Methods for and Applications of Quantitative SPECT

Participants

Medical Imaging Physics

Eric Frey, Ph.D.

Benjamin Tsui, Ph.D.

Yong Du, Ph.D.

Xin He, Ph.D.

Na Song Xing Rong Michael Ghaly Lishui Cheng

Environmental Health Science

Jonathan Links, Ph.D.

Nuclear Medicine

Richard L. Wahl, M.D.

Heather Jacene, M.D.

Frank Bengel, M.D.

Cardiology

Lew Becker, M.D.

Methods for Quantitative SPECT

Imaging Physics Applied Math Estimation Theory Quantitative SPECT Single Radionuclide: Tc-99m, Tl-201, In-111, I-131, I 123, … Simultaneous Dual Radionuclide: •Tc-99m/Tl-201 •Tc-99m/In-111 •Tc-99m/I-123 •In-111/I-131 Compensation for: •Attenuation •Scatter •Spatially varying resolution •Partial volume effects Well characterized Accuracy: <5% for organs Phantom <10% at system resolution Precision: on order of accuracy I-123 Brain 3 2 1 0 -1 -2 -3

Clinical Applications of Quantitative SPECT

• Targeted radiotherapy dosimetry • Quantitative tumor response (e.g., In-111 Octreoscan, I-123 MIBG) • Simultaneous rest/stress myocardial perfusion imaging • Simultaneous myocardial perfusion/innervation imaging