Transcript DETERMINATION OF BIOAVAILABILITY PARAMETERS

DETERMINATION
OF
BIOAVAILABILITY
PARAMETERS
GROUP ASSIGNMENT
WORK UP
DESIRED PARAMETERS
Parameters
Bioequivalence Factor,
F†
Relative Bioavailability‡
[AUC]Total (ng.Hr.ml-1)*
Cmax (ng/ml)
Tmax (Hours)
Ka (Hr-1)**
Kel (Hr-1)
T1/2 (Hr.)***
PRODUCT A
PRODUCT B
[AUC]Total
AUC

0
AUC

0
 AUC
tla st
0
 AUC

tla ts
Clast
 Cn1  Cn 
 
 t n  t n1  .....

2
K el


ELIMINATION HALF-LIFE
(T½)
0.693
T1 
K
el
2
Method of Residual
F  Dose  ka
CP 
 e kelt  e kat
Vd ka  kel

 F  Dose  ka kelt
LnCP  Ln
e
 Vd ka  kel

F  Dose  ka kat
 
e
Vd ka  kel
F  Dose  ka
• Where A = V ka  kel
d

RELATIVE BIOAVAILABILITY
AUCT , A
BAR 
AUCT ,B