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Energy Balance and Body Composition Chapter 8 ENERGY IN OUT Energy Balance Excess energy is stored as fat Stored fat used for energy between meals Energy balance: energy in = energy out A shift in balance causes weight changes fat changes body composition changes- LBM, H2O 1 pound of fat = 3500 kcalories Health fat storage 50,000 - 200,000 kcal Energy In: Food Composition Direct measure of food’s energy value Bomb calorimeter Indirect measure of energy released Oxygen consumed Heat released kCalorie calculations from grams prot, CHO, fat, EtOH Thermometer measures temperature changes Insulated container keeps heat from escaping Motorized stirrer Reaction chamber (bomb) Food is burned Heating element Water in which temperature increase from burning food is measured Energy In: Kcal Intake Hunger: pain that causes food-seeking Appetite: integrated response to nerve signals and chemical messengers Hypothalamus GI hormones, neuropeptide Y Satiation – fullness, stops eating Satiety – fullness that lasts til next meal Influences that override physiological signals positive (parties) and negative (grief) 1 Physiological influences • Empty stomach • Gastric contractions • Absence of nutrients in small intestine • GI hormones • Endorphins (the brain’s pleasure chemicals) are triggered by the smell, sight, or taste of foods, enhancing the desire for them 5 Postabsorptive influences 1 Hunger (after nutrients enter the blood) • Nutrients in the blood signal the brain (via nerves and hormones) about their availability, use, and storage • As nutrients dwindle satiety diminishes. 5 Satiety: Several • Hunger develops hours later 2 Sensory influences • Thought, sight, smell, sound, taste of food 2 Seek food and start meal 4 Satiation: End meal 3 Keep eating 4 Postingestive influences (after food enters the digestive tract) • Food in stomach triggers stretch receptors • Nutrients in small intestine elicit hormones (for example, fat elicits cholecystokinin, which slows gastric emptying) 3 Cognitive influences • Presence of others, social stimulation • Perception of hunger, awareness of fullness • Favorite foods, foods with special meanings • Time of day • Abundance of Energy In: Kcal Intake Overriding hunger and satiety Stress eating and comfort foods External cues time of day availability sight, smell of food Environmental influences Example: buffet, large portion size Energy In: Kcal Intake Sustaining satiation and satiety Nutrient composition Protein is most satiating Low-energy density / High-fiber foods also more satiating High-fat foods – stimulate appetite –low satiation –strong satiety from SI (cholecystokinin) 837 kcal 71 g fat 55 kcal 3 g fat For the same size portion, peanuts deliver more than 15 times the kcalories and 20 times the fat of popcorn. 100 kcal 9 g fat 100 kcal 5 g fat For the same number of kcalories, a person can have a few high-fat peanuts or almost 2 cups of high-fiber popcorn. (This comparison used oilbased popcorn; using air-popped popcorn would double the amount of popcorn in this example.) 837 kcal 71 g fat 55 kcal 3 g fat For the same size portion, peanuts deliver more than 15 times the kcalories and 20 times the fat of popcorn. 100 kcal 9 g fat 100 kcal 5 g fat For the same number of kcalories, a person can have a few high-fat peanuts or almost 2 cups of high-fiber popcorn. (This comparison used oil-based popcorn; using air-popped popcorn would double the amount of popcorn in this example.) Energy In: Kcal Intake The Hypothalamus Control center for eating Integrates messages from brain, GI, liver Energy intake, expenditure, storage Gastrointestinal hormones- see list in margin Energy Out: Kcal expended Thermogenesis- heat generated when kcal broken down Total energy expenditure reflects 4 categories of thermogenesis Basal metabolism Physical activity Food consumption Adaptation Components of Energy Expenditure Basal Metabolism Uses about two-thirds of energy expended in a day Metabolic activities All basic processes of life Basal metabolic rate (BMR) Variations for sleep and awake Weight Lean tissue Resting metabolic rate (RMR) not as precise Components of Energy Expenditure – Physical Activity Voluntary movement of skeletal muscles Most variable component of energy expenditure Amount of energy needed depends on Muscle mass Body weight Activity Frequency, intensity, and duration Components of Energy Expenditure – Thermic Effect of Food Use kcal to digest/absorb kcal Acceleration of GI tract functioning in response to food presence Requires energy, releases heat CHO: 5-10%, Fat: 0-5%, Protein: 20-30% Approximately 10 percent of energy intake High-protein foods > high-fat foods Regular meal > snacking 30-50% Physical activities 10% Thermic effect of food 50-65% Basal metabolism Components of Energy Expenditure – Adaptive Thermogenesis Adapt to dramatic change in temperature, trauma, exertion (extra work done by body) Amount expended is extremely variable Not included in energy requirement calculations Heat loss and energy expenditure relative to surface area Estimating Energy Requirements Gender BMR and LBM Growth Groups with adjusted energy requirements Age LBM, hormones, activity level Physical activity PA Factor Body composition & body size Height Weight Height / weight file:///E:/Media/Anim ations/chapter8/08h t1.html Quick Calorie Ranges •To gain weight: 35-45 kcal/kg •To maintain weight: 25-35 kcal/kg •To lose weight: 15-25 kcal/kg Body Weight, Composition, Health Height/Weight indices unrelated to body composition Both in use health for nutritional assessment Subjective “body image” dictates behaviors Ideal Body Weight (IBW) Body Mass Index (BMI) Useful for epidemiological studies Body composition is healthy IBW / BMI says he is overweight Defining Healthy Body Weight Defining Healthy Body Weight Body mass index Relative weight for height BMI = weight (kg) height (m)2 Health-related classifications Healthy weight: BMI = 18.5 to 24.9 Overweight: BMI = 25 to 29.9 Obese: BMI = 30 to 39.9 Morbidly Obese: BMI > 40 Table 1 Proposed range of ideal weights for women, ages 25 and over, Height (with shoes) Weight in pounds (as ordinarily dressed) Small frame Medium frame Large frame 5' 0" 105–13 5' 1" 107–15 5' 2" 110–18 5' 3" 113–21 5' 4" 116–25 5' 5" 119–28 5' 6" 123–32 5' 7" 126–36 5' 8" 129–39 5' 9" 133–43 5' 10" 136–47 5' 11" 139–50 6' 0" 141–53 112–20 114–22 117–25 120–28 124–32 127–35 130–40 134–44 137–47 141–51 145–55 148–58 151–63 119–29 121–31 124–35 127–38 131–42 133–45 138–50 142–54 145–58 149–62 152–66 155–69 160–74 Source: Metropolitan Life Insurance Company 1942 Centers for Disease Control BMI is a fairly reliable indicator of body fatness for most people. BMI does not measure body fat directly, but research has shown that BMI correlates to direct measures of body fat, such as underwater weighing and dual energy x-ray absorptiometry (DXA).1, 2 BMI can be considered an alternative for direct measures of body fat. Additionally, BMI is an inexpensive and easy-to-perform method of screening for weight categories that may lead to health problems. BMI is used as a screening tool to identify possible weight problems for adults. However, BMI is not a diagnostic tool. For example, a person may have a high BMI. However, to determine if excess weight is a health risk, a healthcare provider would need to perform further assessments. These assessments might include skinfold thickness measurements, evaluations of diet, physical activity, family history, and other appropriate health screenings. Centers for Disease Control Why does CDC use BMI to measure overweight and obesity? Calculating BMI is one of the best methods for population assessment of overweight and obesity. Because calculation requires only height and weight, it is inexpensive and easy to use for clinicians and for the general public. BMI inches and pounds formula: weight (lb) / [height (in)]2 x 703 Example: Weight = 150 lbs, Height = 5'5" (65") Calculation: [150 ÷ (65)2] x 703 = 24.96 Assessing Your Weight and Health Risk BMI calculator file:///E:/Media/Animations/chapter8/08ht2.html Assessment of weight and health risk involves using three key measures: Body mass index (BMI) Waist circumference Risk factors for diseases and conditions associated with obesity What 2 BMI ranges look like http://www.flickr.com/photos/77367764@N0 0/1462394033/in/set-72157602199008819/ http://www.flickr.com/photos/77367764@N0 0/1458201494/in/set-72157602199008819/ Clinical Ht/Wt Measures IBW: Traditional ht/wt index Women: 100 lbs + 5 lbs/in > 5 ft (5”4” = 120 lbs) Men: 106 lbs + 6 lbs/in > 5 ft (6’2” = 190 lbs) UBW: Usual Body Weight- average weight past 5-10 yrs. Useless reference point unless person has been in good health ABW: Adjusted Body Weight- necessary for setting kcal needs with OW/obese persons. IBW + 1/3 excess wt = ABW Excess Weight and Disease Body Weights in U.S. Adults Healthy weight (BMI 18.5 – 24.9) Overweight (BMI 25 – 29.9) Obesity (BMI 30 – 39.9) Underweight (BMI < 18.5) Extreme obesity (BMI ≥ 40) Body Fat and Its Distribution Important information for disease risk How much of weight is fat? Where is fat located? Ideal amount of body fat depends on person Normal wt man- 13-21% Normal wt woman- 23-31% Upper level for general disease risk Young men- 22%; Men over 40- 25% Young women- 32%; Women over 40- 35% Body Fat and Its Distribution Body Fat and Its Distribution Needing less body fat Some athletes: 5-10% men, 15-20% women Needing more body fat Cold climate, pregnancy Fat distribution affects health risk Visceral fat / central obesity / apple-shaped Subcutaneous fat / lower body fat / pear-shaped In healthy-weight people, some fat is stored around the organs of the abdomen. In overweight people, excess abdominal fat increases the risks of diseases. Upper-body fat is more common in men than in women and is closely associated with heart disease, stroke, diabetes, hypertension, and some types of cancer. Lower body fat is more common in women than in men and is not usually associated with chronic diseases. Body Fat and Its Distribution Waist circumference Indicator of fat distribution & central obesity Indicator of high risk for diabetes and CVD Women: greater than 35 inches Men: greater than 40 inches Waist-to-hip ratio Other techniques for body composition More precise measures Body Fat and Its Distribution Skinfold measures estimate body fat by using a caliper to gauge the thickness of a fold of skin on the back of the arm (over the triceps), below the shoulder blade (subscapular), and in other places (including lower-body sites) and then comparing these measurements with standards. Hydrodensitometry measures body density by weighing the person first on land and then again while submerged in water. The difference between the person’s actual weight and underwater weight provides a measure of the body’s volume. A mathematical equation using the two measurements (volume and actual weight) determines body density, from which the percentage of body fat can be estimated. Bioelectrical impedance measures body fat by using a low-intensity electrical current. Because electrolyte-containing fluids, which readily conduct an electrical current, are found primarily in lean body tissues, the leaner the person, the less resistance to the current. The measurement of electrical resistance is then used in a mathematical equation to estimate the percentage of body fat. Air displacement plethysmography estimates body composition by having a person sit inside a chamber while computerized sensors determine the amount of air displaced by the person’s body. Dual energy X-ray absorptiometry (DEXA) uses two low-dose X-rays that differentiate among fat-free soft tissue (lean body mass), fat tissue, and bone tissue, providing a precise measurement of total fat and its distribution in all but extremely obese subjects. Health Risks Associated with Body Weight & Body Fat 15 20 25 30 35 Body mass index 40 Risk increases as BMI rises Risk increases as BMI declines Mortality Health Risks Associated with Body Weight & Body Fat Body weight and fat distribution correlate with disease risk and life expectancy Correlations are likelihoods, not causes Risks associated with being underweight Fighting against wasting diseases Menstrual irregularities and infertility Osteoporosis and bone fractures Health Risks Associated with Underweight 1st question is WHY underweight? Smoking, substance abuse, body image Cancer, malnutrition, thyroid dz Risks associated with being underweight No reserves against wasting diseases Menstrual irregularities and infertility Osteoporosis and bone fractures Health Risks Associated with Overweight and Obesity Risks associated with being overweight Obesity is a designated disease Health risks include: DM, Htn, CVD, sleep apnea, osteoarthritis, cancer, gallbladder dz, kidney stones, resp. problems, CHF Likely to be disabled / immobile in later years Costs billions $$$ 300,000 obesity-related deaths/year Weight Gain > 20 lbs or 4 BMI units Body mass index history and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Am J Clin Nutr. 2006 Aug;84(2):427-33. Schienkiewitz A, Schulze MB, Hoffmann K, Kroke A, Boeing H. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Germany. [email protected] Severe weight gain defined as > 4 BMI units Body mass index history and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. BACKGROUND: Obesity and increases in body weight in adults are considered to be among the most important risk factors for type 2 diabetes. OBJECTIVE: The objective was to evaluate and compare the associations between weight changes during 2 different periods of adult life and the risk of type 2 diabetes and age at diagnosis. Body mass index history and risk of type 2 diabetes DESIGN: The study included 7720 men and 10,371 women from the European Prospective Investigation into Cancer and Nutrition (EPIC)Potsdam Study with information on weight history; 390 men and 303 women of these participants received a clinical diagnosis of type 2 diabetes during 7 y of follow-up. Multivariate Cox regression models were used to estimate the relative risk (RR) of weight changes between ages 25 and 40 y and ages 40 and 55 y. Body mass index history and risk of type 2 diabetes RESULTS: RR estimates in men and women were slightly higher for each unit of BMI gain between ages 25 and 40 y [men: 1.25 (95% CI: 1.21, 1.30); women: 1.24 (1.20, 1.27)] than between ages 40 and 55 y [men: 1.13 (1.10, 1.16); women: 1.11 (1.08, 1.14)]. Severe weight gain between ages 25 and 40 y was associated with a higher diabetes risk in men (1.5 times) and in women (4.3 times) than were stable weight in early adulthood and weight gain in later life, and it resulted in an average lower age at diabetes diagnosis in men (5 y) and in women (3 y). Body mass index history and risk of type 2 diabetes CONCLUSION: Weight gain in early adulthood is related to a higher risk and earlier onset of type 2 diabetes than is weight gain between 40 and 55 y of age. Health Risks Associated with Excess Body Weight & Body Fat Cardiovascular disease High LDL, Low HDL, Htn, DM Metabolic Syndrome & Inflammation Htn, High WC, TG, ser. Glucose; low HDL Diabetes – type II Central obesity Weight gains and body weight Cancer Especially hormone-mediated Health Risks Associated with Body Weight & Body Fat Inflammation & metabolic syndrome Change in body’s metabolism Cluster of symptoms Fat accumulation Inflammation Elevated blood lipids Promote inflammation Double Whammy Highlight 8 Eating Disorders Eating Disorders Three disorders Anorexia nervosa Bulimia nervosa Binge eating disorder Prevalence of various eating disorders Causes Multiple factors Athletes and eating disorders Female Athlete Triad Disordered eating Unsuitable weight standards Body composition differences Risk factors for eating disorders in athletes Amenorrhea Characteristics Osteoporosis Stress fractures Female Athlete Triad Other Dangerous Practices of Athletes Muscle dysmorphia Characteristic behaviors Similarities to others with distorted body images Food deprivation and dehydration practices Impair physical performance Reduce muscle strength Decrease anaerobic power Reduce endurance capacity Anorexia Nervosa Distorted body image Central to diagnosis Cannot be self-diagnosed Malnutrition Impacts brain function and judgment Causes lethargy, confusion, and delirium Denial Levels are high among anorexics Anorexia Nervosa Need for self-control Protein-energy malnutrition (PEM) Similar to marasmus Impact on body Growth ceases and normal development falters Changes in heart size and strength Other bodily consequences Anorexia Nervosa Treatment Multidisciplinary approach Food and weight issues Relationship issues After recovery Energy intakes and eating behaviors may not return to normal High mortality rate among psychiatric disorders Anorexia Nervosa Bulimia Nervosa Distinct and more prevalent than anorexia nervosa True incidence is difficult to establish Secretive nature Not as physically apparent Common background characteristics of bulimics Bulimia Nervosa Binge-purge cycle Lack of control Consume food for emotional comfort Cannot stop Done in secret Purge Cathartic Emetic Shame and guilt Bulimia Nervosa Negative self-perceptions Restrictive dieting Purging Binge eating Stepped Art Fig. H8-2, p. 266 Bulimia Nervosa Physical consequences of binge-purge cycle Subclinical malnutrition Effects Physical effects Tooth erosion, red eyes, calloused hands Clinical depression and substance abuse rates are high Bulimia Nervosa Treatment Discontinuing purging and restrictive diet habits Learn to eat three meals a day Plus snacks Treatment team Length of recovery Overlap between anorexia nervosa and bulimia nervosa Bulimia Nervosa Binge-Eating Disorder Periodic binging Typically no purging Contrast with bulimia nervosa Compare with bulimia nervosa Feelings Differences between obese binge eaters and obese people who do not binge Behavioral disorder responsive to treatment Eating Disorders in Society Society plays central role in eating disorders Known only in developed nations More prevalent as wealth increases Food becomes plentiful Body dissatisfaction Characteristics of disordered eating