Transcript Occupational Disorders Flip - Robert Wood Johnson Medical
Occupational Disorders Flip JK Amorosa
References
• Cox, W et al: State of the Art: Imaging of Occupational Lung Disease radiology 2014; 270: 681-696
• • • • • • • • •
Pneumoconiosis beyond A and S
A sbestosis
A rdystil Syndrome B yssinosis C oal Workers Pneumoconiosis F lockworkers lung HMLD (Hard Metal Lung Disease) ITO (Indium-tin-oxide)
S ilicosis
S iderosis
Asbestos: mineral
Composition:
Silicon Oxygen Hydrogen Calcium Sodium Metals: magnesium, iron
Characteristics:
Strength Flexibility Low electrical conductivity Resistant to heat and chemicals Greek origin means: inextinguishable, or indestructible
Asbestos
• • • fibrous mineral construction materials: roofing, siding shingles, pipe and boiler insulation, floor/ ceiling tiles carcinogen years following asbestos exposure
Asbestos
• undisturbed asbestos-containing materials: no
health risk
• damaged or disturbed, or deteriorate over time and release asbestos fibers into building air: health risk
Byssinosis (brown lung)
• Exposure to dust from cotton, hemp and flax • • Causes blockage of small airways ?? Endotoxin release from cell walls of Gm bacteria
Flockworkers lung disease
• • At Microfibres Inc in Rhode Island two young men developed interstitial lung disease Plant made carpet-like material for car upholstery. Workers cut long nylon strands into short nylon fibers called flock. The fragments were in the respirable size and were inhaled by the workers
Hard Metal Lung Disease(HMLD), also called Giant cell Interstitial Pneumonia (GIP) • • Characterized by “cannibalistic” multinucleated giant cells in airspaces on BAL Powdered tungsten carbide and cobalt • Called sintered carbides, hard as diamond
ITO Indium tin oxide
• Transparent , colorless, when deposited as a thin film on glass, it acts as an electrical conductor • Used for display technology: LCD, plasma, electroluminescent, touch screen technology
• • • Iron ore miners Welders Steel workers
Siderosis
• • • Fibrosis Obstructive airway disease Lung ca
Localized malignant mesothelioma (stage I)
• Unilateral parietal or visceral pleura and pericardium
Advanced malignant mesothelioma (stage II,stage III, and stage IV)
• • • • stage II, cancer in ipsilateral pleura, pericardium In stage III, cancer has spread to any of the following areas: – The chest wall. – The mediastinum. – The heart. – – Beyond the diaphragm. The peritoneum. Cancer may have also spread to lymph nodes on the other side of the chest or outside the chest.
In stage IV, cancer has spread to distant organs or tissues.
WHO
• • 200,000 people die each year from cancers related to their workplaces, mainly from inhaling asbestos fibers and second-hand tobacco smoke.
125 million people worldwide are exposed to asbestos at work and every 10th lung cancer death is related to occupational hazards, which amount to at least 90,000 deaths each year.
P N E U M O C O N I O S I S
• LUNG DUST
Occupational Lung Diseases
• Occupational lung diseases are caused by inhaled particles,mists, vapors or gases while at work.
Occupations
Miners Millers Cement workers Construction Demolition Railroad workers Pipe fitters Shipyard workers Fertilizer manufacturers Brake repair Pharmaceuticals Diesel exhaust Fire fighters Aircraft workers Plastics Explosives Fuels Welders Paint Bleach Chrome plating Paper industry Oil/ Petroleum Chemistry Dye Farmers Sewer cleaners Roofers Steel workers Ceramics Sanders Polishers Boiler makers Textiles Floor tilers Pigments Refinery workers Electronics Bricklayers US Navy Atomic energy Rubber
Asbestos Exposure
in 3000 commercial products 1940 - 1979 US 27 million people occupational exposure to asbestos 7% were engaged in primary mining, milling, and manufacturing of asbestos products
Asbestos Related Pleural Disease
1. Plaque 2. Pleural effusion, benign 3. Rounded atelectasis****** 4. Mesothelioma
Asbestos Related Lung Disease: Asbestosis
• Asbestosis is the term reserved for pulmonary fibrosis caused by the inhalation of asbestos fibers. Subpleural lower lobes areas - mostly • Malignant masses: lung ca • Benign mass: rounded atelectasis, pleural thickening, mass contains low density centrally, has comet tail containing crowded vessels and bronchi
Pattern
• Silicosis- upper lung nodules • Asbestosis -lower lung linear opacities
Etiologies of Interstitial Pulmonary fibrosis include
1. Scleroderma 2. Idiopathic 3. Asbestosis 4. Silicosis
Asbestosis • HRCT: Septal and centrilobular thickening, long scars, parenchymal bands, subpleural lines, honeycombing • Radiograph: lower and mid lung zone reticulo-nodular process, causing “ shaggy ” heart border, honeycomb
• • •
Development of lung disease is dependent on
Intensity of exposure Duration of exposure Physiologic and biologic susceptibility of host
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Acute
Inflammation Edema
Reactions
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Chronic
Fibrosis Granuloma
Pneumoconiosis - most common
• • • • • Asbestosis Berylliosis Byssinosis CWP (Coal Workers Pneumoconiosis) Silicosis
Kun –Kim et al November 2001 RadioGraphics, 21, 1371-1391.
Silicosis
Small well-defined nodules of 2 to 5mm in diameter in both lungs Upper lobe predominance Nodules may be calcified Centrilobular and subpleural distribution Sometimes random distribution Irregular conglomerate masses, known as progressive massive fibrosis Often hilar and mediastinal lymphnodes.
Chart illustrates the descriptors from the 7th edition of the TNM staging system for lung cancer.
UyBico S J et al. Radiographics 2010;30:1163-1181
©2010 by Radiological Society of North America