Transcript ppt, 9.4 MB - University of Wisconsin–Madison

Positron Emission Tomography
(PET) at Madison
Alexander K. Converse1, Andrew D. Roberts2,
Robert J. Nickles1, Paul M. DeLuca, Jr.1
1University
of Wisconsin - Madison
2University of Manchester
Willy Fest, Madison, 10 June 2005
A. Converse UW - Madison
Technology
A. Converse UW - Madison
Applications
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Time
35 years of PET tracer production
at Wisconsin
11 MeV cyclotron
EN Tandem
NEC tandem
Noblesse of Willy, HTR, HHB, PQ
# studies/yr
100
10
1
‘70
benchmarks
5FU
pipeline ECAT II
2000
CTI 933
GE Advance
µPET, PET/CT
FDG goes commercial
15O, 13NH ,CH 18F,
3
3
FDG,.
-> several dozen PET tracers in research use
A. Converse UW - Madison
Space
WC
CS
8 uL
VA
MP
NP
5000 uL
100 uL
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Tracers
Basics
Serotonin
Blood flow
[15O]H2O, [17F]CH3F
Transporter[18F]ADAM
Blood volume
[11C]CO
Receptors 1A
Oxygen extraction
[15O]O2
Glucose metabolism
[18F]FDG
pH
[11C]CO
Bone
[18F]F-
2
Dopamine
Synthesis
[18F]FDOPA, [18F]FMT
Transporters
[11C]MP, [11C]DTBZ
Receptors D1
D2
[11C]SCH23390,
[11C]RAC, [18F]FAL,
[18F]desFAL
[18F]MPPF
More…
Tumors
[18F]Iressa, [124I]NM404,
[62Cu]ATSM, [18F]FLT
Microglial activation
[11C]PK11195
Anesthesia
[18F]halothane
Phantoms
90Y, 76Br, 64Cu, 34mCl
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Tracer Kinetics
Mintun MA, Raichle ME, Kilbourn
MR, Wooten GF, Welch MJ (1984) A
quantitative model for the in vivo
assessment of drug binding sites
with positron emission tomography.
Annals of Neurology 15:217-227
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Dopamine Release
a
b
Cd
-DBP
amph
uCi/cc
Pu
c
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Dopaminergic Neuromodulation
kl1
ligand
Clp
flow
Cf
kl2
kf1
p
kf
kl3
ClF
ClB
kl4
Cf
2
plasma
tissue
(free)
tissue
(bound)
b
activity
activity
a
time (s)
time (s)
d
activity
activity
c
time (s)
time (s)
A. Converse UW - Madison
PET People
Jerry Nickles, Ph.D.
Onofre DeJesus, Ph.D.
Dhanabalan Murali, Ph.D.
Leo Flores II, M.D., Ph.D.
Alex Converse, Ph.D.
Jon Nye, M.S.
Miguel Avila-Rodriguez, M.S.
Rachel Bartlett, B.S.
Corinne Dallas, B.S.
Nick Vandehey, B.S.
David Dick, PhD ('04)
Michael Schueller, PhD ('01)
Michael Taylor, PhD, MD ('98)
Tim Mulnix, PhD ('98)
Andy Roberts, PhD ('95)
Terry Oakes, PhD ('95)
Brad Christian, PhD ('94)
Chuck Martin, PhD ('92)
Marty Satter, PhD ('91)
John Sunderland, PhD ('90)
John Votaw, PhD ('88)
Gary Hutchins, PhD ('84)
Margaret Daube-Witherspoon, PhD ('83)
Richard Hichwa, PhD ('81)
Mark Madsen, PhD ('80)
Dave Abbott, DVM
Jesus Bianco, M.D.
Richard Davidson, Ph.D.
Paul DeLuca, Ph.D.
Ian Duncan, DVM
Sean Fain, PhD
Jim Holden, Ph.D.
Ned Kalin, M.D.
Steve Kornguth, Ph.D
Ross Levine, M.D.
Scott Perlman, M.D.
Joanne Paul-Murphy DVM
Mary Schneider, Ph.D.
Steve Shelton, Ph.D.
Charles K Stone, M.D.
Patrick Turski, M.D.
Tom Wallhaus, M.D.
Jamey Weichert, PhD
Jim Zagzebski, Ph.D.
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Willy
Enthusiasm
Focus
Rigor
“Do the simple experiment first”
A. Converse UW - Madison