IR-4 August 2004
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Transcript IR-4 August 2004
2008 IR-4 Food Use Workshop
Sacramento, CA
Nichino America Inc.
Jim Adams, Manager, Product Development
Marie Maks-Regulatory Affairs Manager
Phone: (302) 636-9001
Web site: www.nichino.net
Tolfenpyrad
NAI-2302 15EC
NAI-2303 15SC
Chemical Details on Tolfenpyrad
Chemical Name: 4-chloro-3-ethyl-1-methyl-N-[4-p-
tolyloxy)benzyl] pyrazole -5-carboxamide
Empirical Formula: C21H22Cl N3O2
Molecular Weight: 283.9
Code Number: NAI-2302
Insects Controlled
Hemiptera, Coleoptera, Diptera, Lepidoptera,
Thysanoptera, and Acarina
Poisoning by ingestion; contact activity; anti-feeding
activity against leps
Target Crops:
Vegetables, Cucurbits, Cole Crops
Fruits & Nuts
Selected row crops
Ornamentals
Efficacy Trials
Use rate 0.137 to 0.274 lb. a.i/acre (153-307
grams ai / hectare)
14 – 27 oz/a (15% EC and 15% SC
formulations)
Alternative mode of action useful against
numerous vegetable and fruit/nut pests
U.S. Registration Timeline
Submit non-crop indoor greenhouse use
mid 2008 as reduced risk candidate
Submit crop uses with residue chemistry
data by 2010 as reduced risk candidate
Flubendiamide-Based
Insecticides
NNI-0771
NNI-0772
NNI-0776
NAI-2310 (FLUBENDIAMIDE)
I
CH3 CH3O O
S
HN
CH3
O
NH
O
CH3
CF3
F
CF3
New generation of chemistry active against Lepidoptera at low rates
Discovered by NNC and marketed by NNC and Bayer
Registered in Japan as Phoenix
FLUBENDIAMIDE
Product Characteristics
Flubendiamide (NAI-2310)
Target Mkts: TNV, Vegetables, Cotton
Chemistry: Substituted phtallic acid diamide
MOA: Ryanodine receptor modulator
Ingestion by insect results in immediate cessation
of feeding
Contact (not systemic in plants and has only
limited translaminar movement)
Rates: 15-140 gms ai/hectare
2009 Introductions
NNI-0772 (Tourismo™)
Tree Nuts, Pome, Stone, Vines, Cotton
NNI-0871 (Vetica™)
Vegetables, Cucurbits, Cole Crops
US Registration Timeline
Submission to EPA 2008
Commercial Launch 2009
Pyrifluquinazon
NNI-0101
Pyrifluquinazon (NNI-0101)
Hemiptera / Homptera
Rates: 12.5-50 grams ai/hectare
Whitefly, Aphids
Rates: 50-125 grams ai/hectare
Mealybug, thrips, leafhopper
Higher Rates:
Scale
True bugs
Biological mode of action on aphids
NNI-0101 shows two distinct effects on aphids;
1. Rapid response of abnormal behavior (insect dispersion, feeding cessation)
2. Slow lethal action
Appearance of activity/Green peach aphid
100
Percent of dispersal insects
(stop feeding) & mortality
80
Abnormal behavior
(insects may appear normal)
Death by starvation
60
Mortality of NNI-0101 treated insects
40
% of dispe rsion
of NNI-0101 treated insects
20
Mortality of starve d
inse cts
0
0
20
40
60
80
100
Hours after treatment
Figure 1. Mortality and percent of insect dispersal from treated plants of green peach aphid,
Myzus persicae, after treatment with NNI-0101 at a dose rate of 50ppm.
Possible IR-4 Interests
Onion thrips (PCR submitted)
Aphid, Thrip, Whitefly, Mealybug and Scale
control on ornamentals
Rapid cessation of whitefly and aphid
feeding reduces transmission of viruses
vectored by these pests on important fruit
and vegetable crops
US Registration Timeline
Submit for food crop uses early 2010