Transcript Slide 1

LC Omega-3 Oils: Delivery Systems for Food and
Supplement Applications
Ernesto Hernandez, Ph.D.
Omega Protein
Houston, TX
www.omegapure.com
R&DA. Fall 2010 Meeting. “New Military Challenges” , Incline Village, NV, Oct. 25-27, 2010.
Presentation Outline

Background on healthy oils
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Processing and Stabilizing Omega-3s
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Delivery Systems for Omega-3. Foods
and Supplements

Outlook for the future
Role of Fats in Nutrition
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Lipids are a major source of storage energy
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Important precursors in the body's metabolic processes
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Essential components of cell membranes and other biological
structures
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Play important roles in absorption of fat-soluble nutrients i.e.,
vitamins A, D, E, and K and carotenoids
•
Fats and oils are important in processing, quality, and in the
organoleptic and texture properties of food products
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Source of essential fatty acids (omega-3 and omega-6)
Composition of Vegetable Oils
Fatty acid
SOYBEAN
CANOLA
CORN
COTTON
OLIVE
PALM
Palmitic, (C16: 0)
11 %
4%
12%
25%
13%
42%
Stearic, (C18: 0)
4%
2%
2%
2%
2%
5%
Oleic, (C18: 1)
23%
64%
27%
18%
71%
40%
Linoleic, (C18: 2)
53%
19%
57%
54%
10%
11%
Linolenic, (C18: 3)
8%
9%
1%
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Fatty Acid Composition of Omega-3
Oils
Fatty Acid
Menhaden
Anchovy
Cod Liver
Microalgae
Flax
Lauric (C12: 0)
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6%
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Myristic (C14: 0)
7%
8%
4%
19%
Palmitic (C16: 0)
19%
16%
9%
17%
6%
Palmitoleic (C16: 1)
12%
9%
10%
2%
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Stearic (C18: 0)
3%
3%
4%
1%
4%
Oleic (C18: 1)
13%
9%
20%
9%
21%
Linoleic (C18: 2)
2%
4%
1%
1%
16%
Linolenic (C18: 3)
2%
1%
2%
4%
56%
Eicosapentanoic
(C20: 5) (EPA)
13%
18%
14%
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Docosahexanoic
(22: 6) (DHA)
12%
11%
12%
46%
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Why Omega-3?
Clinical Studies with LC Omega 3s
High Triglycerides
High blood pressure
Infant mental & visual development
Secondary CVD
Primary CVD
Rheumatoid Arthritis
Asthma
Inflammation: GI tract
Neurologic disordersa
Depression
Bipolar disorder
New lipid bioactives from EPA/DHA:
Protectins and Resolvins
22
Types of Long-Chain Omega-3
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
22
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Necessary for brain and eye
development
Reduces occurrence of secondary
heart attacks
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Promotes cell turnover
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Supports immune system
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Supports healthy development
of blood cells and vessels
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Promotes blood flow
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Protects cells
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Reduces inflammation
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Allows for nutrient transport through
cellular membranes
Short-Chain Omega-3
Long-Chain Omega-3
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Alpha-Linolenic Acid (ALA)
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Flaxseed, soy, canola
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Many sources of ALA contain elevated
amounts of n-6
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Although ALA has its own unique
health benefits, conversion to EPA &
DHA is inefficient (~1%)*
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Fish oils EPA & DHA
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Algal oils DHA
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Krill Oils EPA and DHA
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Excellent Bio-availability
* Sheila M. Innis, PhD., Child and Family Research Institute, Nutrition Research Program, “Omega-3 Fatty
Acids Maternal and Infant Nutrition” March 7, 2008
Omega-6:Omega-3 Ratio
Long-Chain Omega-3
Omega-6
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Linoleic acid
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EPA and DHA
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Soybean, corn,
vegetable oils
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Fish oil
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Impede short chain
omega-3 elongation
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Preformed EPA and DHA
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Readily incorporated into
blood plasma
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Deficient in the Western
diet
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Compete for same
enzymes
Overly abundant in
Western diets
Fish Oil Refining, Purifying and
Stabilization
Production of OmegaPure®
Free fatty acids
Protein residue
Hydratable matter
Color
Peroxides
Metals
Some contaminants
Residual soaps
Higher melting
fraction
Chill proofs the
oil
Contaminants:
Pesticides
Herbicides
PCBs,
Dioxins, Furans,
PBDEs,
Ffa’s, carboxylics
Odor and flavor
Antioxidant Systems for Fish Oil
Primary antioxidants:
Tocopherols
Rosemary extracts
BHA, BHT, TBHQ
Secondary antioxidants:
Ascorbyl palmitate
Citric acid
EDTA
Oxidative Stability of Edible Oils
160
146.75
140
OSI ( hours) @ 80°C
120
110.73
100
79.8
80
65
60
40
28.2
20
6.33
0
Safflow er Oil
Soybean Oil
Om egaPure E
Om egaPure TE
Om egaPure HSNatural
Om egaPure HSTE
Omega 3 from Supplements or
from Fortified Foods?
Marine-based Omega- 3 oils in 2008
•World production is approx 1 million tons, approx 10% goes to omega 3
ingredients.
• Global consumption of omega 3 ingredients, 71,452 MT
•North America consumption of omega 3s 26,948 MT (2008),
projected at 50,388 MT (2013)
•Dietary supplements
74.5%
•Functional foods and beverages a
13.8 %
•Animal feed
9.6 %
•Infant nutrition
1.7 %
•Pharma
0.4 %
(Frost & Sullivan )(2008)
Market Description
Supplements:
30%- EPA/DHA Fish Oil
77.3 %
40-55% EPA/DHA Concentrate
11.3 %
60-75% EPA/DHA Concentrate
1.4 %
85-95% EPA/DHA Concentrate
2.9 %
Others
7.1 %
(Frost & Sullivan )(2008)
20 kg of crude oil to make 1 kg of 90% EPA/DHA concentrate
Ethyl Ester Concentrates of EPA/DHA
•Ethyl ester concentrates (84%) of EPA/DHA are currently prescribed for
hypertriglyceridemia
•Clinical trials for mixed dyslipidemia
•Ethyl esters of EPA/DHA are approved as a pharmaceutical and supplements
Used in food in the EU
•Ethyl esters have become a major player in the pharmaceuticals and
supplements market (over 1 billion dollars for each segment)
Generic pharma EEs concentrates coming up fast
Key Lovaza patents will run out in 2012
Retail Sales of Omega-3 Enhanced Products
$6,000
$5,673
$5,229
$4,793
$5,000
$4,168
Million U.S. Dollar
$4,000
$3,517
$2,716
$3,000
$2,000
$2,000
$1,400
$820
$1,000
$400
$100
$0
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012
* These
numbers include ALA, EPA, and DHA
Source: Source: “Omega Fatty Acids: Trends in the Worldwide Food and Beverage Markets, 2nd Edition.” Packaged
Facts. www.packagedfacts.com. January 2009
Considerations
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Defined Health Benefit
Sustainable Ingredient
Kosher
Vegetarian
Allergens
Convenience
Consumer acceptance
Omega-3 to Omega-6 Ratio
Economics
Shelf life
Delivery Systems
• Oil
• Concentrates
• Powder
• Seed and Oil Blends
• Inclusions
Pros and Cons
Straight Oil
• Pro:
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Good choice for traditional shelf life/par baked products:
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Room Temperature- Weeks
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Refrigerated- Months
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Frozen- Years
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Most economical
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Clean label
• Con:
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Many bakeries unable/unwilling to handle frozen oil
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Not appropriate for shelf stable products (years)
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Depending on product, dispersion of oil may be challenging
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High cost for concentrates
Pros and Cons
Powder
• Pro:
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Provides added protection from oxidation
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Depending on technology may be best option for extended shelf life
products
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Handling/storage is less challenging (requires refrigeration)
• Con:
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Additional processing/ingredients add significant cost
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Complex label
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Depending on encapsulating material may impart unwanted flavors or
require allergen labeling
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Look for products with low free oil
Pros and Cons
Fortified Inclusion
• Pro:
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Provides added protection from oxidation
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Oil contained in flour or fat matrix decreasing reactive surface area
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Customized for size, flavor and color
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Easy to measure
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Handling/storage is less challenging (requires refrigeration)
• Con:
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Relatively complex label
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May not be desirable in homogeneous products
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Relatively low EPA & DHA load
Pros and Cons
Milled Flax & Oil Blend
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Pro:
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Provides added protection from oxidation
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Best Handling/storage characteristics (refrigeration not required)
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May be staged
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Provides EPA, DHA and ALA
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Clean label
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Cost offset by increased yields & additional functional attributes
Con:
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Relatively low EPA and DHA load
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May not be desirable in fine crumb/light products
Process Recommendations
• Minimize time at temperature
• Add ingredient as close to end of process as possible
• Blend oil with other fats/oils to insure even distribution
• Minimize air incorporation
• Add chelators to help retard oxidation
• Encapsulate mineral premixes
®
OmegaPure Menhaden Oil
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1st with direct GRAS approval (21 CFR
184.1472)
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Vertically integrated (supply and traceability)
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Harvested in U.S. waters
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Clean label (single species)
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Certified Kosher by the Orthodox Union
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Sustainable
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Equal balance of EPA and DHA
EPA
12-15%
DHA
10-14%
EPA + DHA
DPA
25-27%
2-3%
Total Omega-3 Fatty Acids
32-37%
MeadowPure® UltraGrad™
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Patent-pending combination of MeadowPure™ flaxseed and
OmegaPure® fish oil - containing all three forms of Omega-3
– ALA, EPA, and DHA
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Superior stability in processed foods and beverages
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Excellent clean flavor
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Allowable Nutrient Content and Structure Function claims for
ALA, EPA, and DHA Omega 3
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Free flowing powder; ambient storage
Situation Assessment Summary
One the fastest growing areas for health and wellness promotion
and disease prevention
Government recommendations (RDA’s) not here yet
Food companies slow to fortify (cost, no RDI)
Global standards for human use (CODEX) coming soon
Omega-3 concentrates are expected to swiftly move into the
pharmaceutical market in the next couple of years.
Pharmaceuticals and supplements are expected to be the largest applications for
omega-3 concentrates in the next 5 to 10 years. Frost and Sullivan, 2009.
Nutritional armor. Major application for omega-3 EPA and DHA fatty acids.
Thank you!