Transcript Diapositiva 1 - Sintofarm Caribe Ltda.

Sintocheck
The ideal binder for
MYCOTOXIN
DEFINITION
Mycotoxins are metabolites of molds growing on feedstuffs (Aspergillus,
Fusarium, Penicillum).They are spread everywhere and are able to bring about
poisoning in the animals that assume contaminated feed
Many mycotoxins can contaminate crops before
harvest under certain circumstances of humidity
and temperature .
 FIELD MYCOTOXINS
During the time between harvesting and drying , and in storage
 STOCK MYCOTOXINS
THE MAIN MYCOTOXINS
ASPERGILLUS
Flavus, Parasiticus
Ochraceus
AFLATOXINS (B1, B2, G1, G2)
OCHRATOXIN
FUSARIUM
Graminearum, Moniliforme
Sporotrichoides
ZEARALENONE, FUMONISIN
(DAS, T2,DON)
PENICILLUM
Cyclopium
Citrinum
Rubrum
Viridicatum
PENICILLIC ACID
CITRININ
RUBRATOXIN
OCHRATOXIN
TOXIC EFFECT OF THE MYCOTOXINS
Common is the presence of various mycotoxins, even though present
in small amounts,they add their effects,determining a synergistic effect..
…. are more dangerous at low levels of different mycotoxins than high
levels of single mycotoxin
Mycotoxins are resistant to all technological treatments.
MYCOTOXIN LEGISLATION
Directive 2002/32/EC on undesirable substances in animal feed (2006/02/24)
Undesirable
substance
Products intended for animal feed
Maximum content
in ppm relative
to a feedingstuff
with a moisture
content of 12 %
All feed materials
AFLATOXIN B1
Complete feedingstuffs for cattle,sheep and goats with
the exception of:
-complete feedingstuffs for dairy animals
-complete feedingstuffs for calves and lambs
0,02
0,02
0,005
0,01
Complete feedingstuffs for pigs and poultry (except
young animals)
0,02
Other complete feedingstuffs
0,01
Complementary feedingstuffs for cattle, sheep and
goats (except complementary feedingstuffs for dairy
animals, calves and lambs)
0,02
Complementary feedingstuffs for pigs and poultry
(except young animals)
0,02
Other complementary feedingstuffs
0,005
> (with the new normative may not be mixed for dilution!!)
MYCOTOXIN LEGISLATION
COMMISSION RECOMMENDATION of 17 August 2006
Undesirable
substance
OCHRATOXIN A
FUMONISINE
FUMONISIN
B1+B2
B1
+ B2
Products intended for animal feed
Maximum content
in ppm relative
to a feedingstuff
with a moisture
content of 12 %
Feed materials
-cereals and cereal products
0,25
Complementary and complete feedingstuffs
-complementary and complete feedingstuffs for pigs
-complementary and complete feedingstuffs for poultry
0,05
0,1
Feed materials
-maize and maize products
60
Complementary and complete feedingstuffs for::
-pigs, horses , rabbits and pet animals
-fish
-poultry, calves (< 4 months), lambs and kids
-adult ruminants (> 4 months) and minki
5
10
20
50
MYCOTOXIN LEGISLATION
COMMISSION RECOMMENDATION of 17 August 2006
Undesirable
substance
DEOXYNIVALENOL
Products intended for animal feed
Feed materials
-cereals and cereal products with the exception of
maize by-products
- maize by-products
Complementary and complete feedingstuffs with the
exception of:
-complementary and complete feedingstuffs for pigs
-complementary and complete feedingstuffs for calves
(< 4 months), lambsand, kids
ZEARALENONE
Feed materials
-cereals and cereal products with the exception of
maize by-products
- maize by-products
Complementary and complete feedingstuffs
-complementary and complete feedingstuffs for piglets
and gilts (young sows)
-complementary and complete feedingstuffs for sows
and fattening pigs
-complementary and complete feedingstuffs for calves,
dairy cattle, sheep and goats
Maximum content
in ppm relative
to a feedingstuff
with a moisture
content of 12 %
8
12
5
0,9
2
2
3
0,1
0,25
0,5
EFFECTS ON SWINE
a kidney trouble
Swine nephropaty
Vulvovaginitis
Pulmunary Oedema
Prolepsis
Embryo mortality
Oral Irritation
Feed refusal
vomiting
Liver toxicosis
Intestinal
haemorrhage
TOXIC MYCOTOXINS ON SWINE
MYCOTOXIN
SYMPTOM
TOXIC LIMIT
1000 ppb
AFLATOXIN
Liver
TRICOTECENI
(T2, DAS, DON)
Feed refusal, mucous
membrane damage(max
mouth)
T2,DAS: 3000 ppb
DON: 5000 ppb
ATTENTION LIMIT
50 ppb
500 ppb
500 ppb
1000 ppb
200 ppb
OCHRATOXIN A
Protein metabolism,
kidneys
FUMONISIN
Pulmunary oedema
50000 ppb
10000 ppb
1000 ppb
100 ppb
ZEARALENONE
Estogenic syndrome,
reproduction
EFFECTS ON SWINE
25-100 ppb of Zearalenone
(less fertility)
• Less heat during 5 days after weaning
•More anaoestrus
•Less pigglets live births more abortion; litters
less uniform
• Rectal and uterus prolapsis
500-1000 ppb of Fumonisina
( reproduction and respiratory problems)
•Increase incidence of :PRRS, APP; CRV
•Pulmunary oedema
•Unexpected death
•Less immune activity
• Increase of E.Coli in the intestinal
tract
EFFECTS ON SWINE
100-500 ppb Tricoteceni: A: T-2 e DAS;
B: DON ( digestion problems )
•Anorexia
•Vomiting (12 ppm)
•Immunodepression
•Delayed growth
•Skin and mucous necrosis
DAS: Deacetoxiscirpenolo; DON: Deossivalenolo
50- 1000 ppb AFLATOXIN
(hepatic problem)
•Anorexia
•Unexpected death (1000 ppb)
• Hepatic damage (necrosy, icterus, lipidosy,
hemorrages)
•Delayed growth
•Immunodepression
EFFECTS ON POULTRY
mucous membrane
kidn
eys
Sistema
emopoietico
ed
organi linfoidi
Reproductive
organ
Boodvessels
arti
teratogenicità
TOXIC MYCOTOXINS ON POULTRY
MYCOTOXIN
SYMPTOM
AFLATOXIN
Liver
TRICOTECENI
(T2,Das, DON)
Mouth, protein metabolism
ionofor antibiotic
OCHRATOXIN A
Protein synthesis, bigger
kidneys, increased of fecal
moisture
FUMONISIN
ZEARALENONE
TOXIC LIMIT
1000 ppb
T2, DAS:2000 ppb
DON: 10000 ppb
ATTENTION LIMIT
50 ppb
400 ppb
1000 ppb
2000 ppb
100 ppb
Nervous system
50000 ppb
10000 ppb
Reproduction,osseous system
100000 ppb
2000 ppb
EFFECTS ON POULTRY
•Immunodepression
•Less answer to vaccines
•Increase cost of therapy
•More mortality
•Less yield
TOXIC LIMIT
•Aflatoxin: 1000 pbb
•T-2, DAS: 2000 ppb
•DON: 1000 ppm
•Ochratoxin A: 2000 ppb
Necrosis
EFFECTS ON RUMINANTS
Vulvovaginitis
Gastro enteritis
Prolepsis
Intestinal haemorrhage
Immunodepression
Embryo mortality
Cystic
ovarian
Feed refusal
vomiting
Milk contamination
Decline in milk production
Increase in somatic cells
EFFECTS ON RUMINANTS
ZEARALENONE/DON
•Cistic ovarian
•Miscarriages
•More anaoestrus
•Less heat
TRICOTECENI AND OTHER
MYCOTOXIN
•Immunodepression
•Less ingestion
•Decline in milk production
AFLATOXIN B1 AND M1:they are a problem for the health of the consumer
Legislative decree n° 149 of 10 May 2004
POSSIBLE STRATEGIES IN ORDER TO PREVENT
AND TO MANAGE THE MYCOTOXIN
PROBLEMS
1 Establish an adequate quality control of feedstuffs
2 Use of mould inhibitor during storage
3 Use mycotoxins binder
ANTIMOULD ADDITIVES
They do not have to be considered the exclusive method of
control
Combinations of organic acids (propyonic, sorbic, benzoic
and acetic) or salts of organic acids (calcium propionate and
potasium sorbate)
They must be distributed uniform on all the feed
BUT ABOVE ALL
They do not have effect on the mycotoxins produced on the
field
ADDITIVES ADSORBENT MYCOTOXINS
Sintocheck
Natural Mycotoxin Binder
Composition: Hydrated Sodium Calcium Aluminosilicate (HSCAS)
New concept:
BY USING A WELL BALANCED,COMBINATION OF DIFFERENT HSCAS
THAT ARE ACTIVED BY A HEAT DRYING PROCESS ,
WE WELL OBTAIN A SYNERGIC EFFECT,INCREASING THE CAPACITY AND
SPECTRUM OF MYCOTOXIN BINDER.
WHY CLAYS ARE DIFFERENT? HOW TO
COMPARE THEM?
CEC: Cation Exchange Capacity (MEQ)
CEC VALUE IN MEQ CLAYS
3 to 20
Kaolinites and zeolities
20 to 60
Illites and chlorites (silicates)
60 to 100
Bentonites
100 to 150
Vermiculite,humic acids
< 19 MEQ is considered a saturation point,which makes the clay have a neutral
charge,it's adsorption capacity is minimal
>60 MEQ is considered a high CEC,which can interfere in
the adsorption of nutrients,especially minerals.
Sintocheck (mixture of illites and chlorites) 20-60 MEQ
WHY CLAYS ARE DIFFERENT? HOW TO
COMPARE THEM?
EXPANDABLE: Hight cation exchange,more than 60MEQ.
Absorb water.
Absorb nutrients.
NON EXPANDABLE: Lower than 60 MEQ cation exchange capacity.
Very small to almost no water absorption.
Very little to no absorption of nutrients.
Sintocheck is not expandable
DIPOLAR – POLAR
Dipolar clays have a wide spectrum of adsorption of mycotoxins.
Polar clays (such as Bentionites) have a negative charge and can only adsorb mycotoxins
with a strong positive charge
Sintocheck is dipolar
WHY CLAYS ARE DIFFERENT? HOW TO
COMPARE THEM?
PORE SIZE AND SURFACE AREA
Bentonite = Hight CEC = Smaller surface area = less binding sites
Bentonite = Pore size of 1,5 to 1,8 A
Illites and chlorites (silicates) = Smaller CEC = Larger surface activity =
more binding sites.
Illites and chlorites (silicates) = Larger pore size, in range of 2,5 A
PARTICLE SIZE
The size of particle is very critical:
-less than 300 mesh reduces the surface area
-- the best size is between 300 and 400 mesh
-at 400 mesh or higher ,particles are too small and could represent hazardous
problems to workes.
Sintocheck has a particle size , which is the best for a superior adsorbent
WHY CLAYS ARE DIFFERENT? HOW TO
COMPARE THEM?
PH
There is an interrelationship between the pH of the clay and where the binding
is performed in the GI tract of the animal.
Clays with an acid pH tend to work better in the large intestine.
Clays with an alkaline pH perform their binding in the lower intestine.
Many scientists and nutritionists believe it is better for a clay to work in the
lower intestine.
SINTOCHECK HAS A PH OF 7,8 TO 8,
THEREFORE IT PERFORMS BINDING IN THE LOWER INTESTINE
WHY CLAYS ARE DIFFERENT? HOW TO COMPARE
THEM?
TEMPERATURE WHICH THE CLAYS ARE SUBMITTED TO DURING PROCESSING
Temperature may have an effect on the cation exchange due to solubility and
temperature reationship.
Many clays are extracted from the ground ,then ground into finer particles with no
heat being applied for drying.
Drying clays at normal temperatures of 200 to 300 F°(95-150°C) can make the
clay more active and have a better cation interchange.
If excess temperature is used in drying,for example,900 F°(480°C),the components
crystallize or fragment,rendering the clay ineffective as a single component or as a
unit for mycotoxin adsorbtion.
SINTOCHECK is dried at temperature of 100 and 105 °C
which is the range of temperature which can make the clay more active and
have better cationic exchange,therefore a must better binder.
SINTOCHECK
It is different because…
Hydrated Sodium Calcium Aluminosilicate (HSCAS) natural
Big binding capacity and large spectrum of mycotoxin binder
Irriversible bond with mycotoxins
The small particle size allows an optimal homogenization with
the other feed ingredients contributing to solve also the problems
of fluidity and caking.
BINDING CAPACITY OF SINTOCHECK
SINTOCHECK is tested using 5ppm mycotoxin at inclusion level of 2,5
Kg/TON
100%
90%
99%
97%
95%
94%
84%
84%
72%
72%
43%
Aflatoxin M1
Citrinin
Aflatoxin B1
T2
Vomitoxin
Don
Fumonisin B1
Ochratoxin A
Zearalenone
80%
70%
60%
50%
40%
30%
20%
10%
0%
M1
B1 T2 VO
VOM
F.B1 0CRZEA
ZEA
A.
M1CIT A.B1
M DO F.B1
A CONCEPT OF HOW
SINTOCHECK WORKS
•
MAGNETIC ATTRACTION: A difference in electrical charge between Sintocheck and
mycotoxins.
Sintocheck
works like a
magnet
mycotoxin
2. PARTICLE SIZE: The particle size of Sintocheck provides a larger surface area that
maximizes the binding of mycotoxins.
Sintocheck
MYCOTOXIN
OTHER PRODUCT
MYCOTOXIN
A CONCEPT OF HOW SINTOCHECK WORKS
3.PORE VOLUME: SINTOCHECKhas an ideal pore volume to bind a large
percentage of mycotoxins. Using SINTOCHECK is like having a number of
magnets in one.
SINTOCHECK with
bound mycotoxins
MICOTOXIN
MICRO-BOND
MICOTOXIN
MICOTOXIN
BINDING MYCOTOXINS CAUSES A LARGER COMBINED PARTICLE OR
MOLECULAR SIZE WHICH IS NOT ADSORBED BY THE DIGESTIVE TRACT.
IT IS PASSED IN THE FECES,CAUSING NO HARM TO THE ANIMAL'S
PERFORMANCE.
SINTOCHECK
SINTOCHECK does not affect,nor is affected by
other ingredients such as:
antibiotics/medicinal
riboflavin
vitamin A- zinc - manganese
phosphorus
Dosage: 2,5 Kg/ton
SINTOCHECK
Pigs, poultry,fishes, horses, pets
Per ton of feed
Prevention of risk
1,0-1,5 Kg
Sospect of mycotoxin
1,5-2,0 Kg
Presence of
mycotoxin
2,0-2,5 Kg
Ruminants
dairy cows
60 g/head /day
beef cattle
50 g/head /da