Transcript Device to Improve Diagnostic Yield of Fine Needle

Device to Improve
Diagnostic Yield of Fine
Needle Aspiration
Client: Dr. Frederick Kelcz
Advisor: Professor Naomi Chesler
Team Members:
Jason Tham
Chou Mai
Robyn Hrobsky
Aaron Freis
Fine Needle Aspiration
(FNA)


Biopsy method
Performed in:





Lymph Nodes
Neck Cysts
Thyroid Gland
Breast Tissue
Types of Samples:



Malignant
Benign
Test Inconclusive
FNA Procedure





Small needle inserted into
tissue mass
Mass isolated by hand
Needle moved in and out
Sample examined for
abnormal cells
Multiple procedure passes
typical
Problem Statement

Improve FNA procedure:



Devise:



Single timely procedure
Maximize sample yield
Automated needle oscillation device
Automated vacuum mechanism
Test on:


Phantom tissue
Human tissue in clinical setting
Design Constraints

Test Variables
Needle oscillation frequency (0 – 10 Hz)
 Needle stroke length (5 – 20 mm)


Performance Requirements
Reusable and repeatable
 Easily sanitized between procedures
 Handheld size


Safety Standards
Previous Achievement
Motor-wheel model
 Vacuum by hand
 Yielded sample size of
0.63mm3
 Maximum Frequency: 7Hz

Prototype Complications




Gear grinding
Difficulty adjusting stroke
depth
Inertial vibration
Poor repeatability
Design 1: Improved Motor
and Wheel
Improve alignment of
mechanical components
 Implement ABS plastic
encasement
 Implement Delrin plastic
bearings

Design 1: Pro’s and Con’s






Pro’s
Common components
Internal power source
Never been patented
Con’s
Force inconsistency
Vibration
Motion not entirely linear
Design 2: Pneumatic Device
Pneumatic
Implementation
Control Components
Gas Pressure
(0-30 PSI)
Signal Control
Flow
Signal
Dell Latitude
Signal
Op Amp
Pneumatic Valves
Flow
-Valve Control VI
Software
-LabJack Interface
-Signal Amp or
Mosfet / Relay
Device Actuator
Design 2: Pro’s and Con’s
Pros
 Frequency is exact
 Needle stroke easily adjusted
 Ergonomics, acoustics and fluidity
 Consistent needle force
Cons
 Tubes and cords
 Limited to square wave drive
Design 3:Conceptual
Designs

Sonic Scaler
Dentistry
 Air-powered
 Vibration at 6000 Hz


Vibration Motor
Linear force ≈ .46 - .80 N
 Weight less than a gram
 Radius ≈ 4 mm

Vibration motors
Design Matrix
Feature
(possible points)
Improved Motor
and Wheel
Pneumatic
Safety (Essential)
Yes
Yes
Ergonomics (10)
2
7
Durability (10)
5
7
Repeatability (22)
14
17
Frequency Adjustability (22)
16
20
Stroke Adjustability (22)
10
15
Patient Comfort (10)
5
6
Cost (4)
4
4
56
76
TOTAL (100)
Competition

Cameco Syringe Pistol

Tao Aspirator



Close hand-to-needle distance
Automatic plunger withdrawal
No drive mechanism
Future Work

Construct pneumatic prototype


Test on animal and human tissues
Clinical trial
Develop automated vacuum system
 Research conceptual improvements
 Patent design ideas

Reference











BME Website. <http://homepages.cae.wisc.edu/~bme200/> March 6, 2007
Breast Cancer Awareness. <http://rinnavahk.ee/> March 5, 2007
Breast eNotes < http://health.enotes.com/images/> March 6, 2007
Chris Goplen. Solid Works Model of Wheel and Motor design. 12/2006.
Designs and Technology. <http://www.technologystudent.com/> March 3, 2007
Fine Needle Aspiration Biopsy of the Thyroid Gland. 2005 Mayo Foundation.
<http://www.thyroidmanager.org/FunctionTests/fnabiopsy-text.htm> March 5, 2007.
Minebea-Matsushita Motor Corporation [ VIBRATION MOTOR FEATURES ]. 2007
Minebea-Matsushita Motor Corporation. <http://www.m-mmotor.com> March 5,
2007.
Pneutronics-Miniature Fluidic Control. < http://www.parker.com/> March 3, 2007
Sergei Egorov’s Lego Page. <http://www.malgil.com/esl/lego/> March 2, 2007
Sonic Scalers and Air Scalers from Lone Star Dental Corp. Lone Star Dental
Corporation. <http://www.dentequip.com/Equipment/Scalers/index.htm> March 5,
2007.
Tao Aspirator. 2001 Tao & Tao Technology, Inc. <http://www.taoaspirator.com/>
March 5, 2007.