Introduction to FOCUS Degradation Kinetics training course

Jos Boesten Alterra Wageningen University and Research Centre The Netherlands

Outline Introduction to FOCUS Why FOCUS Degration Kinetics ?

Working procedure Membership Trainers and training programme

Introduction to FOCUS •

FO

rum for

C

o-ordination of the

US

e of pesticide fate models in EU registration • Founded in 1992 (co-operation between Commission and ECPA) • Aim of FOCUS: – Guidance for environmental fate modelling in context of Annex VI of EEC 91/414 (“… estimate, using a suitable calculation model validated at Community level, the concentration…”)

time evolution of FOCUS workgroups

Current FOCUS workgroups Steering Committee Version Control (permanent) Degradation Kinetics 2005 Landscape & Mitigation 2005 Air 2006 Groundwater 2006

Why FOCUS Degradation Kinetics ?

Estimation of parameters for degradation kinetics (including formation of metabolites and water-sediment) in registration procedures not reproducible: Example - Notifier: submitted scenario calculations with DT50 = 33 days - registration authority: did not agree, concluded DT50 = 43 days, so redo all scenario calculations Cause: no agreed guidance, so start this workgroup

Working procedure FOCUS Deg Kin Workgroup

• Aim defined by SC (3 pages): – Detailed description of aim and boundary conditions – Time restriction • Procedure – Consensus within workgroup – Basis for any discussion is science (and pragmatism) • Product: – Guidance document

Working procedure FOCUS Deg Kin Workgroup

• Participants are scientists • Membership decided by FOCUS Steering Committee • Only money for hotel and travel expenses

Working procedure FOCUS Deg Kin Workgroup

• Steps: – Workgroup met 10 times in 2 years and produced report – Report to MS for review (2 months) – Few hundred comments – Workgroup: responded and revised report – Training for experts of all MS – Revised document to EFSA (European Food Safety Authority) for independent scientific review (6 months) • JANUARY 2006: opinion available at www.efsa.eu.int

– Review to MS and political decision on implementation

Membership of FOCUS Degradation Kinetics 8 persons 4 persons 1 chairman governmental research institutes, universities, regulatory agencies; 7 Member States ECPA (2 from Europe and 2 from US)

Members of FOCUS Degradation Kinetics Claude Beigel Otto Richter Sabine Beulke Jeremy Dyson Karin Aden Martin Dust Russell Jones Sylvia Karlsson Ton van der Linden Guy Soulas Oriol Magrans Soria Inge Fomsgaard Jos Boesten

Trainers Claude Beigel Dieter Schäfer Jeremy Dyson Jos Boesten Ralph Warren Russel Jones Sabine Beulke member of FOCUS Deg Kin WG member of ECPA Kinetics Support Group member of FOCUS Deg Kin WG chair of FOCUS Deg Kin WG member of ECPA Kinetics Support Group secretary of FOCUS Deg Kin WG member of FOCUS Deg Kin WG

Training programme 8:40-8:50 a.m.

8:50-9:00 a.m.

9:00-9:15 a.m.

9:15-9:30 a.m.

9:30-9:45 a.m.

9:45-10:00 a.m.

Introduction Jos Boesten Remit of work group Russell Jones Kinetic models considered Jeremy Dyson Optimization and statistical measures Sabine Beulke Introduction to Kinetics Software Tool Dieter Schäfer Break

Training programme 10:00-11:30 a.m.

11:30-12:00 a.m.

12:00-12:50 p.m.

12:50-2:15 p.m.

2:15-3:45 p.m.

3:45-4:15 p.m.

Data Handling Issues with hands-on session Sabine Beulke Non-equilibrium Sorption Jos Boesten Lunch Parent kinetics and hands-on session Ralph Warren Metabolites: theory and hands-on session Claude Beigel Modelmaker Demonstration Claude Beigel

Disclaimer on KinGUI software Workgroup uses software because it is easiest to use for this training Workgroup reviewed a range of software packages: no ‘ideal’ package available Use of this software in training does not imply that other software would not be suitable