World’s Leading Provider of Turn-key Compute Solutions for NGS / Bioinformatics

 Founded in 1989  Over 1000 PowerWulf Clusters Delivered World Wide  350+ PowerWulf Clusters Dedicated Compute Appliances for NGS / Bioinformatics  Mission Statement  Tier 1 Manufacturing & Support at Commodity Price  Custom Configured Products Include  Turn key PowerWulf Compute Clusters  RaidStation Storage Solutions  High Performance Workstations & Servers

 Selected by Roche / 454 and CLCbio as OEM Hardware Provider    Over 60% of ALL WORLDWIDE data off GS FLX Titanium Platform is analyzed on PSSC Labs Platform Roche’s Success in this space linked directly to PSSC Labs PowerWulf Cluster solution CLCbio is a leader in genomics software solutions  Certified our PowerWulf Clusters and Servers Compatible with Life Technologies’ Bioscope & Illumina’s Casava Applications  Pacific Biosciences considering PSSC Labs as OEM Hardware Provider  Recent LARGE Cluster Wins  Western Kentucky University – 5000+ Cores  PSSC Labs Selected after evaluation of Dell, HP, IBM   OpenX.org – 7000+ Cores  PSSC Labs Selected after evaluation of Dell, HP, IBM MIT / Harvard / HHMI Neuroimaging Center  Largest GPU Cluster at MIT  Revolutionary POWERSERVE DUO TI2000    Perfect Cluster Building Block Tool-Free Design Power Saving Eco Friendly Features  World Wide Support & Maintenance

 Partnerships w/ leading Sequencing Platform Providers  Roche / 454  OEM Provider of GS FLX Titanium Cluster ( www.pssclabs.com/roche )  Life Technologies  Certified Cluster Solutions w/ Bioscope Preconfigured  Illumina  Certified Cluster / Server Solutions w/ Casava Preconfigured  Pacific Biosciences  Potential OEM Proider of off line cluster for new RS platform  Ion Torrent  Certified Workstation w/ Ion Torrent Software  CLC Bio  Selected as OEM Hardware Provider of Genomics Machine / Factory

 Delivery Fully Functional / Turn Key Systems  Biologist are typically not system administrators. Just need a system that works out of the box.  Superior Knowledge & Support  You will have direct communication with the PSSC Labs Cluster Engineer that built, tested and configured the system with your applications.  Our Remote Assist support provides greater more responsive support than any other vendor  We Understand Your Business  Seqwright needs a knowledgeable cost effective hardware provider that ensures they deliver their customer results on time, every time.  Our systems are considered the industry’s most reliable with a failure rate >0.01%. This is a direct result of our superior testing procedure

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PSSC Labs Runs Benchmarks Provided by Application to Certify Systems

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Typical benchmarks include small and large data sets for all pipeline steps (mapping, assembly, alignment) Example

 WT Run is one of three stress tests we run to certify our clusters for Bioscope   Results: DURATION= 6 hours 36 minutes 44 secs Configuration: 8 Core (2.67 Ghz) / 48GB Memory)

 Information obtained from end users  Illumina / Casava  UCI Irvine  We are sequencing Drosophila (fruity fly) samples. The genome is approximately 1.2 x 10 8 base pairs.   One lane of paired-end, 75bp data from an Illumina GA2 machine gives about 25X coverage of a genome.  Roughly 35 million pairs of reads per lane or 2* 75 *35e6 = 5.25e10 base pairs of data. We sequence 3 lanes per sample. Pipeline involves a lot of custom software to do our analyses, and we can entirely process a single sample in about 12 hours. This is much more than simply doing the alignments  System Configuration     PowerServe Duo T2400 (Single SMP System) 8 Processor Cores / 2.4 Ghz 128 GB System Memory 40 TB USABLE High Speed Storage Space

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Information obtained from end users

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Illumina / Casava

 St. Radbound University   “Mapping one exome sample to the human reference takes about 8.5 hours using Bioscope 1.3” System Configuration    PowerWulf Cluster 64 Processor Cores / 2.53 Ghz / 8 Cores Per Node 4 GB Memory Per Core

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CLC Bio Genomics Factory Comparison

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PSSC Labs is OEM Provider of Genomics Factory 156 Cores (12 cores per node / 2.53 Ghz) 4 GB of Memory Per Core Stated Performance on Website

 Mapping, whole human genome, 15x coverage: 32 Full Human Genomes Per Week (2 x 100 basepair Illumina GA – data  Whole human transcirptome analysis (RNA-seq): 600 Samples per week (130 million 50bp SOLiD reads