Transcript No Slide Title

APPLICATION TO THE HADROTHERAPY
FOR OCULAR MELANOMAS
G.A. Pablo Cirrone
Qualified Medical Physicist and PhD Student
University of Catania and Laboratori Nazionali del Sud
INFN, Italy
LNS Superconducting Cyclotron
in Catania is the unique machine
in in Italy and South Europe used
for protontherapy
Depth doses in radiotherapy: single fields
120
8 MV X-rays
200 MeV protons
20 MeV electrons
cobalt 60
% dose response
100
80
60
40
20
0
0
5
10
15
20
depth cm of water
25
30
Why clinical proton beams?
• penetration depth is well-defined and adjustable
• most energy at end-of -range
• protons travel in straight lines
• dose to normal tissue minimised
• no dose beyond target
MEDICAL APPLICATION OF THE
CATANA FACILITY
Choroidal Melanoma
85 - 90 % successfully treating with
proton beams
Age related subfoveal macular
degenerations with subretinal
neovascular membrane
 About 300 new cases for year in
Italy
This is the main cause of third age
blindness in EC countries
 In the world 5000 patients have
been already treated with
proton beams
It is a “social disease” for EC
PRESENT
TREATMENT
ROOM
LAYOUT
OF LNS
•0 ° respect the switching magnet
•80 meter after extraction
•3 m proton beam line
Ligth
field
Laser
Modulator &
Range shifter
Monitor
chambers
Scattering
system
Patient ready
for treatment
DETECTORS USED FOR DOSE
DISTRIBUTION MEASUREMENTS
DEPTH DOSE DISTRIBUTION
LATERAL DOSE DISTRIBUTION
•Markus Ionization chamber
•GAF Chromic Film
•Silicon diode
•Thermoluminescent dosimeters
2
mm
Sensible Volume = 0.05 cm3
Markus Chamber layout
Irradiated GAF Chromic
Risolution 100 m for DDP and 200 m for LDP
‘PURE’ BRAGG PEAK EXPERIMENTAL RESULTS
100
Relative Ionizzation (% )
90
Markus Ionization Chamber
80
70
Scanditronix Silicon Diode
60
50
40
30
20
10
0
0
5
10
15
20
25
30
35
Depth in water (mm)
DETECTOR
PEAK
DEAPTH
PEAK PLATEAU
RATIO
F.W.H.M.
Distal - dose Practical Range
falloff
(d10% , ICRU 59)
d80%-20%
MARKUS
30.14
4.68
3.19
0.50
31.15
SILICON
DIODE
30.07
4.89
3.07
0.60
31.06
MODULATED BRAGG PEAK
110
100
Relative Dose (%)
90
80
15.4 mm SOBP
RS = 10 mm
14 mm SOBP
RS = 14 mm
70
15.5 mm SOBP
RS = 2 mm
60
50
40
30
20
10
0
0
5
10
15
20
Depth in water (mm)
MOD/RS
MOD:000
RS:14 mm
MOD:010
RS:10 mm
MOD:009
RS:1.8 mm
CCO
SOBP WIDTH
(mm eye
tissue)
Distal dose
falloff
Longitudinal
Beam Range
d80%-20%
Homogeneity (mm eye tissue)
(mm eye
tissue)
14.5
0.65
101.6
14.65
11
0.60
104
18.27
20.6
0.55
103.9
27.04
17
0.75
 102
25
30
35
EXPERIMENTAL LATERAL DOSE DISTRIBUTION
Film X
100
Microcube
sX
Signal %
80
60
40
20
0
-20
0
-5
-10
-15
5
10
15
Distance from the centre (mm)
R 90%50%
Ps
[mm]
Pd
[mm]
Simmetry
[%]
Homogeneity
at 95% level
[mm]
LNS
0.92
0.8
1
2.4
21
CCO
0.93
0.75
0.75
2.6
23
20
Geant4 applications in prothon therapy
our goals
• Simulation, design and realization of critical
elements of a proton beam line
 Scattering system
 Modulation system
 Collimators along the beam line
• Three dimensions dose distribution
verification in water at isocenter in the
treatment conditions
Comparison with experimental and treatment
planning data
Proton therapy group in Catania
•G. Cuttone Project Leader INFN
•G.A.P. Cirrone Qualified Medical Physicist
and PhD student
•V. Salamone
•L. Raffaele
Qualified Medical Physicist
•M.G. Sabini
• L. Valastro
•P. Lojacono
•V. Patti
Student for Medical
Physics Qualification