Transcript Evidence Based Primary Care

Practice of Evidence-Based
Medicine
9th April 2001
Dr Martin Dawes
University of Oxford
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Who am I?
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General Practitioner for 17 years
Worked in a town practice 5 partners
Started research in 1985
Investigating hypertension
Director Centre Evidence-Based Medicine
Wife is a physiotherapist
2 children aged 19 & 17
Contents
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Why EBM?
What is EBM?
Clinical problem exercise
Knowledge
CAT’s
15 seconds to FAQ’s
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Increasing Medical Knowledge
• 27Kg of Guidelines
• New papers per day
– 3,000
• Medline New articles
– 1,000
• RCT’s
– 46
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Increasing Knowledge
Number of articles on Hypertension cited in
Medline by Year
8000
6000
4000
Articles
2000
0
1966
1976
1986
1996
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How Much Do We Read in Clinical
Practice?
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1/2 hour or less/week:
1 hour:
1 1/2 hours:
2 hours:
3 hours or more:
3%
46%*
23%
20%
8%
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Where do we get knowledge?
• Print Source:
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General/speciality textbooks
Pharmaceutical textbooks
Journals
Drug Company Information
Self Made Compendia
• Human Sources
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Reported
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Observed
%
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Gorman P et al. Bull Med Libr Assoc 1994; 82(2): 140-6
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Educational Strategy
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Talks by experts not GP’s
Subjects are chosen by others
Usually relate to secondary care
Often about topics we feel comfortable with
Usually large lectures
Very little follow up
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How many do we see
• 100 - 200 consultations a week
• 5,000 -10,000 per year
• It is difficult to be sure that one is doing the
right thing for all these cases.
• One relies on experience
• Use 2 million pieces of information - stored
in your memory
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Aren’t we doing OK anyway?
• in 1994 17% of family Practitioners thought
that aspirin had no effect on the survival of
patients having an MI (evidence 1988)
• Variation in prescribing, diagnostic tests,
supervision of chronic conditions
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Why Evidence Based Health Care?
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Too many patients
Too many problems
Too many journals
Information overload
No time to read
Read what I am familiar with
Avoid difficult issues
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What is Evidence-Based
Medicine?
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See a patient
Ask a question
Seek the best evidence for that question
Appraise that evidence
Apply the evidence
Monitor the change
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Structured Question - Why Bother?
• What do you think about ACE inhibitors
and heart disease
• You know about EBHC - can you look it
up?
• ACE & Heart Disease 2,755 articles on
Medline through PubMed
• Need structure to my question
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Foreground
Questions
Background
Questions
Experience with Condition
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To be satisfactorily answered the question
must be focused and well articulated for all
4 parts of its "anatomy"
• the patient or problem being addressed;
• the intervention or exposure being
considered;
• the comparison intervention or exposure,
when relevant;
• the clinical outcomes of interest.
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How can you recognize and formulate
clinical questions as they occur?
• pay careful attention to the questions that
spontaneously occur to you.
• listen for the question behind the question
• what can I use for a sprain
• might become
• is a topical NSAID like aspirin more effective than
paracetamol at enabling resumption of sport at 1
week?
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What if too many questions arise?
• patients may have several active problems
– possible questions about diagnosis, prognosis, therapy
for each problem
– your questions may be too numerous to even ask, let
alone answer.
• What is the most important issue for this patient
now?
• Which question, when answered, will help me
most?
• then selecting from the many the few questions
that are most important to answer right away.
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Three Part Question
1.In adults with heart disease
2. does the addition of an ACE inhibitor to
their present treatment
3. reduce mortality
• intervention - looking for addition
• endpoints - mortality (could be morbidity)
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Exercise 5 Mins
• Clinical case
• Important or frequent question
• Structure
– Problem
44 yr old M
Chest Pain
80 yr old OA
knee
– Intervention
– Comparison
– Outcome
ECG
Exclude
Top NSAID
Oral Nsaid
Less
MI
Pain
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What is the best evidence?
• Friend once told me
• Group of old
Professors
• Case series
• Systematic Review
• RCT
• Case control trial
• Case
– http://cebm.jr2.ox.ac.uk
/docs/levels.html
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Search for Evidence
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Correct Database(s)
High Sensitivity
Wildcards * ?
MESH
Related Articles
Then specify (limit) ie Systematic Reviews
Language, human, etc
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Plan Search
Patient
Problem
Intervention Outcome
Adult*
Angina
ACE
Survive
Diabetic
Heart
Disease
Angiotensin
Not Dead
Middle
Aged
MI
Enalapril
Mortality
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Appraise Evidence
• Easy if it has been done before
– Journal of Evidence-Based Medicine
(demonstrate)
– American College of Physicians journal
– Cochrane database
• Have an appraisal course
• Use a journal club
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Appraise using JAMA Guide
Evidence-Based Medicine Working Group
• Are the results valid?
• What are the results?
• Will the results help me in patient care?
• http://medicine.ucsf.edu/resources/guideline
s/users.html
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Requirements of New Treatment
• The drug must have specific defined mode of action.
• It must be tested on a well defined disease.
• The time of action must be observed.
• The effect of the drug must be seen to occur constantly in
many cases.
• The experimentation must be done with the human body,
for testing a drug on a lion or a horse might not prove
anything about its effect on man.
• Ibn Sina [981-1037]
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Types of health care professional
Evidence
generator
Evidence Users
Evidence
Finders
Evidence Ignorer
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Current Information
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Experiential
Colleagues
Patients
Guidelines
Books
• Research
Source
Fast
Variable
Fast
Lost
Fast
Access
Fast
Fast
Fast
Buried
Lengthy
Quality
Dubious
Unclear
hmmm
Good
Variable
Slow
Lengthy
Variable
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What I want
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not to have to wade through papers
not to have to go on line with Medline
to have an index of the strength of evidence
to have a one word answer
to see questions that already have answers
15 seconds to medical knowledge
Critically Appraised Topic
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Declarative title
Question
Name of paper
Search terms
Design
Setting
Patients
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Intervention
Outcome Measures
Results
Table
Conclusion
Commentary
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A suspicious breast lump in a young woman is not necessarily cancer.
Suspicion of a breast lump in women under 50 is not highly predictive of breast cancer (12.3%) and reassurance can
be given. In older women breast lumps are more likley to be malignant (41%).
Citation/s: Seltzer M, The significance of Breast Complaints as correlated with age and breast cancer. Am Surg 1992 58(7)
413-7
Three-part Clinical Question: In women presenting with breast lumps what is the likilehood that the lump is a cancer?
Search Terms: MESH Breast-neoplasms/diagnosis, predictive value of tests, lump. 2 articles selected
The Study Patients: Women ( 93% white) presenting at the author's personal practice between 1987 and 1990 in New
Hersey, USA.
Prognostic Factor: Breast Lump clinically needing biopsy and patients accepting referral (n=399)
The Outcome: Breast Cancer
There was a well-defined sample at a uniform (early) stage of illness. Follow-up was long enough; follow-up was complete.
Can't tell if there were blind, objective outcome criteria. Adjustment was made for other prognostic factors. There was no
validation in an independent test-set of patients.
Prognostic Factor
Outcome
Result
Measure
Confidence Interval
Independent?
Breast Lump (age
Cancer
12.3%
Biopsy
8.55-15.9
no
Breast Lump (age>=50) requiring biopsy
Cancer
41.2%
Biopsy
31.3-51.7
no
Comments: This is an American study that is only one doctor's practice. However it is similar to findings from
another study in this cat bank.
Appraised by: Dr M DawesCEBM; 22 August 2000
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Email: [email protected]
Update By: When new data published - August 2001
Global Medical Knowledge
Database (Alex)
• Database (Index) of questions
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With answers linked (indexed)
Yes/ No/Maybe
Strength of Evidence
Set out as in EBM (CAT - Critically Appraised
Topic)
• Objective, Design, Setting, Patients, Intervention,
Main Results, Conclusion, Commentary
– Date/ Who Appraised
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Aims for Alex
• To appraise articles about problems that are
common or serious
• To translate these into answered questions
• To have a database of questions sorted by
topic, drug, key word etc
• To make appraised evidence available
within 15 seconds
• On your desktop or Psion
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Software to generate knowledge
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How will it work?
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If 1% of the health professionals
From around the world
Wrote two CAT’s per year
What a database we would have!!
Needs peer review, updating, free access,
and paper versions.
• This is the future……..
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http://cebm.jr2.ox.ac.uk
Thank You
[email protected]