Charge:

• Your task is to develop core ideas/projects for an $8-10M ($1.25-1.5M per year for 5 years) NIH Center proposal.

• Specifically, you should consider the following questions

Molecular Imaging

• Group Members Peter A. Dowben Yuri L, Lyubchenko Xiao Cheng Zeng Ron Cerny Stephen DiMagno Michael Boska

Briefly describe the core projects your group would design for the Center. Please dream big.

• We envision a comprehensive center that spans molecular biology, target identification, whole cell studies, small animal, large animal, human imaging.

• Key new components of the facility include: centralized cell culture facility, an adjacent animal facility, cyclotron, preclinical PET/CT scanner, whole body MRI, small animal fluorescence scanner, imaging mass spectrometer.

• Magnetic and electric dipolar molecules with functionalities not only as MRI agents BUT also magnetocaloric and inductive heating and cooling; nanoimaging characterization of the MRI agents; imaging liqand-protected metal nanoparticles, PET, radiochemistry facility (cyclotron).

• “Donor’s Name” Institute for Translational Molecular Imaging

Identify the key faculty from from both campuses to involve in these projects. Include their strengths. (UNMC on next slide)

• UNL Faculty A. Gruverman Wai-Ning Mei (UNO) R. Sabirianov (UNO) L. Parkhurst, UNL D. Sellmyer, UNL J. Shield, UNL Stephen DiMagno Chemistry (UNL) Electrical Engineering (UNL) Biomedical Engineering (UNL) Strengths ferroelectrics electronic structure theory electronic structure theory Chemistry, fluoresence Physics, metal nanoparticles synthesis Mech. Eng., nanoparticle characterization 18 F Radiotracer synthesis

Identify the key faculty from from both campuses to involve in these projects. Include their strengths.

• UNMC Faculty Liu, Yutong Boska, Michael Sajja, Bala Strengths MRI applications, Image processing MRI applications Image processing Eppley Cancer Institute (UNMC) Molecular Biology/target ID Neurosciences (UNMC) Moleuclar/histology/animal models Cardiology (UNMC) Radiology (UNMC) Etc College of Pharmacy (UNMC)

Identify external academic partners & expertise or equipment resources/strengths that are needed to accomplish these projects.

Dana Farber Cancer Institute U. Missouri Medical Center Free University of Berlin (Institute for Inorganic Chemistry, Physical Chemistry, FU Medical Center) University of Minnesota

List potential industry/foundation partners (think broadly) and what they would contribute. Include reasons why they would be interested.

Thermo Fischer Scienticfic Health Care GE Health Care Sigma Aldrich Epichem Luna Nova Cardinal Health Siemens

Describe how you would link the Center to other campus resources.

• MRI facilities • Nanoimaging core facility, UNMC • Nanoscience facility, UNL • Mass Spectrometry facility, UNL