Transcript Resveratrol - Solano Community College

Resveratrol
A Phytochemical With Health
Benefits Found in Red Wine
Chem 11
Spring 2008
Resveratrol is a stilbene

Stilbene:
Resveratrol
Resveratrol
Health Benefits of Phytochemicals
 Antoxidant
 Cancer
activity
inhibition
 Cholestrol
regulation
 Anti-inflammatory
activity

What are Antioxidants?
– They are substances that slow or prevent the
oxidation of other molecules, particularly by
such oxidizing agents as free radicals.

What are Free Radicals?
– They are molecular or atomic species with
one or more unpaired electrons making it very
reactive.
Free Radicals

Where do they come from?
– Many are produced in the body from O2 as
part of normal metabolic activity.
– Most of the O2 is consumed in the electron
chain transport, but some escapes this
pathway.
Free Radical Formation
2O2 + NADPH
2O2- + 2H+
2O2- + NADP+ + H+
dismutase
H2O2 + O2- + H+
H2O2 + O2
H2O + O2 + OH
Effects of Free Radicals

Negative Effects
– Aging
– Cancer
– Disruption of normal cell
activities
– Heart disease
– Damage DNA

Positive Effects
– The body uses the most
dangerous free radicals for
use in the immune system and
in inflammatory reactions.
Other Sources of Free Radicals
Drugs
 Air Pollution
 Radiation, e.g. sunlight,
TV and microwaves

Free radicals


A common Free Radical is OH
This is created in body during normal metabolism in the
ETC.
Free Radicals Attack Cellular
Membranes

Free radicals break the double bonds of
lipids found in cellular membranes:
-C=C- + OH
-C–COH
OH
Antioxidants Mop Up Loose Free Radicals
+ OH

OH
O
OH
Antioxidant
Free Radical
O
+ H2O
Antioxidant Capabilities of
Resveratrol
Research Studies Of Resveratrol

Studies are still in initial stages.

Anti-cancer, antiviral, neuroprotective, anti-aging and
anti-inflammatory.

Anti-cancer – Resveratrol interfers with all three stages;
it has anti-angiogenic properties

Anti-aging – enzyme SIR2 increases life span of yeast
cell and Resveratrol increases its activity

Drinking a glass of red wine a day may cut a man's risk
of prostate cancer in half.
Bottom Line
There may not be enough Resveratrol in a
glass of wine to yield clinical benefits, but
it’s like chicken soup …
A little bit won’t hurt you and it might do
you some good.
Works cited
National Cancer Institution. “Antioxidants and Cancer Prevention: Fact Sheet.” 2008 May 10. <http://www.cancer.gov/
cancertopics/factsheet/antioxidantsprevention>.
National Cancer Institution. “Red Wine and Cancer Prevention: Fact Sheet.” 2008 May 10. <http://www.cancer.gov/
cancertopics/factsheet/red-wine-and-cancer-prevention>.
“New Insights into the Mechanism of Action of Antioxidants.” 2008 May 10 <http://ods.od.nih.gov/news/conferences/
ada2002/Milner_ abstract.html>
Sharma, H. M.D., C. Clark, M.D. An excerpt from the medical textbook Contemporary Ayurveda. Edinburgh: Churchill
Livingstone, 1998. 2008 May 10.< http://www.bsherman.org/freeradicals.htm>.
Silverthorn, Dee Unglaub. Human Physiology: An Integrated Approach. 4th ed. San Francisco: Pearson
Educaton Inc. 2007. 22
J Bauer, D Sinclair, “Therapeutic potential of Resvertrol: the in vivo evidence”, National Revue Drug Discovery, 2006,
5(6): 494 – 506
K Huwitz, D Sinclair, “Small molecule activatiors of sirtuins extend Saccharomyces cerevisiae lifespan”, Nature, 2003
Sep 11:425 191 – 6
Ming-Tsan Lin, Men-Luh Yen, Chia-Yi Lin, and Min-Liang Kuo, “Inhibition of Vascular Endothelial Growth
Factor-Induced Angiogenesis by Resveratrol through Interruption of Src-Dependent Vascular Endothelial Cadherin
Tyrosine Phosphorylation”, Mol Pharmacol 2003, 64:1029-1036