Transcript RIMPH-PannonPharma

Research Institute for
Medicinal Plants and Herbs
FAO Expert Roundtable BUDAPEST / Budakalasz 2012.04.2-5
Jozsef Peter PALLOS CEO
RIMPH - PannonPharma
RIMPH-PannonPharma
 RIMPH member of the group of pharma companies:
 PannonPharma Pharmaceuticals Ltd
R+D, mid scale Manufacturing of solid dosage drugs
 Trigon Biotech Ltd  Clongen – Biopharma - Ltd
 RIMPH - GYNKI vertically integrated company for
medicinal plants to herbal medicines
>100 years of tradition
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1884 Páter Béla the founder of medicinal plant research Kolozsvar
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1915 Irk Károly established the HR Establishment for Medicinal Plants
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1924 Kabay János started the poppy opiates extraction R+D
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1925 Augustin Béla developped the medicinal plant improvement, and qualification
system, as the model of the european medicinal plant regulations1951
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1934 Békésy Miklós started thef claviceps purpurea R+D activities
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1951 Institute for mMedicinal Plants - GyógynövényKutató Intézet
1957-től Tétényi Péter started new varieties, improvents > 50 officially tested end
approved varieties
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1969 Budakalasz site opening
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1970 official medicinal plant state control activities, release of batches (plants, drugs,
extracts etc) for medicinal use
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1982 joint venture company of Hungarian (big )pharmaceutical companies
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2003 Nature Conservation Area of Chemotaxonomy Botanical Garden
Janos Kabay
(1896–1936)
Invented the opium free world
Developped the
Extraction process of alkaloids from poppy
straw
- first patent y1925
extraction from green plant
- final patent y1931
extraction from dried poppy capsule
- first pre INCB audit ever y1935
League of Nations -UN predecessor
World class researchers of RIMPH
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Augustin Béla
Száhlender Károly
Kabay János
Kelp Ilona
Békésy Miklós
Kuntz János
Boros Ádám
Szathmáry Géza
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Máthé Imre
Nyiredy Szabolcs
Dános Béla
Bernáth Jenő
Kiniczky Márta
Tyihák Ernő
Szatmáry Miklós
Máthé Imre jnr
Máthé Ákos
First ever medicinal plant state control
system
(1920-1990s)
- y1922 Publishing of Guidelines for wild crfting, collection of medicinal
plants
„Útmutatás a vadontermő gyógynövények gyűjtésére”
(Augustin-Darvas, Gyógy- és Ipari Növényforgalmi Iroda Kiadó Budapest, 1922, 199 pps.)
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y1922 Publishing of Guidelines for cultivation of plant for medicinal
and chemical use
„Gyógy- és vegyipari növények termesztése” (Augustin-Darvas-Schneider,
FM kiadás, Pátria Nyomda, Vác, 1922, 176 pps.)
- y1923 control and use of state seal in export release
- y1934 extension of control to field activities (cultivation, crafting,
processing on site)
This system was kept in force until years of 90s
No control exists in recent years.
RIMPH - GYNKI today as is
RIMPH - GYNKI the vertically integrated company from
medicinal plants research to finished products as herbal
medicines
involving:
research, development,
genebanking,
varieties improvements,
identification and QC analysis laboratories,
extraction of APIs,
manufacturing of finished pharmaceuticals,
registration of own new products
Mission
 Research on plants for medicinal use
 New added value products
 New varieties
 New technologies in agriculture of MAPs
 New API extraction technologies
 11 new medicinal products 4 new varieties in pipeline
Herbal succes elements
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New varieties (efficient, safe)
Motivated farmers
Skilled integrators
High tech processors
Market driven companies
Responsible authorities
Reasonable regulation
Supportive state admin
There are markets for
sure
- The y2050 vision
- More people (?10 Bn)
- 10-15% / year market growth
- example the poppy
Example -poppy alkaloids
the growth is evident
Poppy the wonder chemical plant
Opium centuries are down
Morfin, Tebain are up
Morfin growth
Tebain growth
Aussi success story
Hungary lost markets