Transcript Hemodynamic disorders p.1 - Patho

Neoplasia p.1
SYLLABUS:
RBP(Robbins Basic Pathology) Chapter:
Neoplasia
Definitions
Nomenclature
Characteristics of benign and malignant neoplasms
Epidemiology
Carcinogenesis
Neoplasia p.1
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Squamous cells papilloma
CIN (slides with CIN I and CIN II)
CIN III
Squamous cell carcinoma (larynx)
Adenocarcinoma (large intestine)
Small cell lung carcinoma (= SCLC)
Squamous cells papilloma
-multiple projections
-with a central central fibrovascular cores
-covered by a typical, stratified squamous
epithelium
Squamous cells papilloma
Squamous cells papilloma
CIN
Cytological features:
- loss in the uniformity of the individual cells
- considerable pleomorphism
- hyperchromatic and enlarged nuclei
- more abundant mitotic figures also in
abnormal locations within epithelium
Loss of the typical architectural orientation of
cells
Intact basal membrane
review a few slides as they differ in grade (CIN 1 and CIN 2)
Cervical epithelium without CIN
CIN
CIN
CIN
CIN III
- normal epithelium totally replaced by
immature atypical cells, exhibiting no surface
differentiation
- intact basal membrane
CIN III
CIN III
Squamous cell carcinoma (keratinizing) (larynx)
groups of malignant cells of epithelial origin
with marked focal dyskeratosis infiltrating soft
tissues
Squamous cell carcinoma (keratinizing) (larynx)
Squamous cell carcinoma (keratinizing) (larynx)
Adenocarcinoma (large intestine)
Cytologically malignant columnar cells forming
neoplastic glands, often cribriform, with central
necrosis.
Differentiation may range from tall, columnar cells
to undifferentiated, frankly anaplastic masses.
Adenocarcinoma (large intestine)
Adenocarcinoma (large intestine)
Small cell lung carcinoma (= SCLC)
The epithelial cells are small, with scant cytoplasm, illdefined cell borders, finely granular nuclear chromatin
(salt and pepper pattern), and absent or inconspicuous
nucleoli.
The cells are round, oval, and spindle-shaped, and nuclear
molding is prominent. In general, tumor cells are smaller
than small resting lymphocytes.
The mitotic count is high.
The cells grow in clusters that exhibit neither glandular
nor squamous organization.
Necrosis is common and often extensive.
Grading is inappropriate, since all small cell carcinomas
are high grade.
Small cell lung carcinoma (= SCLC)
Small cell lung carcinoma (= SCLC)