Transcript ppt slides

Pigmented nevi (moles)
29 patients, 41 lesions
17 benign nevi
18 dysplastic nevi
6 melanomas
Control: adjacent normal skin
Richard Langley et al., Mass. General Hospital
Key features of pigmented nevi (in progress)
Normal
versus
order
regular network of cells
polygonal or round
nested
low contrast
small, regular
symmetric
Malignant
disorder in epidermis, dermis
disrupted cell borders
irregular, atypical shapes
pagetoid distribution of cells
high contrast
elongated, thickened dendrites
eccentric melanin patterns
Richard Langley et al., J. Amer. Acad. Dermatol. 45: 365-376, 200
NORMAL HUMAN
SKIN
JUNCTIONAL
NEVUS
COMPOUND
NEVUS
DYSPLASTIC
NEVUS
Normal vs. benign pigmented lesions
Richard Langley et al., J. Amer. Acad. Dermatol. 45: 365-376, 20
NORMAL HUMAN
SKIN
LENTIGO
MALIGNA
MELANOMA
IN SITU
SS MELANOMA
IN SITU
Normal skin vs. melanomas
Richard Langley et al., J. Amer. Acad. Dermatol. 45: 365-376, 20