Transcript Narrow Sized Dual-functional Microcapsules: Contact

Carl Wei He (presenter)
Dr. Song Liu
University of Manitoba

Background
 Concepts of Microcapsules
 Applications (esp. in textiles)

Antimicrobial polyurea microcapsules
 Objective: provide contact wound dressings;
 Design: Feature and reasoning of the method

Details and characterizations
 Shell thickness
 Drug release
 Contact antimicrobial property

Future research
Polyurea
Artificial blood cells
medicine
Targeted/Triggered release
Multi- functional carrier
Electronic ink
engineering
Water treatment
Self-healing resin
Polyurea microcapsules
(PUMC)
Traditional
applications
Textiles
Agricultures

Cosmetic textiles

Aromatherapy & Fragrance Textiles

Thermochromic & Photochromic textiles

Pest repellent textiles

Thermo regulating textiles

Flame retardant textiles
Dual functions:
 On-contact antimicrobial property
 To provide an active shell surface

Controlled drug release property
 To control the thickness of shell
Application
 Chronic wound care dressing:
 infection control and nutrition supply

Morphology:
 controlled size and size distribution

Shell: matrix property:
 Stiff enough to retain spherical shape
 Thick enough to provide mass regulation

Shell: Surface property:
 Easily dispersed in water for application
 Contact-killing effect

Modification by incorporating a
multifunctional surfactant
▪
▪
▪
▪
Reduce interface tension
Provide antimicrobial functionality
Covalently bound to the matrix
Increase shell thickness
QAs
a
b
c
MC+Q
d
f
MCQ100
e
Cross-section of fluorescein stained model capsules; left: post-modified model
capsule; right: in-situ modified model capsule; (a)(d) freshly prepared model
capsule; (b)(e)cracked model capsules after CTAC extraction; (c)(f) close-up of
fluorescein stained shell
6.00E-07
Model capsules washed against Milli-Q water
Before/after CTAC extraction
QAs density mol/cm2
5.00E-07
4.99E-07
Before
extraction
4.00E-07
3.00E-07
After
extraction
2.00E-07
1.29E-07
1.00E-07
7.00E-08
0.00E+00
Control
MCQ100
MC+Q
Quantification of QAs density of model capsules. Error bar is generated
from 3 batch-to-batch measurements. Control: PUMC model capsule;
MCQ100: in-situ modified model capsule; MC+Q: post-modified model
capsule;
Up: in-situ modified
polyurea
microcapsules
(MCQ)
Down: control
polyurea
microcapsules
(PUMC).
(a) MCQ dispersed
in water;
(b) dry MCQ;
(c) PUMC dispersed
in water;
(d) dry PUMC
7-day in-vitro cumulative drug release profile for MCQ-Cmr; insert: first 24hr
release curve; (drug load = 3.33 wt%; efficiency = 31%)
MCQ
a
Control
Blank
b
c
(a): MCQ, Qas modified
capsule;
(b): Control, Polyurea
capsule without
modification;
(c): Blank, last batch of
washing solution of MCQ
sample.
Bacteria load:
4.54 log10 cfu/cm2;
Capsule density:
0.88 mg/cm2
MCQ
Control
Bacteria load: 1.54 log10 cfu /cm2
0.22
0.44
0.66
Density of microcapsules mg /cm2
0.88
MCQ
Control
Bacteria load: 3.54 log10 cfu /cm2
0.22
0.44
0.66
Density of microcapsules mg /cm2
0.88




Isocyanate residue on polyurea
microcapsules can be utilized for
functionalization.
On-contact antimicrobial can be achieved on
polyurea microcapsules
Sustained drug release of drug is achieved by
thick shell microcapsules.
Polyurea microcapsule of narrow size
distribution can be synthesized
 Ease of immobolization
 Larger surface for functionalization

Platform for functionalzation
 Other functional surfactants could be developted
volumn distribution ratio
30%
25%
diameter distribution
by volumn
20%
15%
10%
5%
0%
0
1
2
3
4 5 6 7
diameter /um
8
9
10
Manitoba Health Research Council (MHRC)
Operating and Establishment grants
Dr. Paul H.T. Thorlakson Foundation Fund
University of Manitoba Research Grant Program
(URGP)
Dr. Xiaochen Gu
Dr. Lingdong Li
Dr. Rick Holley
Dr. Saqer Herzallah
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