Transcript Presentation

Opening for registration on
November 10, 2014
https://www.synapse.org/#!Synapse:syn2813581
Lcchong, wikipedia
Introducing the
ICGC-TCGA DREAM
Somatic Mutation Calling
Tumour Heterogeneity Challenge!
• Cloud only challenge! Galaxy Interface + API.
• The Challenge :
– Determine number of subclones
– Determine mutation order
– Estimate sub-clonal proportions
– Predict lineage of evolutionary tree (ancestry)
SMC Tumour Heterogeneity Challenge Data
in silico Data
Real Data
• 50 data sets
•Released each month
•Of increasing complexity
•With different read depth
•Provide multiple samples to
recover branching structures
• Single cell sequencing data
•11 published datasets
– Ovarian cancers
– Leukemia
– Nodal breast cancers
Challenge Organizing Team
Organizers
• Paul Boutros (OICR)
• Amit Deshwar (University of Toronto)
• Quaid Morris (University of Toronto)
• Minjeong Ko (OICR)
• Josh Stuart (UCSC)
• Kyle Ellrott (UCSC)
• Adam Margolin (OHSU)
• Christopher Bare (Sage)
• Gustavo Stolovitzky (IBM)
• Kristen Dang (Sage)
• Stephan Friend (Sage)
• Yin Hu (Sage)
• Thea Norman (Sage)
• Shannon Carter (Sage)
Data Contributors
Funding/Sponsoring/Publication
Partners Include: