Transcript Document

EDEN
Integrated Project proposal
Florence Putterman
Emerging Diseases in a changing
European Environment
The European Union is expanding to incorporate states
with significantly different working environments,
agricultural practices and human and animal disease
profiles.
At the same time, the earth's climate is in a warming
phase, a part of which may be due to human
activities. Some models suggest that this phase will
continue, with effects that will be especially pronounced
in temperate regions.
Both local and global changes may independently or in
combination have an impact on human/animal health, by
favouring the spread of diseases already found in Europe,
or the re-emergence of diseases long dormant here.
Predicting the next emerging or re-emerging
disease is virtually impossible, but we can and
should prepare now both the methods for
monitoring
the
changing
epidemiological
landscapes of Europe and the tools that must
be brought into action quickly once new
diseases appear.
Of all the diseases potentially in this grouping,
it is expected that those involving intermediate
hosts, insects, ticks or other vectors, will be
the most important.
EDEN call
FP6 call
The aim is to identify, evaluate and catalogue European
ecosystems and environmental conditions linked to
global change, which can influence the spatial and
temporal distribution and dynamics of pathogenic
agents.
A coordinated European approach is needed to provide
predictive emergence and spread models including global
and regional prevention, early warning, surveillance, and
monitoring tools and scenarios.
Coordination with international organizations and third
world countries is essential.
Keywords
The aim is to
identify,
evaluate and
catalogue
European
ecosystems and
environmental conditions
linked to global change and which can
influence
the spatial distribution
the temporal distribution and
the dynamics
of pathogenic agents.
Coordinated European
approach
Predictive emergeance
and spread models
including the following
tools and scenarios:
- Global and Regional
prevention
- Early warning
- Surveillance
- Monitoring
Coordination with
international
organisations and third
world countries.
EDEN project
Indentify a set of Indicator diseases
Tick-borne Diseases – diseases already present in Europe that have shown significant
recent increases in incidence, at least partly due to changes in human behaviour in relation to
the environment.
Rodent-borne Viruses (hanta, arena, cowpox) – widespread but under-reported diseases
within Europe, with strong links with habitat and landscape structures.
Leishmaniasis – persistent on the southern fringes of Europe and beyond (southern
Mediterranean basin), with the potential to expand as environments change.
West Nile Virus – periodic and occasionally severe local outbreaks, especially on the eastern
fringes of Europe, currently showing strong associations with landscape patterns.
Malaria – an ancient scourge of Europe, currently now on her southern and eastern fringes,
with the potential for re-emergence following environmental changes.
Africa Plateform – new strains of West Nile Virus and new diseases such as Rift Valley Fever
may be introduced to Europe from tropical regions linked by bird and other (e.g. traded
livestock) migratory routes to Europe.
Study diseases using a common appraoch
WP / Tasks
Patterns
Processes
Landscape,
Biotopes and
Habitats
Description of the
environmental components
and habitats
Monitoring of major
environmental events and
their consequences on the
cycles components
Vector Bionomics
and Competence
Inventory, vectorial
capacity and competence
of vector populations
Monitoring introduction,
establishment and spread
of vectors
Public Health and
Human Activities
Public health demography
of the human populations
at risk
Monitoring of significant
population flows between
and in countries
Animal reservoirs
Epidemiological inventory
of the receptive wild and
domestic animal
populations
Monitoring migrations
(avifauna), movements and
transport (livestock) of
the animal reservoirs
PUB/HEALTH & SOCIO
ECONOMY
AGRO/ECOLOGY
Ecosystem
Regional/local
development
Landscapes
economical /
social conditions
FOCI
Climate
Vectors
Pathogens
PATHOGENIC CYCLE
Human
activities
hosts
EDEN work packages
African Platform
Leishmaniasis
Malaria
Rodent borne diseases
Tick borne diseases
West Nile Virus
Vertical Sub-Projects (SP)
Horizontal Integration Teams (HIT)
African Platform
Data Management
Leishmaniasis
Biodiversity
Malaria
Environmental Change
Rodent borne diseases
LR Spatial Modelling
Tick borne diseases
Disease Modelling
West Nile Virus
and
Africa
Platform
Malaria
West Nile
Leishmania
Rodent
borne
Tick
borne
Ecosystem components
studies
WP1: Landscape, habitat, climate
Pattern
Process
WP2: Vector
Pattern
Process
WP3: Public Health
Pattern
Process
WP4: Animal Reservoir
Pattern
Process
WP5: Individual disease
Data management
& Modelling
Data management &
information systems
Low resolution
spatial modelling
WP6 Horizontal
activities
WP6.2
RS tools
Africa
Platform
Process
WP2: Vector
Pattern
Disease transmission
modelling
Malaria
WP1: Landscape, habitat, climate
Pattern
WP6.1 Data
management
West Nile
Rodent
borne
Leishmania
Ecosystem components
studies
Tick
borne
Horizontal integration
Process
WP3: Public Health
Pattern
Process
Environmental
change monitoring
Biodiversity
WP6.3
PhD program
WP4: Animal Reservoir
Pattern
Process
WP5: Individual disease
Data management
& Modelling
Data management &
information systems
Low resolution
spatial modelling
WP6 Horizontal
activities
WP6.2
RS tools
Africa
Platform
Malaria
Process
WP2: Vector
Pattern
Disease transmission
modelling
Process
WP3: Public Health
Pattern
Process
Environmental
change monitoring
Biodiversity
WP6.3
PhD program
Emergence
& spread models
WP1: Landscape, habitat, climate
Pattern
WP6.1 Data
management
West Nile
Rodent
borne
Leishmania
Ecosystem components
studies
Tick
borne
Horizontal integration
WP4: Animal Reservoir
Pattern
Process
WP5: Individual disease
Data management
& Modelling
WP7
Overall
Integration:
Tools
&
scenarios
Data management &
information systems
Low resolution
spatial modelling
WP6 Horizontal
activities
WP6.2
RS tools
Africa
Platform
Malaria
Process
WP2: Vector
Pattern
Disease transmission
modelling
Emergence
& spread models
WP1: Landscape, habitat, climate
Pattern
WP6.1 Data
management
West Nile
Rodent
borne
Leishmania
Ecosystem components
studies
Tick
borne
Horizontal integration
Process
WP3: Public Health
Pattern
Process
WP7
Overall
Integration:
Tools
&
scenarios
Environmental
change monitoring
Biodiversity
WP6.3
PhD program
WP4: Animal Reservoir
Pattern
Process
WP5: Individual disease
Data management
& Modelling
WP8: Training, Dissemination, Management & Coordination
EDEN strategy
HEALTH/ENVIRONMENT
RESEARCH
of model diseases in a variety of
representative environmental settings
Characterise (new)
transmission cycles
Identify factors
triggering emergence
and spread
TOOLS and POLICIES
Catalogue of ecosystems
and environmental
conditions at risk:
“emerging disease hotspots”
Develop predictive
emergence and spread
models
Develop early warning,
surveillance and
monitoring tools
Identify environmental
changes likely to favour
emergence
Contribute to decision
support and policy making
HEALTH/ENVIRONMENT
RESEARCH
of model diseases in a variety of
representative environmental settings
TOOLS and POLICIES
Characterise (new)
transmission cycles
Identify factors
triggering emergence
and spread
Develop predictive
emergence and spread
models
Identify environmental
changes likely to favour
emergence
EDEN strategy
document
integrated ‘transdisciplinary’
health/environment
approach.
Catalogue of ecosystems
and environmental
conditions at risk:
“emerging disease hotspots”
Develop early warning,
surveillance and
monitoring tools
Contribute to decision
support and policy making
EDEN strategy document
A key deiverable produced by the Steering Committee
with back-up from the advisory group, specialists with
internationally recognised skills in (i) biodiversity
monitoring and assessment, (ii) environmental change
detection, (iii) disease modelling, remote sensing, image
processing and interpretation, and (iv) public health.
The EDEN strategy document will propose an innovative
integrated
‘trans-disciplinary’
health/environment
approach for the unified analysis of the various EDEN
outputs. The development of such an approach will be a
major breakthrough of EDEN.
Objectives timeframe
1
2
3
4
5
SD
H&E
T&P
Dissemination
SD: EDEN Strategy document
H&E: Health/Environment research
T&P: Tools and policies
External
sources
EDEN Indicator
Diseases
Individual
diseases
models
EDEN Steering
Committee
Advisory
group
integrated models
health-environment
Knowledge Flow
DMEWS
Disease Monitoring &
Early Warning Systems
Conclusion
Annex1, chap 4.1 Contribution to the objectives of the sub-priority
“EDEN’s bold ambition is to enable a multi-DMEWS system on a solid scientific
foundation running from the theoretical understanding of the reasons for the
emergence of new diseases in vulnerable ecosystems, through an understanding of
complex disease dynamics, to the practical application of such knowledge to
disease control.
We do not know the precise shape of this future yet: EDEN presents a chance to
Europe to invest in some of the ‘brightest and best’ researchers to ensure success with
this vision, and in doing so to advance significantly the state-of-the-art and put
Europe firmly at the forefront of DMEWS.”
EDEN management
ADVISORY GROUP
Scientists, Users
Project Officer
T. Karjalainen
EDEN Coordinator
EU Focal Point
SCIENTIFIC ADVICE
R. Lancelot - CIRAD
STEERING COMMITTEE
Chairman SC
D.J. Rogers
Secretary SC
G. Hendrickx
Members Steering Committee
Vertical Sub-projects
EDEN-TBD: S. Randolph (UK)
EDEN-Robo: H. Henttonen (Fin)
EDEN-LEI: P. Ready (UK)
EDEN-WNV: P. Reiter (Fr)
EDEN-MAL: D. Fontenille (Fr)
EDEN-AFR: Y. Thiongane (Sn)
Horizontal Integration Teams
Env. Changes: E. Lambin (Be)
LRes. Mod: D. J. Rogers (UK)
Data Mngt: W. Wint (UK)
D. Modelling: H. Heesterbeek (Nd)
Biodiv: JF. Guégan (Fr)
PROJECT
MANAGEMENT TEAM
Financial Advisor
Admin Assistant
CIRAD support team
EDEN Central management
Day to Day
EDEN Coordinator
Integration
Renaud Lancelot
Chairman SC
Scientific coordination
David Rogers
Secretariat
Financial
Olivier Pierre
Administrative
Sylvie Pugin
Secretary SC
Operational
Guy Hendrickx
CIRAD
Technical inputs
Solving EDEN’s problems
EDEN - Deputy SP Coordinators
TBD
Kurt Pfister
Ludwig-Maximilians University – Munich, Germany
(LMU)
Milan Labuda
Slovak Academy of Sciences - Bratislava, Slovakia (SAS)
Robo
Herwig Leirs
University of Antwerp – Antwerp, Belgium (UA)
LEI
Montserrat Gallego
University of Barcelona - Barcelona, Spain (UB)
Robert Farkas
Szent István University - Budapest, Hungary (SZIE)
Zdenek Hubalek
Academy of Sciences of the Czech Republic – Brno,
Czech Republik (IVB)
Alessandra della Torre
University of Rome ‘La Sapienza’ - Rome, Italy (UNISAP)
Rajae El Aouad
National Institute of Hygiene - Rabat, Morocco (INH)
Gabriella Nicolescu
National Institute of Research and Development for
Microbiology and Immunology “Cantacuzino” –
Bucharest, Romania (NIRDMI)
Ouaffa Fassi Fihri
Agro-veterinary Institute – Rabat, Morocco (IAV)
Jean-François Molez
Institut de Recherche pour le Développement – Dakar,
Sénégal (IRD)
WNV
MAL
AFR
EDEN - Focal points
Topic
Person
Affiliation
Gender equality and
personnel interaction
Sarah Randolph
University of Oxford,
Oxford, UK
Ethical aspects and safety
rules of laboratory work
Kurt Pfister
Ludwig-Maximilians
University, Munich, Germany
Ethical aspects of working
with live animals
Heikki Henttonen
Finnish Forest Research
Institute, Vantaa, Finland
Gender action plan
EDEN – Advisory Group
Duane Gubler
Asia-Pacific Institute of Tropical Medicine and Infectious Diseases, John A.
Burns School of Medicine, Hawaii, USA
Santiago Mas Coma
President of the European Federation of Parasitologists (EFP), University of
Valencia, Valencia, Spain
Rainer Sauerborn
Medical Director of the Department of Tropical Hygiene and Public Health of
the University of Heidelberg, Germany
Graham White
Mosquito & Fly Research Unit, Center for Medical, Agricultural & Veterinary
Entomology, Gainesville, Florida, USA
Philippe Martin
Principal Administrator, European Commission, Directorate-General for
Health and Consumer Protection, Risk Assessment (DG-SANCO)
Bettina Menne
Senior officer, Global Change and Health Program, World Health
Organisation of the United Nations (WHO), Rome, Italy
Jan Slingenbergh
Senior officer, Insect Pest Management, Food and Agriculture Organisation
of the United Nations (FAO), Rome, Italy
Antonio Petrini
Animal Health Information Department, World Organisation for Animal
Health (OIE), Paris, France