Transcript Bio 449 Lecture 3 Outline Aug. 30, 2008

Bio 449
Lecture 27 – Renal Physiology III
Nephrons (conclusion)
Mechanisms of reabsorption and secretion
Summary of nephron function
Regulation of kidney function
Anti-diuretic hormone
Renin - angiotensin - aldosterone system
Atrial natriuretic factor
Local control of kidney function
Myogenic regulation
Tubuloglomerular feedback
Nov. 12, 2010
Terms to Know
Anti-diuretic hormone
(ADH, aka vasopressin)
Aquaporin
Juxtaglomerular apparatus
Macula densa
Granular cells
Aldosterone
Renin
Angiotensin I & II
Angiotensinogen
Atrial Natriuretic Factor (ANF)
Baroreceptor
Osmoreceptor
Readings
Lectures 25-27:
Chapters 19 & 20
Nephrons
Mechanisms of reabsorption and secretion
Summary of nephron function
Distal tubule
Peritubular capillaries
Efferent
arteriole
Glomerulus
Afferent
arteriole
Bowman’s
capsule
Proximal
tubule
KEY
= Filtration: blood to lumen
= Reabsorption: lumen to blood
Loop
of
Henle
Collecting
duct
= Secretion: blood to lumen
= Excretion: lumen to external
environment
Fig. 19-1
To bladder and
external environment
To renal
vein
Summary of nephron function
Transported*/
Diffused Out
Impermeable to
—
—
300
120
Proximal Tubule
NaCl, glucose, a.a.,
H2O, some urea
Less permeable to urea
300
40
Descending limb
H2 O
NaCl
1200
15
Thin ascending
NaCl
H2 O
–
–
Thick ascending
NaCl
H2 O
100
15
Some NaCl
H2O varies
H2O permeability varies
Varies
(100-300)
Varies
(10-15)
Some NaCl, some urea
H2O permeability varies
H2O varies
Varies
(100-1400)
Varies
(0.25 – 15,
average = 1)
Location
Bowman’s
Distal tubule
Collecting duct
Final Osmolarity Final Volume
(mOsm)
(ml / min)
Regulation of kidney function
Anti-diuretic hormone
Renin - angiotensin - aldosterone system
Atrial natriuretic factor
Local control
Summary of nephron function
Bowman’s capsule
Efferent arteriole
Ascending
limb of loop
of Henle
Glomerulus
Macula densa cells
Proximal tubule
Granular cells
Afferent arteriole
Fig. 19-9