Transcript Kein Folientitel - Occupational Asthma

SERUM CONCENTRATION OF ACE, NEOPTERIN, TNF-α AND SIL-2R IN
HEALTHY WORKERS EXPOSED TO DIFFERENT METAL DUSTS
Harald C Ott, Christian Prior, Manfred Herold, Markus Riha, Guenter Ott
Department of Cardiac Surgery, Department of Medicine, University Hospital Innsbruck
RESULTS:
Chronic lead and hard-metal exposure can cause severe
occupational lung disease.
Neopterin nmol/l
The aim of the study was to detect early adverse effects of
chronic inhalative metal dust and fume exposure by
measurement of different serum markers.
6,0
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8,0
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15
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4,0
TNF-alpha pg/ml
INTRODUCTION:
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10
p<0,001
p<0,01
p<0,05
5
2,0
PATIENTS:
0
155 healthy employees of a glass manufacturer company, a
hard-metal plant, a tool manufacturer company and a
biochemical plant were examined:
lead
hard-m e tal M oO3
coolant
organic
• 14 workers exposed to molybdenum dust and fumes
sIL-2R ng/ml
• 38 workers exposed to hard-metal dust
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2,0
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1,0
• 17 workers exposed to hard-metal grinding-coolant aerosol
• 29 workers exposed to organic dust
0,0
lead
hard-m e tal M oO3
coolant
organic
60
METHODS:
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40
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coolant
organic
Lead exposure triggers sIL-2R and TNF-α release. Hard-metal
exposure induces TNF-α release. Grinding-coolant exposure
induces TNF-α and neopterin release. Molybdenum exposure
causes Neopterin release.
CONCLUSION:
Each of the studied inhalative exposures seemes to induce a
characteristic cytokine pattern and therefore a specific inflammatory
answer. This can be considered as an early adverse effect.
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ACE U/l
Blood samples were collected during a routine medical
check up, the serum was separated and the serum probes
were kept frozen auntil further analysis.
hard-m e tal M oO3
Fig.1 to 4: Serum levels of Neopterin, sIL-2R, ACE and TNF-alpha
in different groups of workers
3,0
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• 57 workers exposed to lead dust and fumes
lead
Increased levels of the serum markers measured in this study are a
common finding in patients suffering from active interstitial lung
disease. Wether our observations highlight an ongoing disease or
indicate only a physiological reaction remains unclear.
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Serum concentrations were determined using commercially
available enzyme assays
0
lead
har d-m e tal M oO3
coolant organic
Corresponding author:
Harald C Ott MD, Department of Cardiac Surgery,
University Hospital Innsbruck, Anichstraße , 6020
Innsbruck, AUSTRIA, Fax: 00435125042528, Phone:
00435125043806, e-mail: [email protected]