Transcript Emerging importance of Auger electrons

C14:
Microdosimetry in nuclear medicine:
emerging importance of Auger-electron
data
Alan Nichols
University of Surrey, UK
&
Manipal University, India
January 2013
Auger electrons and dosimetry
Cancer Therapy with Auger Electrons: Are We Almost There?
A. I. Kassis, J. Nucl. Medicine 44 (2003) 1479-1481
The Problem of Auger Emitters for Radiological Protection
D. Bingham et al., Radiation Protection Dosimetry 92 (2000)
219-228
Radiotoxicity of Iodine-125 and Other Auger-electron-emitting
Radionuclides: Background to Therapy
S. Adelstein et al., Cancer Biother. Radiopharm. 18 (2003) 301-306
The Electron Spectrum from the Atomic De-excitation of 131Xe
A. Kovalik et al., J. Electron Spectrosc. Relat. Phenom. 95 (1998)
232-254
January 2013
Intermediate-term Nuclear Data Needs for Medical Applications:
Cross Sections and Decay Data
Immediate and future:
22-26 August 2011, IAEA Headquarters, Vienna, Austria
Intermediate-term Nuclear Data Needs for Medical
Applications: Cross Sections and Decay Data
A.L. Nichols, S.M. Qaim and R. Capote Noy
IAEA report INDC(NDS)-0596, September 2011
January 2013
Therapeutic Auger-electron emitters
Radionuclide
Requirements
67Ga, 111In
Auger electrons may become
an issue
71Ge
Auger electrons may become
an issue
77Br
Auger electrons may become
an issue
99Tcm
103Pd
January 2013
Auger-electron (Ee < 25 keV)
and other low-energy
electron (Ee < 1 keV) data for
microdosimetry
Auger electrons
Comments
Both 67Ga and 111In finding
increased application in
internal radiotherapy
Regularly used for diagnosis,
but also increased application
in therapeutics
Therapeutic Auger-electron emitters
Radionuclide
Requirements
Comments
Auger electrons
Regularly used for diagnosis,
but also increased application
in therapeutics
140Nd
Auger electrons may become
an issue
Auger and EC decay; in-vivo
generator (140Pr)
178Ta
Auger electrons may become
an issue
Auger and EC decay; in-vivo
generator (178W)
193Ptm, 195Ptm
Auger electrons may become
an issue
Large number of Auger
electrons emitted
123I
197Hg
January 2013
Auger electrons may become
an issue
Auger electrons – calculational route
over to Filip and Tibor
→ C20
January 2013