Transcript Analyzing Karyotypes

Nondisjunction – means “not coming apart”; when
homologous chromosomes fail to separate, abnormal
chromosome numbers may find their way into
gametes


Monosomy – missing one chromosome from a pair

Trisomy – having three copies of a chromosome
 Ex] Trisomy 21 – extra chromosome-21
A karyotype displays a diploid number
of chromosomes.
Human Female Karyotype
Autosomes
Sex Chromosomes
Notation: 46, XY
Notation: 46, XX
Is this person a male or a
female?

 Male
What condition does this
person have?
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 Trisomy 21 / Downs Syndrome
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What was it caused by?
 Nondisjunction
What notation would you
use to characterize this
patient’s karyotype?

 47, XY, +21
Jacob’s Syndrome
1.
Turner’s Syndrome
2.
Cri-Du-Chat
3.
Klinefeleter’s Syndrome
4.
5.
6.
Trisomy 13: Patau’s Syndrome
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You may not want to look at the next slide.
Trisomy 18: Edward’s Syndrome
7.
Trisomy 21: Down’s Syndrome
8.