Transcript Slide 1

Mitochondrial Electron Transport Chain
H++ H++
HH
H+
H+
OUT
Cyt C
e - e-
Q e- e-
e-
IN
Cyt C
e- e-
e- e-
- +H
+ 2O
O2 OH
H
H++H
H
O2
+H+
H2OH
H+H+-
+
+
HH+`+`HNAD
ADP
O2
.OH
NADH
ATP
.- .OO
MnSOD
Krebs
Cycle
GPx
H2O2
Fe2+
H2O + O2
Cat
Animated by Peter Rabinovitch
Background after Mandavilli et al, Mutation Research 509 (2002) 127–151
CytC
Fe-S
Fe-S
CytC
Fe-S
ADP
NADH
Krebs
Cycle
Aconitase
Fe-S
Fe-S
ATP
ADP
e-
MPTP
work
Pi
Bcl2
mtDNA
Bax
CytC
CytC
Apoptosis
Caspase 9 (active)
Caspase 9 (inactive)
APAF-1
Background after Mandavilli et al, Mutation Research 509 (2002) 127–151