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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research
Over 40 per cent of Sweden’s academic
medical research
© Anders Kallersand
7/16/2015
1
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research at KI
 KI is Sweden’s only medical university and the
country’s largest centre for medical education
and research.
 Karolinska Institutet accounts for over 40 per
cent of the medical academic research
conducted in Sweden.
© Magnus Aldemark
7/16/2015
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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research: from molecule to patient
 22 departments
 600 research groups
 1,500 researchers/teachers, including over
300 professors
 2,000 doctoral students
© Erik G Svensson
© Lennart Nilsson / Scanpix
7/16/2015
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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Education and research at KI, 2011
KI Solna campus
1,130 annual FTE students
Research SEK 1,423 million
1,817 annual FTE employees
Danderyds Hospital
189 annual FTE students
Research SEK 33 million
31 annual FTE
employees
Karolinska University
Hospital
1,330 annual FTE students
Research SEK 1,218 million
1,143 annual FTE employees
KI Huddinge campus with
Karolinska University Hospital
2,940 annual FTE students
Research SEK 850 million
1,074 annual FTE employees
Stockholm South
General (Söder) hospital
226 annual FTE students
Research SEK 39 million
44 annual FTE employees
“Research” indicates total assets, excluding
premises and ALF funding.
2011 Annual report
7/16/2015
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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Over 80 per cent of KI revenue goes into research
Bachelor’s/Master’s
education, 17%
Research and doctoral
education, 83%
2011 Annual report
7/16/2015
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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research potential
 Clinical research
 Epidemiology
 Science for Life Laboratory
© Marcus Erixson
7/16/2015
© Elisabet Omsén
© Pierre Zoetterman
6
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research potential: Clinical research
 More than half of KI’s 22 departments are in or
adjacent to Stockholm’s teaching hospitals
 The proximity of basic and clinical research
makes possible research of a translational
nature, where observations made at the clinical
level feed new ideas for research, and where
new experimental findings can be quickly turned
to the benefit of the patients
© Marcus Erixson
7/16/2015
7
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research potential: Epidemiology
 Sweden is a goldmine for epidemiological research
 Population registers, disease registers
 KI Biobank, Swedish Twin Registry, LifeGene
 Growing competence in biostatistics
 KI is a global leader
 Research fields include:
 Cancer
 Cardiovascular diseases
 Infections
 Inflammations
© Elisabet Omsén
 Social inequality
7/16/2015
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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research potential: SciLifeLab
 The Science for Life Laboratory is a national
resource centre and world-class laboratory for
large-scale bioscience research in the following
principal areas:
 Genomics
 Proteomics
 Bioimaging
 Bioinformatics
 SciLifeLab is the result of a joint investment with
the Royal Institute of Technology and Stockholm
and Uppsala universities
7/16/2015
© Pierre Zoetterman
9
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Scientific publications, 2010
 Approx. 3,500 scientific articles and 1,000 other
publications were authored by researchers at
Karolinska Institutet
 Approx. 60 per cent have co-authors from other
countries
 The citation rate for articles from Karolinska
Institutet is 50 per cent higher than the world
average
© Marcus Erixson
7/16/2015
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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Publications, 2001 – 2010
Number
6000
5000
Other
Letter
Editorial material
Meeting/Abstract
Review
Article
4000
3000
2000
1000
0
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Given the inevitable delay in the release of data, figures for 2011 are not included.
7/16/2015
2011 Annual report
11
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Co-publications
100%
90%
80%
70%
60%
50%
40%
30%
20%
10%
0%
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Given the inevitable delay in the release of data, figures for 2011 are not included.
7/16/2015
Co-author outside KI
Co-author outside
Sweden
Co-author in Sweden
2011 Annual report
12
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Field normalised citation scores, 2001 – 2010
Score
1.75
KI
1.50
1.25
1.00
Global
average
0.75
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Given the inevitable delay in the release of data, figures for 2011 are not included.
7/16/2015
2011 Annual report
13
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research funding
Total, 2011: 4,452 SEK million (2010: 4,405)
Government
appropriations
37%
Swedish foundations &
org.
15%
Non-Swedish
foundations and org.
3%
EU
5%
Swedish companies
4%
Financial revenue
1%
Non-Swedish
companies
2%
KI funds
1%
County and municipal
councils
10%
7/16/2015
Research councils
15%
Other government
funding
7%
2011 Annual report
14
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research funding, 2002 – 2011
SEK million
3,000
2,500
2,000
1,500
External
Government
1,000
500
0
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011
2011 Annual report
7/16/2015
15
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Revenue from the EU and USA, 2004 – 2011
SEK million
25.0
20.0
15.0
EU
10.0
American foundations
and organisations
5.0
0.0
2004 2005 2006 2007 2008 2009 2010 2011
2011 Annual report
7/16/2015
16
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
The Board of Research
 Strategies
22 Departments
 Research funding and recruitment
 Research
 Research networks
 Doctoral education
 Research centres
 Core facilities
 Career service for junior faculty
 Laboratory biosafety and ethics
© Marcus Erixson
7/16/2015
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Core facilities in many fields
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Core facilities in many fields
 Biobanks
 Bioinformatics and biostatistics
 Clinical trial centres
 Experimental models
 Expression analysis
 Genomics
 Imaging and visualization techniques
 Proteomics
 Biosafety laboratory (BSL-3)
© Erik G Svensson
7/16/2015
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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
National centres
 CERIC – The Centre for Research on
Inflammation and Cardiovascular
Disease (Linné)
 CRisP – The Linné Centre for
Prevention of Breast and Prostate
Cancer (Linné)
 DBRM – The Centre of Excellence in
Developmental Biology for
Regenerative Medicine (Linné)
 ARC – The Aging Research Centre
(FAS)
 The Centre for Research on Hearing
Loss in Working Life (FAS)
 CHESS – Centre for Health Equity
Studies (FAS)
 Stockholm Brain Institute (VINNOVA)
 STARGET – a cancer research
network (Linné)
 The Human Regenerative Map
(Linné)
7/16/2015
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Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Strategic research areas
Financed through the government’s strategic
programme, 2009–2014
 SRP Cancer
 SRP Diabetes – in association with Umeå
University
 SRP Epidemiology
 SRP Molecular biosciences(SciLifeLab) – in
association with the Royal Institute of Technology
and Stockholm University
 SRP Neuroscience – in association with Umeå
University
 SRP Stem cells and regenerative medicine
 SRP Care sciences – in association with Umeå
University
7/16/2015
© Sofia Lindberg
20
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
KI’s research spans a broad field, from
basic experimental research to patientend research and care sciences.
© Erik G Svensson
7/16/2015
21
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
From basic experimental research to patient-end
research in the fields of
 Cancer and haematology
 Cell, molecular and structure biology
 Circulation and respiration
 Developmental biology, stem cells, reproductive,
regenerative and reparative medicine
 Endocrinology and metabolism
 Epidemiology and public health
 Care sciences
 Immunology, infection, inflammation and
microbiology
 Neuroscience, psychiatry and behavioural science
7/16/2015
© Erik G Svensson
22
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Cancer and haematology
 Basic research into mechanisms for the origin and
development of cancer
 Development of therapies; e.g. hormone, immune and
gene therapy
 Clinic-centred research on diseases of the blood and
blood-forming organs
 Epidemiological research on underlying causes
 Optimisation of radiotherapy
 Diagnostic development
 Life quality
© Lennart Nilsson / Boehringer Ingelheim / Scanpix
7/16/2015
23
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Cell, molecular and structure biology
 Function and composition of cells, proteins and
DNA
 Research in all disease areas
Special resource:
 Science for Life Laboratory
– for large-scale analysis in the fields of
 Genomics
 Proteomics
 Bioimaging
 Bioinformatics
7/16/2015
© Lennart Nilsson / Scanpix
24
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Circulation and respiration
 Long tradition of strong, clinical research
 Supplemented strongly with basic research in later
decades
 Today has a clear orientation towards translational
research
 Research focuses on
 Cardiovascular diseases
 Atherosclerosis
 Heart failure
 Other vascular diseases, such as diabetes complications
and kidney failure
 Lung medicine
 Asthma
 COPD
7/16/2015
© Lennart Nilsson / Scanpix
25
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Developmental biology, stem cells, reproductive,
regenerative and reparative medicine
From experimental stem cell
research…
…to clinical application in reparative
medicine
Research focuses include
 International leader in developmental
biology research
 Diabetes
 Strong clinical expertise in cell therapy
and transplantation medicine
 Post-cardiac infarction tissue damage
 Broad-based research in tissue and
locomotion – diseases, therapy and
rehabilitation
 Medical rehabilitation
7/16/2015
 Parkinson’s disease
 Spinal injuries
 Diseases of the musculoskeletal organs
 Involuntary childlessness
 Odontology
© Lennart Nilsson / Scanpix
26
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Endocrinology and metabolism
Overweight
 Outstanding research in both adult and child obesity
 Close clinical links
Diabetes
 Basic diabetes research
 Research on symptoms and treatment
 Stem cell research
Cardiovascular diseases
 The significance of inflammation
 Blood lipids
 Gender aspects of diagnosis and care
7/16/2015
© Lennart Nilsson / Scanpix
27
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Epidemiology and public health
Research focuses include
 Cancer
 Cardiovascular diseases
 Neuropsychiatric diseases
 Infections and inflammations
 Links between common diseases and life
patterns and environmental factors
 Social inequality
 Insurance medicine
 Global health
7/16/2015
© Lennart Nilsson / Scanpix
28
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Care sciences
Care sciences cover prevention, care, nursing
and rehabilitation
 Research is done in five principal areas:
 Women’s and children’s health
 People who live with chronic diseases
 Elderly people with lowered activity and participation
 Cancer and palliative care and nursing
 Health and healthcare research in organisation and
leadership
© Maskot
7/16/2015
29
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Immunology, infection, inflammation and microbiology
Research focuses on
 Basal immunology and infection medicine
 Epidemiology, vaccine and prevention
 Global infections
 HIV, malaria, tuberculosis, pneumonia
 Inflammatory diseases
 Rheumatic arthritis and multiple sclerosis
 Immune deficiency and autoimmunity
 Allergies and eczema
 Asthma and COPD
 Cardiovascular diseases
7/16/2015
© Lennart Nilsson / Scanpix
30
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Research fields
Neuroscience, psychiatry and behavioural science
Approximately 20 per cent of Karolinska Institutet’s
research is in the neuroscience field
Research focuses include
 The cognitive and motor functions of the nervous
system
 Mechanisms and treatment of neurological and
psychiatric diseases
 ADHD and autism
 Dementia and Alzheimer’s disease
 Spinalcord injury
 Schizophrenia
 Suicide
 Pain
 Violence prevention
7/16/2015
© Lennart Nilsson / Scanpix
31
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Doctoral education
Creates opportunities for
 In-depth subject knowledge
 Knowledge-exchange with worldrenowned researchers
 International exchange
Entails
 Own project work in an established
research team
 Supervision by senior researchers
 Courses at doctoral level
© Erik G Svensson
7/16/2015
32
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Doctoral students, 2011
 2,133 active
 62% are women
 28% –29 years
 42% 30–39 years
 30% 40+ years
 409 new admissions
 61% are women
 46% –29 years
 36% 30–39 years
 18% 40+ years
2011 annual report
7/16/2015
© Erik G Svensson
33
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Doctoral schools
National schools in association with
other universities/university colleges
 Health care sciences
Local clinical doctoral schools in
association with the Stockholm County
Council
 Clinical psychiatry
 General medicine
 Clinical cancer research
 Epidemiology
 Global health
 Molecular medicine
 Registry-based research
 Psychiatry
 Hearing impairment in working life
7/16/2015
34
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Broad programmes for doctoral education
 Allergy, immunology and inflammation
 Environmental factors and health
 Cell biology and genetics
 Regenerative medicine
 Epidemiology
 Neuroscience
 Hearing, ears, language and speech
 Tumour biology/oncology
 Infection biology
 Cardiovascular research
 Developmental biology and cellular
signalling
 Metabolism and endocrinology
 Global health
 Healthcare sciences
7/16/2015
35
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Doctoral education – 2 degrees
Licentiate degree
Licentiate seminar
About 2 years
Examination board
Licentiate thesis
PhD degree
Public defence
About 4 years
Half-time review
Doctoral thesis
7/16/2015
36
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Public defences
Number
450
400
350
300
250
200
150
100
50
0
2001
2002
2003
2004
Men
2005
2006
Women
2007
2008
2009
2010
2011
Total
2011 Annual report
7/16/2015
37
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Board of Doctoral Education
 Strategies
22 departments
 Rules and guidelines
 Research
 Graduate schools
 Doctoral education
 Research internships
 KID funds
 Dissertation committee
© Marcus Erixson
7/16/2015
38
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
How is doctoral education financed?
 Doctoral studentships
 Doctoral grants
 ALF funds, scholarships, clinical employment or other
Financiers
 External grants
 Stockholm County Council
 Government faculty funds
 Companies
 Other organisations in related areas
7/16/2015
39
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
International exchange programmes
Karolinska Institutet has doctoral exchange agreements
in place with, e.g.
 USA – National Institute of Health and the University of
Minnesota
 Singapore – A*STAR and NUS, NTU
 Japan – RIKEN Brain Science Institute
 China – Peking University, Sun Yat-Sen, Fudan, Nanjing
 Vietnam – Hanoi Medical University
 Laos – Ministry of Health
 Uganda – Makerere University
 Finland – University of Helsinki
 Ukraine – National Medical University
 Belarus – Belarus Medical University
© Christine Olsson
7/16/2015
40
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Broad-based research collaboration
 Healthcare
 Swedish and overseas universities
 Private enterprise
© Keiko Naito
© Anders Kallersand
7/16/2015
41
Research at KI
Research funding
Organisation
Research fields
Doctoral education
Collaboration
Karolinska Institutet’s innovation system – from research
to commercial application
 Karolinska Institutet’s innovation system
promotes collaboration with the private sector
 Supports researchers in their efforts to convert
their research results into new products and
services
 Offers advice (e.g. on agreements and patents),
project management, financing and business
development support
 Gives researchers access to extensive networks
in the pharmaceutical industry and business
© Mike Kemp
7/16/2015
42
Thank you
for your time
© Erik G Svensson
7/16/2015
43