Transcript Introduction to Physiology: The Cell and General Physiology

Muscle Metabolic Systems
Figure 84-1; Guyton & Hall
Copyright © 2006 by Elsevier, Inc.
Muscle Metabolic Systems
• phosphate
– enough stored for 8-10 sec max work
– can supply 4x ATP/min as aerobic
• glycolysis
–
–
–
–
anaerobic
strongly inhibited by low pH
forms lactic acid
can supply 2.5x ATP/min as aerobic
Copyright © 2006 by Elsevier, Inc.
Muscle Metabolic Systems
• aerobic can last indefinitely
• metabolic recovery
– lactic acid-->glucose-->glycogen
– oxygen debt
• restoration depends on carbohydrate in diet
– requires 48 hr
Copyright © 2006 by Elsevier, Inc.
Oxygen Debt
Copyright © 2006 by Elsevier, Inc.
Restoration of Glycogen is Dependent on Diet
Figure 84-3; Guyton & Hall
Copyright © 2006 by Elsevier, Inc.
Muscle
• Endurance
– largely a function of glycogen stores in muscle cells and liver
– dependent on diet
endurance (min) glycogen(g/Kg)
– hi carb diet
240
40
– mixed diet
120
20
– hi fat diet
85
6
Copyright © 2006 by Elsevier, Inc.
Endurance is Dependent on Diet
Figure 84-4; Guyton & Hall
Copyright © 2006 by Elsevier, Inc.