Transcript ( HFRS） Xing Jiang Hemorrhogic Fever Virus Hantaar Virus

Hemorrhogic Fever
Virus
Hemorrhogic Fever
Virus
 Hantaar Virus or HEMORRHAGIC
FEVER with renal syndrome virus
( HFRS）
 Xing Jiang Hemorrhogic Fever Virus
Hantaar Virus
(HEMORRHAGIC FEVER
with renal syndrome virus )
Morphology
 Spherical, 80-120nm
 Nucleocapsid: Helical, 3 segments, 2
proteins - nucleocapsid ('N'), RNA
polymerase ('L')
 Envelope: 2 glycoproteins, G1 and G2,
Morphology
Biological properties
1. ssRNA with long, medium,short
segments
2. Antigens 6 serotypes (I- VI)
3. Resistance: weak
Epidemiology
1. Natural host : rodents (deer mouse
(Peromyscus maniculatus), cotton rat
(Sigmodon hispidus), marsh rice rat
(Oryzomys palustris) , white-footed
mouse (Peromyscus leucopus), other
carriers)
2. Transmission : Droplet and rodent
excreta spread
3. Season and district
Clinical syndromes
 Headache;
 Pink in face , neck
 Fever
 marked bleeding tendency
 Lower blood pressure
 Urine with Protein
 multi-organ failure
Pathogenicity
1. Clinical manifestations: 5 phases
Fever phase
 Hypotension phase
 Auria phase
 Polyuria phase
 convalescent phase

Pathogenesis
 Viral direct damage
 Immunopathogenesis
Laboratory diagnosis
 Cultivation: Vero-E6 cell and A549 cell
 Serological diagnosis: IgM/IgG
indirect immunofluorescent assay
ELISA-IgM
Prevention and treatment
 Inactivated vaccine
Xing Jiang
Hemorrhogic Fever
Virus
Morphology
 Spherical, 80-120nm
 Nucleocapsid: Helical, 3 segments, 2
proteins - nucleocapsid ('N'), RNA
polymerase ('L')
 Envelope: 2 glycoproteins, G1 and G2,
Vector and Host
 Animal Host
 Hyalomma asiaticum
Pathogenesis
 Season: April and May
Prevention
 Inactivated vaccine