Transcript Hemodynamic disorders p.1

Cell injury p.2 and cell death
SYLLABUS:
Robbins and Cotran, Pathologic Basis of
Disease, Chapter:
Cellular Responses to Stress and Toxic
Insults: Adaptation, Injury, and Death
excluding:
hypertrophy
hyperplasia
metaplasia
Cell injury p.2 and cell death
28
39
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43
s/35
30
Kidney amyloidosis
Caseous necrosis (tuberculosis, lymph node)
Liquefactive necrosis (peptic ulcer)
Balser necrosis (enzymatic fat necrosis)
Epidermal cyst
Leukokeratosis (oral mucosa sample)
Kidney amyloidosis
-amyloid deposits in glomeruli and in the walls
of blood vessels
(metachromatic stain)
Kidney amyloidosis
Kidney amyloidosis
Caseous necrosis (tuberculosis, lymph node)
-area of necrosis:
- amorphous, granular, pink debris with no
visible nuclei or cell contours
-elements of TB granuloma:
-giant Langhans cells
-epithelioid cells
-lymphocytes
-lymph node structure
Caseous necrosis (tuberculosis, lymph node)
Caseous necrosis (tuberculosis, lymph node)
Caseous necrosis (tuberculosis, lymph node)
Liquefactive necrosis (peptic ulcer)
-defect (excavation) caused by the necrosis of
the previously pathologically altered tissue
-thin layer of necrotic tissue debris
-underlying inflammatory infiltration
Liquefactive necrosis (peptic ulcer)
Liquefactive necrosis (peptic ulcer)
Balser necrosis (enzymatic fat necrosis)
-shadowy outlines of necrotic fat cells
-basophilic deposits replacing fat in cells
-surrounding inflammatory infiltration
Balser necrosis (enzymatic fat necrosis)
Balser necrosis (enzymatic fat necrosis)
Epidermal cyst
-normotypical (sometimes flattened) squamous
epithelium lining the cyst
-keratin masses filling the cyst
Epidermal cyst
Epidermal cyst
Leukokeratosis (oral mucosa sample)
-keratinizing squamous epithelium (with
granular and keratinized layer)
(no skin appendages visible)
(.ppt demonstration only, no slides during the
microscopy lab)
Leukokeratosis (oral mucosa sample)
Leukokeratosis (oral mucosa sample)