Amsden CHEE 440 7

Dry Granulation

B. Amsden CHEE 440 8