Transcript multistep carcinogenesis

Figure 11.12 The Biology of Cancer (© Garland Science 2007)
Figure 11.7 The Biology of Cancer (© Garland Science 2007)
Progressive Accumulation of Genetic
Lesions in Colon Cancer
Progressive LOH
The Corresponding genetic lesions
Figure 11.9 The Biology of Cancer (© Garland Science 2007)
APC , β-CATENIN & REGULATION OF THE
INTESTINAL LINING
Figure 7.24a The Biology of Cancer (© Garland Science 2007)
Comparative Genome Analysis
Figure 11.20 The Biology of Cancer (© Garland Science 2007)
In Vivo Studies With Monozygotic Twins Show Requirement For
More Than 1 Genetic Modification
Figure 11.22b The Biology of Cancer (© Garland Science 2007)
Oncogene Collaboration
Table 11.2 The Biology of Cancer (© Garland Science 2007)
In vivo Study in Mouse Model Shows effect of
Collaborating Genetic Lesions
Figure 11.24a The Biology of Cancer (© Garland Science 2007)
Tumor Initiators and Tumor Promoters - Phenomenology
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Figure 11.28 The Biology of Cancer (© Garland Science 2007)
Initiators & Promoters – Possible Mechanisms I
Figure 11.29 The Biology of Cancer (© Garland Science 2007)
Initiators & Promoters – Possible Mechanisms II
Figure 11.30 The Biology of Cancer (© Garland Science 2007)
Table 11.4 The Biology of Cancer (© Garland Science 2007)
Inflammation and Liver Cancer
Figure 11.37b The Biology of Cancer (© Garland Science 2007)
Inflammation, Cyclooxygenase-2 (COX-2),
Prostaglandin E2 & Tumor Promotion
Figure 11.38c The Biology of Cancer (© Garland Science 2007)
Alcohol – head & neck
Table 11.3 The Biology of Cancer (© Garland Science 2007)
Mutagens vs Promoters
Figure 11.42 The Biology of Cancer (© Garland Science 2007)