Transcript Slide 1

Life course model of cognitive reserve
Advanced Psychometrics Methods
Web Conference – 2/16/10
Workgroup Members
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Angela Jefferson (AJ) [email protected]
Laura Gibbons (LEG) [email protected]
Dorene Rentz (DR) [email protected]
Janessa Carvalho (JC) [email protected]
Jennifer Manly (JM) [email protected]
Yaakov Stern (YS) [email protected]
David Bennett (DB) [email protected]
Rich Jones (RNJ) [email protected]
MAP Life Course Factors
Cognitive Activities Scale (CAS)
• Early-life activities (ZCAE)
• Mid-life activities (ZCA40)
• Late-life activities (ZCA99)
Socioeconomic Status (SES)
• Early childhood SES (ZSESEARLY)
• Adult SES (ZSESNOED)
Education Level (ZEDUC)
Late life reading ability - NART (ZSCREAD)
MAP Cognitive Protocol
Factor
Neuropsychological Test
WMS-R Logical Memory – Story A
Episodic Memory
East Boston Story
Global Cognition
Summary Measure of All Tests
Word List Learning
Judgment of Line Orientation – 15 item
Visospatial Ability
Raven’s Progressive Matrices – 16 item
Boston Naming Test – 15 item
Semantic Memory
Verbal Fluency
WMS-R Digit Span
Working Memory
Digit Ordering
Symbol Digit Modalities Test
Perceptual Speed
Number Comparison
Stroop Color-Word Interference
Basic model for all cognitive outcomes
Results – total MAP sample
Perceptual
speed
Episodic
memory
Working
memory
Visuospatial
Memory
Semantic
Memory*
Global*
ZCA99
.291
.150
.056
.120
.244
.211
ZCA40
.140
.072
.027
.058
.117
.100
ZCAE
.142
.068
.039
.061
.123
.103
ZSESNOED
.137
.027
.129
.080
.146
.108
ZSESEARLY
.188
.132
.165
.185
.189
.201
ZEDUC
.232
.219
.280
.322
.249
.308
ZSCREAD
.248
.204
.343
.163
.189
.284
Model R2
.260
.127
.211
.175
.217
.309
Results –MAP sample excluding “possible”
dementia
Perceptual
speed
Episodic
memory
Working
memory
Visuospatial
Memory
Semantic
Memory*
Global*
ZCA99
.269
.055
.050
.150
.191
.186
ZCA40
.131
.027
.024
.073
.092
.090
ZCAE
.135
.031
.040
.072
.100
.097
ZSESNOED
.139
.057
.149
.052
.132
.128
ZSESEARLY
.202
.170
.165
.181
.203
.252
ZEDUC
.247
.327
.265
.308
.293
.408
ZSCREAD
.228
.216
.315
.114
.166
.296
Model R2
.249
.167
.192
.162
.207
.353
Results –MAP sample including ONLY
“possible” dementia
Perceptual
speed
Episodic
memory
Working
memory
Visuospatial
Memory
Semantic
Memory*
Global*
ZCA99
.339
.205
.017
.037
.295
.262
ZCA40
.158
.096
.008
.017
.137
.121
ZCAE
.152
.078
.011
.025
.137
.115
ZSESNOED
.124
-.083
.048
.111
.159
.073
ZSESEARLY
.128
.062
.155
.200
.137
.171
ZEDUC
.167
.113
.303
.373
.183
.283
ZSCREAD
.222
.106
.331
.118
.180
.271
Model R2
.233
.078
.186
.175
.203
.264
Life Course Factors – Preliminary Conclusions
Global Cognition & Visuospatial Abilities
•Education exerts greatest influence
Episodic Memory & Semantic Memory
•Education exerts greatest influence (except for in MCI/early
cognitive decline, in which late life cognitive activities have
greatest influence)
Working Memory
•NART exerts greatest influence
Perceptual Speed
•Late life cognitive activities has greatest influence
Life Course Factors – Project Status
Statistical Analyses
•“work in progress”
Manuscript Development
•Target completion late March 2010
Recent Abstract Submission
•ICAD 2010 (Hawaii) – submitted 2/01/10
Possible Future Manuscript Development
•Examine life course factors in relation to neuropathological
markers