Transcript Input function extraction

EXTRACTING ARTERIAL BLOOD
CURVE FROM PET IMAGE
Images containing abdominal aorta
why
 missing blood data
 noninvasive alternative



high costs of arterial sampling
other problems with arterial sampling
more reliable than arterialised venous sampling
method - what are we fitting
 only once

diameter of the vessel (needs initial value)
 for all frames separately

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center of the vessel
activity inside vessel
activity of the surrounding area
how
Known:
K
CI=activity in PET image
Unknown:
CB=final input TAC
CBG=background activity
CA=activity inside arteria
CI=(CA-CBG)*K+CBG
=>
1
CB 

1 e
* CA
R2
 FWHM 
2*

 2.355 
2
distance from the centre
of vessel
Adipose tissue study
problems & ideas
 results are very dependent on diameter value
 2D convolution might be used for testing
References
Germano et al.: Use of Abdominal Aorta for
Arterial Input Function Determination in
Hepatic and Renal PET Studies: J Nucl Med
1992; 33:613-620