Transcript Health Effects of Pesticides on the Neurological System

Health Effects of Pesticides
on the Nervous System
Helen Murphy – FNP, MHS
Pacific Northwest Agricultural Safety and Health Center (PNASH)
School of Public Health
University of Washington
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Central and Peripheral Nervous System:
Pesticide Induced Signs and Symptoms
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Paresthesias
Headache
Behavioral-mood
disturbances
Depression/stupor/
coma/respiratory failure
Seizures
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Muscle twitching
Tetany, carpopedal spasms
Tremor
Incoordination/ataxia
Paresis, muscle weakness
Hypotensive shock
Hypertension
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Paresthesias
Facial - transitory
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Pyrethroids- cyno group
(I) – facial
Organophosphates (I)
Organochlorines (I)
Phosphides (R)
Thiobendazole (Asc)
Nicotine (late)
Extremities
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Inorganic arsenicals (I)
Organic mercury (F)
Sodium fluoroacetate (R)
Carbon disulfide (Fum)
Thallium – painful (R)
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Headache
a common health outcome of pesticide exposure
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OP-Carbamates (I)
Nicotine (I)
Metallic compounds (F):
mercury, cadmium,
copper, organotin
Thallium (R)
Fluoride (I)
Borates (I)
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Naphthalene (moth balls)
Phosphine (Fum)
Halocarbon fumigants
Creosote (wood
preservative)
Diquat (H)
Cholecalciferol (R)
Cyanamid (Fum)
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Behavioral-mood Disturbances
confusion, excitement, mania, disorientation, emotional liability
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Organic mercury (F)
Inorganic arsenicals (F)
Organotin cmpds (F)
Thallium (R)
Nicotine (I)
Sodium fluoroacetate (R)
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Diquat (H)
Cyanide (Fum)
Nitrophenols (H)
Aminopyridine (bird bait)
Methylbromide (Soil
fumigant - potatoes)
Carbon disulfide (Fum)
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Depression, Stupor, Coma,
Respiratory Failure without convulsions
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Op’s
Carbamates
Sodium Fluoride (Fum)
Borate
Diquat
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Seizures
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Organochlorines (I)
Strychnine – (R)
Crimidine – (R)
Sodium fluoroacetate (R)
Nicotine (I)
Cyamide – (R)
Acrylonitrile (Fum)
Metaldehyde –(slug bait)
Thallium – (R)
DEET (repellent)
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Chlorobenzilate (Asc)
Carbon disulfide (Fum)
Phosphine (Fum)
Povidone-iodine (D)
Hexachlorophene (D)
Sodium chlorate (H)
Endothall (H)
Fluoride (I)
R=Rodenticide I=Insecticide D=Disinfectant Asc=Ascaride Fum=Fumigant
H=Herbicide F=fungicide
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Involuntary Muscle Movements
Fasciculations
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OP’s
Carbamates
Nicotine
Sulfuryl fluoride (Fum)
Tremors
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Organic mercury
Thallium
OPs
Carbamates
Nicotine
Metaldehyde (slug bait)
Borates (roach and ant
control)
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Incoordination & Muscle Weakness
Ataxia – Incoordination
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Halocarbon fumigants
Ops
Carbamates
Carbon disulfide
Nicotine
Thallium
Paralysis/Paresis
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Inorganic arsenicals
OP’s
Carbamates
Nicotine
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010
Neurological Effects on the
Circulatory System
Hypertension
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Thallium (early)
Nicotine (early)
OP’s
Hypotensive Shock
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Phosphorus
Phosphides
Phosphine
Sodium fluoride
Sodium chlorate
Borate
Thallium
Endothall
Cyanamide
Pesticide Health Effects Medical Education Database (PHEMED)
Murphy 2010