Transcript 30th Annual AAAS Forum on Science and Technology Policy

Nanomedicine and Nanobiology
Research and CBET
Nanomedicine Workshop
August 27, 2007
Judy Raper
Division Director, Chemical, Bioengineering,
Environmental & Transport Systems
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OUTLINE
NSF,
ENG and External Forces
CBET Organization
Budget and Trends
 Nanomedicine
and Nanobiology Research
Funding
Opportunities
Questions
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NSF, ENG & EXTERNAL FORCES
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National Research Funding
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NSF Twenty Year Budget by Account
in Millions of Current Dollars
6,500
6,000
5,500
Millions of Current Dollars
5,000
4,500
4,000
3,500
3,000
2,500
2,000
1,500
1,000
500
0
88
89
90
91
92
93
94
95
96
97
98
99
00
01
02
03
04
05
06
07
08
Req Req
Fiscal Year
Research & Related Activities
Academic Research Infrastructure
Agency Operations and Award Management
National Science Board
Education & Human Resources
Major Research Equipment & Facilities Construction
Office of Inspector General
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American Competitiveness Initiative
The centerpiece of American
Competitiveness Initiative (ACI) is to
double the federal investment in key
agencies that support basic research in
physical sciences and engineering.
 Over the next 10 years, the Federal
agencies impacted are NSF, DOE
Science, and NIST.
 ACI includes three broad components:
 Research in physical sciences and engineering
(including 12 specific goals with 7 related to NSF)
 Research and Development tax incentives
 Education and workforce

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American Competitiveness Initiative
FY 2007 – FY 2016
Source: OSTP, Feb. 2006
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CBET Organization
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CBET Vision and Mission

VISION


CBET will be a global leader in identifying and enabling the most
innovative research and education at the frontiers of engineering;
inspiring the integration of physical, mathematical and/or life
sciences with engineering; and cultivating a vibrant, diverse
community in key, emerging and core areas benefiting society.
MISSION

CBET will promote and support transformative research and
education in engineering areas based on the physical, life and/or
mathematical sciences; advance scientific and engineering
knowledge; and develop a diverse, globally engaged workforce
enhancing the economy of the United States.
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Chemical, Bioengineering, Environmental,
and Transport Systems
Deputy Division Director
Bob Wellek
Chemical,
Biochemical, and
Biotechnology
Systems
Process and
Reaction Engineering
Maria Burka
Catalysis and
Biocatalysis
John Regalbuto
Biotechnology,
Biochemical
& Biomass Eng
Fred Heineken
Chemical and
Biological Separations
Rose Wesson
Division Director
Judy Raper
Transport and
Thermal Fluids
Thermal
Transport Processes
Pat Phelan
Interfacial Processes
And Thermodynamics
Bob Wellek
Particulate and
Multiphase Processes
Marc Ingber
Fluid Dynamics
Bill Schultz
Combustion, Fire, and
Plasma Systems
Phil Westmoreland
Senior Advisor
Marshall Lih
Biomedical
Engineering and
Engineering
Healthcare
Research to Aid
Persons
With Disabilities
Bob Jaeger
Biomedical
Engineering
Semahat Demir
Biophotonics, Imaging
& Sensing for Healthcare
Leon Esterowitz
Environmental
Engineering and
Sustainability
Environmental
Engineering
Marshall Lih
Environmental
Technology
Cindy Ekstein
Energy for
Sustainability
Trung Van Nguyen
Environmental
Sustainability
Bruce Hamilton
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Budget and Trends
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Engineering FY 2008 Budget Request
Dollars in Millions
Change over
FY 2006
Actual
FY 2007
FY 2008
Request Request
FY 2007
Request
Amt
%
CBET
$125.09
$124.44
$144.97
$20.53
16.5%
CMMI
148.82
152.16
174.08
21.92
14.4%
ECCS
77.91
80.90
93.96
13.06
16.1%
109.65
120.08
128.39
8.31
6.9%
99.45
108.88
116.41
7.53
6.9%
EEC
123.99
125.97
116.90
-9.07
-7.2%
EFRI
-
25.00
25.00
-
-
$628.55
$683.30
$54.75
8.7%
IIP
Small Business Innovation
Research (SBIR)
Total, ENG
$585.46
(Totals may not add due to rounding.)
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ENG and NSF Funding Rates
Research Grants
7000
35%
6000
30%
5000
25%
4000
20%
3000
15%
2000
10%
1000
5%
0
0%
FY 2000 FY 2001 FY 2002 FY 2003 FY 2004 FY 2005 FY 2006 FY 2007 FY 2008
Request Projection
ENG Proposals
ENG Awards
ENG Funding Rate
NSF Funding Rate
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CBET Success Rates
Proposals Received
All actions
2500
Number of proposals
2000
1500
1000
500
Unsolicited proposals
0
2002
2003
2004
2005
2006
2007
Year
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CBET Research Themes
FY 2008
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CBET Research Thematic Areas

Energy, Water and Sustainability


encourage utilization of research results in
active nanosystems and devices
Systems and Multi-scale Approaches


Freeman, Texas
Nanoscience and Engineering


closely aligns with the ACI goals of
hydrogen and solar energy, and research
critical to alternative energy.
overcoming barriers to quantum information
processing
Structure of Virus used
for Cancer Therapy
Young, Montana State
University
Integration of Life Sciences in Engineering
Research

VLP (Virus-Like Particle) with
attached vaccine activators
produced by the cell-free process
Swartz, Stanford
Gain advantages of “Genomic” revolution by
application of engineering way of thinking
Des Jardin,
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Biotechnology, Biochemical and Biomass Engineering (BBB)
Exploitation of Self-Organization
in Virus-like Particles (VLPs)
B. Dragnea
Indiana University
VLP Assembly Mechanism
Electrostatic interaction leads to the
formation of disordered protein-silver
complexes
Symmetric protein shells (blue)
assembled around functionalized
metallic cores (yellow) provide for
crystallization of 3D structures
Protein-protein interactions lead to the formation of a
regular capsid (protein shell of a virus)
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Biomedical Engineering (BME)
CAREER: Colloidal micelles as multifunctional vaccines
Chemoattracting microspheres:
• Chemoattractants released from hydrogel ‘carrier’ microspheres draw
immune cells (dendritic cells) to nanoparticles for delivery of
multiple drug signals
• Nanoparticles containing drug are sequestered inside carrier microsphere
until phagocytosed by attracted dendritic cell
Darrell
J. Irvine,
Darrell
Irvine,
MITMIT
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ARTIFICIAL RETINA SYSTEM
Mark Humayan




- USC
Array of tiny electrodes attached to inner surface of retina
Currently uses an external camera
Miniature intraocular camera fits within lens sac
Allows natural movement of the eye to scan the environment
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Chemical, Biochemical and Biotechnology Systems
A Synthetic Delivery
Vehicle for Gene Transfer
- “hitchhike” gene delivery nanoparticles
onto motor protein complexes
- convert chemical energy to mechanical work
- carry nanoparticle cargo toward cell nuclei
Suzie Pun,
U. of Washington
Bloodless Biosensing
with Carbon Nanotubes
- implantable capillary devices
- filled with carbon nanotubes
- monitor glucose levels
- without drawing blood
- for diabetes and other biosensors
Michael Strano, UIUC20
FUNDING OPPORTUNITIES
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Opportunities for Engineering at NSF

Disciplinary Research Programs

Investigator initiated awards (unsolicited)
 February 1 – March 1
 August 15 – September 15

CAREER awards
 July 18

SGER awards
 Supplements
 Workshops, Conferences

Engineering Education and Centers (EEC)


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
Engineering Research Centers (ERC)
Research Experiences for Undergraduates (REU) Sites
Research Experiences for Teachers (RET) Sites
Unsolicited Education awards
Industrial Innovation and Partnerships (IIP)

Partnership for Innovation
 Industry/University Cooperative Research Centers
 SBIR/STTR Programs
 GOALI Awards
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Opportunities for Engineering at NSF (cont’d)

Office of Integrative Affairs (IA)


Directorate of Computer Information Science and
Engineering (CISE)



Science and Technology Centers (STC)
Division of Experimental & Integrative Affairs
Combined Research Curriculum Development & Educational
Innovation Program (CRCD)
Directorate of Education and Human Resources (EHR)

Division of Undergraduate Education (DUE)
 Course, Curriculum, and Laboratory Improvement (CCLI)

Division of Graduate Education (DGE)
 Integrative Graduate Education and Research Training (IGERT)
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Cyber-Enabled Discovery & Innovation (CDI)
“Broaden the Nation’s capability for innovation by
developing a new generation of computationally based
discovery concepts and tools to deal with complex, datarich, and interacting systems.”


ENG broadly supports research in advanced cyberenabled engineering throughout all its divisions.
CDI investments areas include:
 Complex interactions
 Computational experimentation
 Knowledge extraction
 Virtual environments
 Education in computational discovery
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CAREER
The Faculty Early Career Development (CAREER)
Program: a Foundation-wide activity that offers the NSF’s
most prestigious awards for new faculty members.
Recognizes and supports the early career-development
activities of those teacher-scholars who are most likely to
become the academic leaders of the 21st century.
Awardees selected on the basis of creative, careerdevelopment plans that integrate research and education.
Full Proposal Deadline Date: July 17/18/19, 2008
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Grant Opportunities for Academic
Liaison with Industry (GOALI)

Improve the nation’s capacity for intellectual and
economic growth by serving as a catalyst for
university and industry partnerships




Aims to synergize industry-university partnerships
by enabling linkages:




Effective mechanism for transfer of knowledge between academe and
industry
Promotes fundamental research topics not undertaken by industry
Supports industry-university educational programs
Interdisciplinary university-industry collaborative projects (up to 3
years)
Faculty, postdoctoral fellows and students in industry (up to 1 year)
Industry engineers and scientists in academe (up to 1 year)
Supported by all NSF Directorates
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Small Grants for Exploratory Research (SGER)
High-risk research in the fields of science,
engineering and education





Preliminary work on untested and novel ideas
Ventures into emerging research areas
Application of new expertise or new approaches to research
topics
Quick-response research on unanticipated events
Efforts to catalyze rapid and innovative advances

submit to individual programs only after discussion with Program
Manager
 two-to-five pages; the maximum award amount is $200,000 for 2 year
 $20-50k much more common – PD is limited in total amount he/she can
award as SGERs
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Emerging Frontiers in Research and Innovation (EFRI)



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
~$25 million each year
Topics change each year
Pre-proposal required
PI plus two co-PIs from at least three disciplines
$500,000/year for 4 years
FY 2008 Topics

Resilient and Sustainable Infrastructure
 Design, renew, expand, monitor, and control critical interdependent infrastructures to
be both resilient and sustainable

Cognitive Optimization and Prediction through Reverse
Engineering
 Understanding subsymbolic intelligence can lead to development of new designs and
algorithms for optimal decision making and prediction in engineered systems
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COGNITIVE OPTIMIZATION AND PREDICTION:
FROM NEURAL SYSTEMS TO NEUROTECHNOLOGY (COPN)
 to
understand how massively parallel
circuits in brains and the associated
system identification circuits address
complex tasks in adaptive optimal decisionmaking and prediction.
 to
develop cognitive engineered designs or
algorithms for optimal dynamic decisionmaking and/or prediction.
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Important Information (NSF 07-579)

Proposal Information

www.nsf.gov/eng/efri
Team Proposals Only:
 3 or more PIs
 3 or more disciplines




Award size will depend on the type of research program proposed
Up to 4 years in duration
Up to $500K/year (direct and indirect cost)
FY08 Dates

Sep 5, 2007
 Sep 25, 2007
 Oct 26, 2007
 Apr 30, 2008
Information Webcast
Letters of Intent Due (required)
Preliminary Proposals Deadline
Full Proposals Deadline
(by invitation)
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Thank You
Questions
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